A5023004270- Glioma Diagnosis and Treatment
- Plant tissue culture and regeneration
- Meningioma and schwannoma management
- Plant Reproductive Biology
- Vascular Malformations Diagnosis and Treatment
- Environmental and Agricultural Sciences
- Biochemical and Structural Characterization
- Plant Molecular Biology Research
- Spinal Dysraphism and Malformations
- Spine and Intervertebral Disc Pathology
- Plant Gene Expression Analysis
- Anesthesia and Pain Management
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Plant Disease Management Techniques
- Spinal Fractures and Fixation Techniques
- Cancer, Hypoxia, and Metabolism
- Seedling growth and survival studies
- Medical Imaging and Analysis
- Plant Diversity and Evolution
- Forest, Soil, and Plant Ecology in China
- Plant and animal studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Management of metastatic bone disease
Beijing Tian Tan Hospital
2013-2025
Capital Medical University
2014-2025
Capital University
2010-2025
National Clinical Research Center for Digestive Diseases
2017-2024
Henan Institute of Science and Technology
2007-2024
Suzhou Research Institute
2018-2024
Shanghai Jiao Tong University
2024
Institute of Computing Technology
2022-2024
University of Chinese Academy of Sciences
2022-2024
North China Electric Power University
2024
Abstract Due to the rare incidence of spinal cord astrocytomas, their molecular features remain unclear. Here, we characterized landscapes mutations in H3 K27M, isocitrate dehydrogenase 1 ( IDH1 ) R132H, BRAF V600E, and TERT promoter 83 diffuse astrocytic tumors. Among these samples, thirty-five patients had K27M mutation; this mutant could be observed histological grade II (40%), III IV (20%) astrocytomas. were absent 58 cases tested. The V600E mutation (7/57) was only H3-wildtype...
Abstract Pre-surgery differential diagnosis is valuable for personalized treatment planning in intramedullary spinal cord tumors. This study assessed the performance of sequencing cell-free DNA (cfDNA) cerebrospinal fluid (CSF) these Prospectively enrolling 45 patients with lesions, including diffuse midline glioma (DMG), H3K27-altered (14/45), glioblastoma (1/45), H3-wildtype-astrocytoma (10/45), ependymoma (11/45), and other lesions (9/45), CSF samples were collected via lumbar puncture...
Abstract Background Tyrosine kinase inhibitors (TKIs) are crucial in the targeted treatment of advanced colorectal cancer (CRC). Anlotinib, a multi-target TKI, has previously been demonstrated to offer therapeutic benefits previous studies. Circular RNAs (circRNAs) have implicated CRC progression and their unique structural stability serves as promising biomarkers. The detailed molecular mechanisms specific biomarkers related circRNAs era therapies, however, remain obscure. Methods whole...
Abstract Drug resistance strikingly limits the therapeutic effect of temozolomide (TMZ) (a common drug for glioma). Long non-coding RNA (lncRNA) RMRP has been found to be implicated in glioma progression. However, on TMZ along with related molecular mechanisms is poorly defined glioma. In present study, RMRP, ZNRF3, and IGF2BP3 were screened out by bioinformatics analysis. The expression levels lncRNAs mRNAs measured RT-qPCR assay. Protein genes detected western blot immunofluorescence...
Spinal ependymomas are the most common spinal cord tumors in adults, but their intratumoral cellular heterogeneity has been less studied, and how microglia involved tumor progression is still unknown. Here, our single-cell RNA-sequencing analyses of three ependymoma subtypes dissect microenvironmental landscape reveal tumor-associated macrophage (TAM) subsets with distinct functional phenotypes. CCL2
BackgroundAnaplastic astrocytoma (AA), anaplastic oligoastrocytoma (AOA), and oligodendroglioma (AO) are the major histological subtypes of World Health Organization grade III gliomas. More evidence suggests that AOA is unlikely to be a distinct entity, re-evaluation this issue has been recommended. In study, we divided into 2 subgroups, according molecular biomarkers, compared survivals between them.
Pediatric pineal region tumors are very difficult to cure surgically. The authors used the transcallosal interforniceal approach in patients with these lesions.One hundred fifty children, 98 boys and 52 girls, underwent tumor resection via pediatric neurosurgery ward of TianTan Hospital. ranged age from 1 15 years. Fifty-eight had mature teratomas; 57, immature 14, astrocytomas; 3, glioblastomas; 4, pineoblastomas; 2, pineocytomas; choriocarcinomas; cavernous hemangiomas; germ cell tumors;...
Various sensors have been used to obtain the canopy spectral reflectance for monitoring above-ground plant nitrogen (N) uptake in winter wheat. Comparison and intercalibration of vegetation indices derived from different are important multi-sensor data fusion utilization. In this study, its three ground-based (ASD Field Spec Pro spectrometer, CropScan MSR 16 GreenSeeker RT 100) six wheat field experiments were compared. Then, best sensor (ASD) normalized difference index (NDVI (807, 736))...
