A5067632414- Osteoarthritis Treatment and Mechanisms
- Genetic Associations and Epidemiology
- Advancements in Battery Materials
- Geology and Paleoclimatology Research
- Advanced materials and composites
- Advanced Battery Materials and Technologies
- Advanced Battery Technologies Research
- Lipid metabolism and disorders
- High voltage insulation and dielectric phenomena
- Advanced ceramic materials synthesis
- Venous Thromboembolism Diagnosis and Management
- Rheumatoid Arthritis Research and Therapies
- Cancer-related molecular mechanisms research
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Bone and Joint Diseases
- Bone Metabolism and Diseases
- Knee injuries and reconstruction techniques
- Mesenchymal stem cell research
- Bone health and treatments
- Gut microbiota and health
- Evolution and Paleontology Studies
- Magnetism in coordination complexes
- Inflammatory mediators and NSAID effects
- Power Transformer Diagnostics and Insulation
Hainan Medical University
2025
East China Normal University
2025
Xi'an Honghui Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2024
Xi'an Jiaotong University
2013-2024
Chinese Academy of Sciences
2007-2024
Southwest Petroleum University
2013-2024
Yueyang Hospital
2024
Shanghai University of Traditional Chinese Medicine
2024
Dalian Institute of Chemical Physics
2024
Abstract Background The incidence of pulmonary embolism complications in the literature ranges from 10 to 50%, with a 0.5–10% risk fatal embolism. However, biological cause is unknown. Methods This study used data Genome-Wide Association Study (GWAS) Pulmonary Embolism and Human Blood Metabolites UK Biobank, subjects European ancestry were analyzed. We explored relationship between blood metabolites three ways. first analyzed genetic correlation human using linkage disequilibrium score...
Rheumatoid arthritis (RA) is an autoimmune disease that involves T and B cells their reciprocal immune interactions with proinflammatory cytokines. cells, essential part of the system, play important role in RA. helper 1 (Th1) induce interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α), interleukin (IL)-2, which are cytokines, leading to cartilage destruction bone erosion. Th2 primarily secrete IL-4, IL-5, IL-13, exert anti-inflammatory anti-osteoclastogenic effects inflammatory models....
Abstract Lithium–sulfur (Li–S) battery is a promising next‐generation energy storage system. However, the poor cyclability caused by shuttle effect still key challenge for its practical application. Here, polypropylene separator modified with α‐MnO 2 /RuO heterostructure presented to facilitate transformation of lithium polysulfides (LiPSs) and optimize rate‐determining step in both reduction oxidation processes sulfur electrode. The unique effectively suppresses dissolution shuttling...
Abstract Cellular senescence is a steady state of cell cycle arrest necessary to maintain homeostasis in organisms. However, senescent cells may cause neighboring healthy cells, inducing the onset several diseases, such as inflammation, neurological disorders, and atherosclerosis. Therefore, early detection cellular extremely important. β‐Galactosidase (β‐gal), critical marker senescence, can be monitored facilitate diagnosis aging‐related diseases. Furthermore, β‐gal mainly found lysosomes,...
Magnesium (Mg), a nutritional element which is essential for bone development and mineralization, has role in the progression of osteoporosis. Osteoporosis multifactorial disease characterized by significant deterioration microstructure loss. Mg deficiency can affect structure an indirect way through two main regulators calcium homeostasis (parathyroid hormone vitamin D). In human osteoblasts (OBs), parathyroid regulates expression receptor activator nuclear factor-κ B ligand (RANKL)...
Abstract The electrocatalytic preparation of hydrogen at different pH values not only achieves excellent device performance but also promotes the application reactive oxygen species (ROS) clearance and anti‐inflammation. However, it is difficult to develop materials that simultaneously achieve these properties. Herein, beaded necklace‐like Co 9 Se 8 microspheres using a general facile synthetic strategy reported. ‐modified electrode has three applications: efficient water splitting for...
An imbalance between M1 and M2 macrophage polarization is critical in osteoarthritis (OA) development. We investigated the effect of macrophage-derived extracellular vesicles (M2-EVs) to reprogramme macrophages from phenotype for OA treatment. mouse models were treated with M2-EVs. Proteomic analysis was performed evaluate vitro. The as follows: destabilization medial meniscus (DMM) surgery-induced collagenase-induced (CIOA). Hyaluronic acid (HA) used deliver M2-EVs decreased accumulation,...
Senescent cells exert a significant influence over their surrounding cellular environment. chondrocytes (SnChos) were found to be accumulated in degenerated cartilage present joints affected by osteoarthritis. The of SnChos on exogenously transplanted stem has yet reported. In this study, we evaluated the interactions between and bone marrow mesenchymal (BMSCs) when co-cultured as well intra-articular senescent microenvironment (IASM). effect IASM regeneration was also assessed. It that...
