A5101452218- Moyamoya disease diagnosis and treatment
- Neurological Complications and Syndromes
- Intracranial Aneurysms: Treatment and Complications
- Monoclonal and Polyclonal Antibodies Research
- HIV Research and Treatment
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- MRI in cancer diagnosis
- HIV, Drug Use, Sexual Risk
- Glycosylation and Glycoproteins Research
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Plant Molecular Biology Research
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- HIV/AIDS Research and Interventions
- Plant Gene Expression Analysis
- MicroRNA in disease regulation
- Radiopharmaceutical Chemistry and Applications
- HIV/AIDS drug development and treatment
Chinese PLA General Hospital
2023-2025
PLA Academy of Military Science
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Inner Mongolia Medical University
2013-2024
Huazhong University of Science and Technology
2020-2024
Second Hospital of Anhui Medical University
2022-2024
Anhui Medical University
2022-2024
Union Hospital
2021-2024
Institute of Agro-Products Processing Science and Technology
2024
Chinese Academy of Agricultural Sciences
2024
Background One major impediment to improving the management of breast cancer is current lack tumor marker with sufficient sensitivity and specificity. A growing body evidence implicates diagnostic potential circulating miRNAs in detection. MiR-155 plays an important role pathogenesis cancer. However, level miR-155 its clinical relevance are not well established. The objective study was learn more about serum patients Methodology/Principal Findings Using quantitative reverse transcription...
Liquid biopsies, based on cell free DNA (cfDNA) and proteins, have shown the potential to detect early stage cancers of diverse tissue types. However, most these studies were retrospective, using individuals previously diagnosed with cancer as cases healthy controls. Here, we developed a liquid biopsy assay, named hepatocellular carcinoma screen (HCCscreen), identify HCC from surface antigen hepatitis B virus (HBsAg) positive asymptomatic in community population. The training cohort...
Abstract Tumor‐associated macrophage (TAM) infiltration facilitates glioma malignancy, but the underlying mechanisms remain unclear. Herein, it is reported that TAMs secrete exosomal LINC01232 to induce tumor immune escape. Mechanistically, found directly bind E2F2 and promote entry into nucleus; two synergistically promots transcription of NBR1. The increase in binding between NBR1 ubiquitinating MHC‐I protein through ubiquitin domain causes an degradation autophagolysosomes a decrease...
Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are implicated in the regulation of tumor cell ferroptosis. However, prognostic value ferroptosis-related lncRNAs has never been comprehensively explored glioma. In this study, transcriptomic data and clinical information glioma patients were downloaded from TCGA, CGGA Rembrandt databases. We identified 24 lncRNAs, 15 which (SNAI3-AS1, GDNF-AS1, WDFY3-AS2, CPB2-AS1, WAC-AS1, SLC25A21-AS1, ARHGEF26-AS1, LINC00641, LINC00844,...
Abstract Background Currently, there is no clinically relevant non-invasive biomarker for early detection of esophageal squamous cell carcinoma (ESCC). Herein, we established and evaluated a circulating microRNA (miRNA)-based signature the ESCC using systematic genome-wide miRNA expression profiling analysis. Methods We performed candidate discovery three tissue datasets ( n = 108, 238, 216) miRNAs were confirmed in specimens 64) by qRT-PCR. Using serum training cohort 408), conducted...
Abstract Currently, imaging, fecal immunochemical tests (FITs) and serum carcinoembryonic antigen (CEA) are not adequate for the early detection evaluation of metastasis recurrence in colorectal cancer (CRC). To comprehensively identify validate more accurate noninvasive biomarkers urine, we implement a staged discovery-verification-validation pipeline 657 urine 993 tissue samples from healthy controls CRC patients with distinct metastatic risk. The generated diagnostic signature combined...
Abstract Objective Sepsis-induced coagulopathy (SIC) is extremely common in individuals with sepsis, significantly associated poor outcomes. This study attempted to develop an interpretable and generalizable machine learning (ML) model for early predicting the risk of 28-day death patients SIC. Methods In this retrospective cohort study, we extracted SIC from Medical Information Mart Intensive Care III (MIMIC-III), MIMIC-IV, eICU-CRD database according Toshiaki Iba's scale. And overlapping...
Objective: By binding to its high-affinity receptor FcεR1, IgE activates mast cells, macrophages, and other inflammatory vascular cells. Recent studies support an essential role of in cardiometabolic diseases. Plasma level is independent predictor human coronary heart disease. Yet, a direct mechanisms diseases remain incompletely understood. Approach Results: Using atherosclerosis prone Apoe −/− mice IgE-deficient Ige mice, we demonstrated that deficiency reduced lesion burden, lipid...
