A5100408196- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Ferroptosis and cancer prognosis
- Aquatic Invertebrate Ecology and Behavior
- Chromatin Remodeling and Cancer
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Diatoms and Algae Research
- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Photoreceptor and optogenetics research
- Genomics and Chromatin Dynamics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nicotinic Acetylcholine Receptors Study
- Bone Tumor Diagnosis and Treatments
- Brain Metastases and Treatment
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Phytochemistry and Bioactivity Studies
- Menopause: Health Impacts and Treatments
- Antimicrobial agents and applications
- Neurogenetic and Muscular Disorders Research
- Tracheal and airway disorders
Beijing Tian Tan Hospital
2016-2025
Capital Medical University
2016-2025
Hainan Medical University
2021-2025
Hainan General Hospital
2018-2025
Peking University
2024
Wuhan University
2022-2023
Zhongnan Hospital of Wuhan University
2022-2023
First Affiliated Hospital of Xinjiang Medical University
2022
Xinjiang Medical University
2022
Cipher Gene (China)
2022
Recent transcriptomic approaches have demonstrated that there are at least 4 distinct subgroups in medulloblastoma (MB); however, survival studies of molecular adult MB been inconclusive because small sample sizes. The aim this study is to investigate the and identify their clinical prognostic implications a large, single-institution cohort. We determined gene expression profiles for 13 primary MBs. Bioinformatics tools were used establish based on most informative genes dataset....
Programmed cell death‑1 (PD‑1) is an oncogene associated with suppressing proliferation and cytokine production of T cells in the progression liver cancer. microRNAs (miRs) regulate gene expression via specific binding to target 3'untranslated region mRNA. In present study, miR‑374b was indicated interact PD‑1 affect tumor‑targeting capacity cytokine‑induced killer (CIK) cells. inhibitor significantly increased CIK A synthetic small interfering (si)RNA targeting employed silence level Then,...
Terahertz (THz) radiation is a valuable imaging and sensing tool which widely used in industry medicine. However, it biological effects including genotoxicity cytotoxicity are lacking of research, particularly on the nervous system. In this study, we investigated how terahertz with 10mW (0.12 THz) 50 mW (0.157 would affect morphology, cell growth function rat hippocampal neurons vitro.
Glioblastoma (GBM) is one of the most frequent primary intracranial malignancies, with limited treatment options and poor overall survival rates. Alternated glucose metabolism a key metabolic feature tumour cells, including GBM cells. However, due to high cellular heterogeneity, accurately predicting prognosis patients using single biomarker difficult. Therefore, identifying novel metabolism-related signature important may contribute accurate prediction for patients.In this research, we...
Abstract BACKGROUND “Diffuse midline glioma, H3 K27M-mutant” (DMG) mainly arises within the pontine, thalamic, and spinal cord regions. Because of rarity gliomas, general knowledge surrounding DMGs is based on pontine thalamic whereas tumor location tends to influence clinicopathological features prognosis. OBJECTIVE To determine characteristics molecular profiles located in cord. METHODS The clinical pathologic prognosis were comprehensively analyzed a series 44 patients with DMGs. RESULTS...
is a ubiquitous pathogen that causes various infectious diseases through the regulation of quorum sensing (QS). The strategy interfering with QS systems
Machine learning can be applied to identify key genes associated with osteoarthritis (OA). This study aimed explore the differential expression of necroptosis-related (NRGs) during progression OA, gene modules strongly linked onset and assess role CASP1 its correlation immune cell infiltration in OA. Gene profile data were obtained for OA normal tissues: GSE55235 (10 10 synovial tissues) GSE46750 (12 12 tissues). Differential analysis identified 44 NRGs. Weighted co-expression network...
Adult intracranial ependymomas (EPNs) are extremely rare brain tumors. Currently, clinical and molecular factors that could inform individualized treatment strategies still lacking for EPNs in this age group. The aim of study was to investigate potential prognostic indicators rational therapeutic management a large cohort adult EPNs. patients who underwent resection World Health Organization (WHO) grade II or III were included. demographic features, clinicopathologic manifestations,...