Introduction At present, clinical studies have confirmed that osteoporosis (OP) has an inverse relationship with osteoarthritis (OA), but it not been proven from the point of view genetics, so our study hopes to clarify potential effect OP on OA at level gene prediction through two-sample Mendelian randomization (MR) analysis. Methods A MR was adopted research causal (including total OA, knee and hip OA). All data come a public shared database. Such traditional methods as simple weighted...
The aim was to study the genetic correlation and causal relationship between spondyloarthritis (SpA) blood metabolites based on large-scale genome-wide association (GWAS) summary data. GWAS data (3966 SpA 448,298 control cases) of were from UK Biobank, (486 metabolites) human a published study. First, analyzed by linkage disequilibrium score (LDSC) regression. Next, we used Mendelian randomization (MR) analysis perform access metabolites. Random effects inverse variance weighted (IVW) main...
Thick Cenozoic sediments in the southern margin of Junggar Basin accumulated response to uplift and deformation Tianshan Mountains. To better constrain this mountains' tectonic history, we report a detailed magnetostratigraphic study Jingou River section, located northern piedmont Mts. A total 1133 samples were used establish magnetostratigraphy more than 3000 m thick section from exposed base Anjihaihe Formation middle Xiyu Formation. Two vertebrate fossil sites good correlation with CK95...
Stem cell dysfunction and failure have been found in joints afflicted by osteoarthritis (OA). However, the exact factors OA microenvironment that impair stem functions role of development not fully clarified. In this study, we evaluated functional status synovial mesenchymal cells (SMSCs) from patients explored influence OA-SMSCs on cartilage degradation a rat model. We then screened 138 Wnt signaling-related genes synovium patients, focusing effects five WNT ligands SMSC functions. The...
Abstract A new concentrated ternary salt ether‐based electrolyte enables stable cycling of lithium metal battery (LMB) cells with high‐mass‐loading (13.8 mg cm −2 , 2.5 mAh ) NMC622 (LiNi 0.6 Co 0.2 Mn O 2 cathodes and 50 μm Li anodes. Termed “CETHER‐3,” this is based on LiTFSI, LiDFOB, LiBF 4 5 vol% fluorinated ethylene carbonate in 1,2‐dimethoxyethane. Commercial state‐of‐the‐art binary ether electrolytes were also tested as baselines. With CETHER‐3, the electrochemical performance...
There is still some controversy about the relationship between lipids and venous thrombosis (VTE). A bidirectional Mendelian randomization (MR) study was conducted to clarify causal three classical (low-density lipoprotein (LDL), high-density (HDL) triglycerides (TGs)) thromboembolism (VTE) (deep (DVT) pulmonary embolism (PE)). Three VTE were analysed by (MR). We used random effect inverse variance weighted (IVW) model as main analysis median method, simple mode method MR-Egger methods...
Abstract In view of the current debate about relationship between lipids and deep venous thrombosis (DVT) in clinical studies, a two-sample Mendelian randomization (MR) study was conducted to clarify effects five circulating (apolipoprotein A1, apolipoprotein B, low-density lipoprotein, high-density lipoprotein triglycerides) on DVT from perspective genetic inheritance. Five (exposure) were analysed by MR with (outcome) two different data sources. For analysis, we used inverse variance...
Direct intra-articular injection (DIAI) of mesenchymal stem cells (MSCs) is a promising technique for cartilage repair. However, the repair process was hindered by absence scaffold and poor cell-matrix interactions. In this study, we developed pericellular collagen I coating (PCC) on MSCs. The overall performances MSC-PCC homing, chondrogenic differentiation, regeneration have been comprehensively evaluated in New Zealand rabbit model. Firstly, examined morphology physical characteristics...
Kashin-Beck disease (KBD) is an endochondral osteogenesis disorder characterised by epiphysis damage and secondary deformable arthropathy induced multiple external factors, among which selenium (Se) iodine deficiency are important influencing factors. Iodine usually accompanied a low Se content in the soil KBD areas of China. can reverse oxidative to chondrocytes. In addition, related bone conversion rate mineral density. Low will hinder growth change metabolism, resulting decrease Thyroid...
The effects of experimental warming on the growth and physiology grass Elymus nutans forb Potentilla anserina were studied by using open-top chambers (OTCs) in an alpine meadow eastern Tibetan Plateau. treatment increased mean air soil surface temperatures 1.53°C 0.50°C, respectively, but it reduced relative water content layer. Experimental enhanced gas exchange E. nutans, while those P. anserina. resulted efficiency photosystem II (PSII) decreasing anserina; significantly stimulated...