Objective: The aim of the present study was to evaluate therapeutic effectiveness and safety clonidine adhesive patch in treating tic disorders. Method: A total 437 patients, who met Chinese Classification Mental Disorders–third edition diagnostic criteria for transient disorder (5%), chronic motor or vocal (40%) Tourette (55%), aged 6–18years, were divided randomly into an active treatment group a clinical control group. Participants treated with participants placebo 4weeks. dosage 1.0mg,...
Tourette syndrome (TS) is a common tic disorder in children and adolescents. There preliminary evidence that herbal medicine may possess the potential to treat tics. The purpose of this study was formally evaluate efficacy safety 5-Ling Granule (5-LGr), proprietary polyherbal product, for treatment patients with TS comparison tiapride placebo. In multisite, double-blind, double-dummy, randomized, placebo-controlled trial, 603 aged 5-18 years were randomly assigned placebo (n = 117), 123,...
Rationale: Chemokines contribute to cancer metastasis and have long been regarded as attractive therapeutic targets for cancer. However, controversy exists about whether neutralizing chemokines by antibodies promotes or inhibits tumor metastasis, suggesting that the approach directly target needs be scrutinized. Methods: Transwell assay, mouse experiments survival analysis were performed determine functional role of S100A14 in breast RNA-Seq, secreted proteomics, ChIP, Western blot, ELISA,...
Abstract Aims Blood eosinophil count and cationic protein (ECP) concentration are risk factors of cardiovascular diseases. This study tested whether how eosinophils ECP contribute to vascular calcification atherogenesis. Methods results Immunostaining revealed accumulation in human mouse atherosclerotic lesions. Eosinophil deficiency ΔdblGATA mice slowed atherogenesis with increased lesion smooth muscle cell (SMC) content reduced calcification. protection was muted when received donor from...
Abstract Development of abdominal aortic aneurysms (AAA) enhances lesion group‐2 innate lymphoid cell (ILC2) accumulation and blood IL5. ILC2 deficiency in Rora fl/fl Il7r Cre/+ mice or induced depletion Icos fl‐DTR‐fl/+ Cd4 expedites AAA growth, increases inflammation, but leads to systemic IL5 eosinophil (EOS) deficiency. Mechanistic studies show that protect from formation via EOS. wild‐type (WT) mice, not Il5 −/− induces EOS differentiation bone‐marrow cells mice. IL5, IL13, WT Il13...
The main causes of lung cancer are smoking, environmental pollution and genetic susceptibility. It is an indisputable fact that PAHs related to cancer, benzo(a) pyrene a representative PAHs. purpose the current investigation was investigate interaction between AhR HIF-1 signaling pathways in A549 cells, which provide some experimental basis for scientists find drugs block pathway prevent treat cancer.This project adopts CYP1A1 expression CYP1B1 expressed as measure strength index. VEGF CAIX...
Wood formation is a complex process composing many biological events. To access its key developmental stages, we have established regeneration system that can mimic the initiation and differentiation of cambium cells for Chinese white poplar. Anatomical studies showed new xylem re-appeared in sequence within few weeks after being debarked. This provides opportunity to follow stages wood by sampling clonal trees at different times. We used this combination with proteomic approach analyze...
Glioblastoma (GBM) is one of the most frequent primary intracranial malignancies, with limited treatment options and poor overall survival rates. Alternated glucose metabolism a key metabolic feature tumour cells, including GBM cells. However, due to high cellular heterogeneity, accurately predicting prognosis patients using single biomarker difficult. Therefore, identifying novel metabolism-related signature important may contribute accurate prediction for patients.In this research, we...
Abstract White adipose tissue (WAT) plays a role in storing energy, while brown (BAT) is instrumental the re-distribution of stored energy when dietary sources are unavailable. Interleukin-18 (IL18) cytokine playing T-cell polarization, but also for regulating homeostasis via dimeric IL18 receptor (IL18r) and Na-Cl co-transporter (NCC) on adipocytes. Here we show that signaling metabolism regulated at level utilization, with preferential NCC dominantly IL18r WAT. In Il18r −/− Ncc mice,...
As an inflammatory form of programmed cell death, pyroptosis has been well established to be associated with tumorigenesis and tumor immune microenvironment. In this paper, we aimed at the construction a pyroptosis-related gene prognostic index (PRGPI) for predicting prognosis guiding individualized immunotherapy in glioma patients.Pyroptosis-related genes (PRGs) were identified based on detailed review published literatures. The transcriptome data clinical information patients obtained from...
Ferroptosis is an iron-dependent cell death process mainly triggered by reactive oxygen species (ROS) and lipid peroxidation. Thioredoxin domain protein 12 (TXNDC12) promotes the development of some tumors; however, its function in tumor ferroptosis remains unclear. In this study, we found that knockdown TXNDC12 promoted erastin-induced increase ROS, peroxidation, Fe2+ levels, decreased glutathione content. involved regulating SLC7A11. Further studies showed decrease glioma viability....