Accurate differentiation of intramedullary spinal cord tumors and inflammatory demyelinating lesions their subtypes are warranted because overlapping characteristics at MRI but with different treatments prognosis. The authors aimed to develop a pipeline for lesion segmentation classification using two-dimensional MultiResUNet DenseNet121 networks based on T2-weighted images. A retrospective cohort 490 patients (118 astrocytoma, 130 ependymoma, 101 multiple sclerosis [MS], 141 neuromyelitis...
OBJECTIVE Foramen magnum decompression with duraplasty (FMDD) is one of the most frequently utilized surgical treatments for Chiari malformation type I (CMI) in adults. However, its long-term outcomes remain controversial. The object this study was to evaluate FMDD adults CMI. METHODS In total, 297 CMI who had undergone at authors’ institution between 2011 and 2020 were included retrospective study. Long-term (> 1 year) evaluated using Chicago Outcome Scale (CCOS), visual analog scale...
<title>Abstract</title> Spinal ependymal tumors are a diverse group of neoplasms encompassing three subtypes: spinal ependymoma (SP-EPN), myxopapillary (SP-MPE), and subependymoma (SP-SE). However, the molecular differences among these subtypes remain largely unknown. Here, we identified distinct characteristics each subtype through multi-omics analysis. In grade-2 SP-EPN, abnormal enrichment ciliary signaling, particularly involving MKS complex Hedgehog (Hh) pathway, was evident, suggesting...
H3 K27–altered spinal cord diffuse midline glioma (H3-SCDMG) poses therapeutic challenges. Analysis of 73 clinical samples revealed heightened proliferation in H3-SCDMG versus wild-type tumors, suggesting vulnerabilities. Drug screening identified cytarabine (Ara-C) as highly effective inhibiting K27M cell models, recently established patient-derived cells, and xenograft models. Mechanistically, Ara-C can suppress tumor growth through DNA damage, cell-cycle arrest, apoptosis. An...
Abstract Background Due to their rarity, the clinicopathological characteristics and prognostic factors of spinal cord gliomas are still unclear. Here, we aimed clarify these issues in a cohort 108 astrocytomas. Methods We characterized characteristics, including 2016 World Health Organization (WHO) grade, age, sex, location, segment length, resection, pre‐ postsurgery, Modified McCormick Scale (MMS), radio‐ chemotherapy, Ki‐67 H3 K27M mutations, astrocytomas through heatmaps. The Cox...
Abstract BACKGROUND “Diffuse midline glioma, H3 K27M-mutant” (DMG) mainly arises within the pontine, thalamic, and spinal cord regions. Because of rarity gliomas, general knowledge surrounding DMGs is based on pontine thalamic whereas tumor location tends to influence clinicopathological features prognosis. OBJECTIVE To determine characteristics molecular profiles located in cord. METHODS The clinical pathologic prognosis were comprehensively analyzed a series 44 patients with DMGs. RESULTS...
Leaf equivalent water thickness (LEWT) is an important indicator of crop status. Effectively monitoring the status wheat under different nitrogen treatments for effective management in precision agriculture. Trends variation LEWT plants during plant growth were analyzed based on field experiments which various and two consecutive growing seasons. Two-band spectral indices [normalized difference (NDSI), ratio (RSI), (DSI)], then three-band established best two-band index within range 350–2500...
Metabolomics is an effective tool to test the response of plants environmental stress; however, relationships between metabolites and biological endpoints remained obscure in drought stress. Carex breviculmis widely used forage production, turf management, landscape application it particularly resistant We investigated metabolomic responses C. stress by imposing a 22-day natural soil water loss. The results showed that water-deficit restrained plant growth, reducing height, leaf fresh...
Glioma is the most common malignant brain tumors with poor prognosis. The molecular events involved in development and progression of glioma remain unclear. In this study, expression levels miR-302c-3p were examined tissues by qRT-PCR. vitro vivo functional effects further. Luciferase reporter assays conducted to confirm targeting associations. Results showed that level was significantly lower than those normal (P < 0.001). decreased mi-302c-3p positively associated WHO grade Up-regulation...
Shear-coupled grain boundary motion (SCGBM) is an important and efficacious plasticity mechanism in the deformation of metals. In this work, a molecular dynamic (MD) simulation interaction between SCGBM Σ9[110](221) GB Cu-rich precipitates α-iron was carried out. The effects size, temperature, composition Cu were also studied. It found that inhibited significantly, configuration transformation from spheroid to ellipsoid investigated results. critical stress increased with size precipitates....