Naringenin is a flavonoid extracted from the seed coat of Anacardiaceae plants. Increasing evidence indicates that it has several properties biological significance, such as anti-infection, sterilization, anti-allergy, antioxidant free radical, and anti-tumor. However, its effect on osteoarthritis not been elucidated properly. In this study, treatment primary chondrocytes with interleukin (IL)-1β was found to increase secretions IL-6, tumor necrosis factor (TNF)-α, cyclooxygenase-2 (COX-2)....
The purpose of this study is to explore the potential biological role and prognostic significance chromatin regulators (CRs) in low-grade gliomas (LGGs).CRs were obtained from FACER database. Transcription profiles LGG patients collected TCGA CGGA databases. Differentially expressed CRs (DECRs) between LGGs normal controls identified using DESeq2. consensus clustering algorithm was employed distinguish subtypes based on prognosis-related DECRs. differences clinical molecular characteristics...
Abstract Background Ghost cell odontogenic carcinoma (GCOC) is a rare malignancy characterized by the presence of ghost cells, preferably in maxilla. Only slightly more than 50 case reports GCOC have been documented to date. Due rarity this tumor and its nonspecific clinical criteria, there heightened risk misdiagnosis examination, imaging findings, pathology interpretation. Case presentation A 50-year-old male patient presented hospital due experiencing pain his lower front teeth while...
Objective: Intracranial pineoblastomas are rare neoplasms with poor prognosis. The aim of this study was to describe the independent prognostic factors and treatment strategies for overall survival in pediatric adult patients. Methods: Sixty-four patients were surgically treated between January 2012 December 2018. Results: series included 37 (57.8%) males 27 (42.2%) females. Gross total resection achieved 41 (64.1%) cases, 1-, 3-, 5-year rates 86.3, 52.3, 36.6%, respectively. In group...
Objectives: This study aimed to identify specific diagnostic as well predictive targets of primary myelofibrosis (PMF). Methods: The gene expression profiles GSE26049 were obtained from Gene Expression Omnibus (GEO) dataset, WGCNA was constructed the most related module PMF. Subsequently, Ontology (GO), Kyoto Encyclopedia Genes and Genomes (KEGG), Set Enrichment Analysis (GSEA) Protein-Protein interaction (PPI) network conducted fully understand detailed information interested green module....
Abstract Medulloblastoma (MB) is the most common malignant pediatric brain tumor arising in cerebellum or 4 th ventricle. Cerebellopontine angle (CPA) MBs are extremely rare tumors, with few cases previously described. In this study, we sought to describe clinical characteristics, molecular features and outcomes of CPA MB. We retrospectively reviewed a total 968 patients who had histopathological diagnosis MB at Beijing Neurosurgical Institute between 2002 2016. The demographic...
Abstract Chuviruses belong to the genus Mivirus in newly classified family Chuviridae , and their medical significance remains undetermined 1,2 . Here, we identified a novel chuvirus, Nuomin virus (NOMV), from febrile patients China. NOMV had circular genome presented enveloped spherical particles with diameter of approximately 120–150 nm. Phylogenetically, formed separate clade family, 17.1–83.4% sequence identity other chuviruses. infection was confirmed 54 who tick-bitten history during...
Posterior fossa ependymomas (PFEs) are rare brain tumors classified as PF-EPN-A (PFA) and PF-EPN-B (PFB) subgroups. The study aimed to evaluate the prognosis survival outcomes in PFEs, with a focus on impact of molecular
Alzheimer's disease (AD) is a neurodegenerative disorder with distinct sex bias. Age-related vascular alterations, hallmark of AD onset and progression, are consistently associated sexual dimorphism. Here, we conducted an integrative meta-analysis 335,803 single-nucleus transcriptomes 667 bulk from the system in normal aging to address underlying sex-dependent AD. All cell types male patients exhibited activated hypoxia response downstream signaling pathways including angiogenesis. The...
Glioma is the most common primary tumor of central nervous system (CNS). Centromere protein A (CENPA) plays an essential role in ensuring that mitosis proceeds normally. The effect CENPA on glioma rarely reported. However, current study aims to explore whether aberrant expression promotes progression and potential mechanisms involved.The GEPIA website, Cancer Genome Atlas, Gene Expression Omnibus (GEO) were used assess glioma. results validated by real-time quantitative polymerase chain...