A5035234482- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Renal and Vascular Pathologies
- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Connective tissue disorders research
- Health and Medical Research Impacts
- Clinical Laboratory Practices and Quality Control
- Hemodynamic Monitoring and Therapy
- Cardiac Imaging and Diagnostics
- Birth, Development, and Health
- Health Sciences Research and Education
- Pregnancy and preeclampsia studies
- Biomedical Text Mining and Ontologies
- Infective Endocarditis Diagnosis and Management
- Cardiac tumors and thrombi
- Meta-analysis and systematic reviews
- Gestational Diabetes Research and Management
- Blood Pressure and Hypertension Studies
- Eosinophilic Disorders and Syndromes
- Protease and Inhibitor Mechanisms
- Vascular Procedures and Complications
- Cardiac Fibrosis and Remodeling
- Aortic Thrombus and Embolism
Odense University Hospital
2017-2025
University of Southern Denmark
2021-2025
Society for Vascular Surgery
2023
University of New Haven
2023
Region of Southern Denmark
2022
Chartered Institute of Management Accountants
2022
Population-based epidemiologic studies of aortic dissections (ADs) are needed. This study aimed to report clinical characteristics, incidences, and mortality rates for adult patients admitted Danish hospitals with type A AD (TAAD) or B (TBAD) from 1996 through 2016.We conducted a nationwide, population-based register study. All cases registered International Classification Diseases, Tenth Revision codes in the National Patient Registry at time admission hospital available medical records...
To inform researchers of central considerations and limitations when applying biochemical laboratory-generated registry data in clinical public health research.
We aimed to investigate potential associations between serum apolipoprotein levels in early pregnancy and the risk of gestational diabetes mellitus (GDM) adverse outcomes. This was an observational study population-based Odense Child Cohort. Pregnant women were followed from inclusion until childbirth. Apolipoprotein levels, including 12 apolipoproteins (ApoA-I, ApoA-II, ApoA-IV, ApoB, ApoC-I, ApoC-II, ApoC-III, ApoD, ApoE, ApoH, ApoJ, ApoM) measured by targeted proteomics using liquid...
Abstract Aims Blood eosinophil count and cationic protein (ECP) concentration are risk factors of cardiovascular diseases. This study tested whether how eosinophils ECP contribute to vascular calcification atherogenesis. Methods results Immunostaining revealed accumulation in human mouse atherosclerotic lesions. Eosinophil deficiency ΔdblGATA mice slowed atherogenesis with increased lesion smooth muscle cell (SMC) content reduced calcification. protection was muted when received donor from...
Peripheral artery disease (PAD) is a common condition caused by atherosclerosis, which leads to reduced blood flow the limbs. PAD associated with major adverse cardiovascular events (MACE) and limb (MALE). Surfactant protein-D (SP-D) defense lectin expressed in lungs vasculature has been previously PAD. We aimed examine prognostic value of plasma SP-D relation MACE, MALE, all-cause mortality 913 men diagnosed through population-based screening. The cohort was divided into low (<420.4 ng/ml)...
BACKGROUND: The somatic JAK2 V617F sequence variation, a key driver of myeloproliferative neoplasms, has been associated with increased risk aortic aneurysms. This study aimed to explore associations between the variant allele frequency (VAF) and ascending, descending, abdominal METHODS: In DANCAVAS I II trials (Danish Cardiovascular Screening), 15 000 individuals underwent cardiovascular assessments including blood samples noncontrast ECG-gated computed tomography scans. this...
Summary Abdominal aortic aneurysm (AAA) is a common disease with significant heritability. In this study, we performed genome-wide association meta-analysis from 14 discovery cohorts and uncovered 144 independent associations, including 97 previously unreported loci. A polygenic risk score derived was able to explain AAA beyond clinical factors. Genes at loci indicate involvement of lipid metabolism, vascular development remodeling, extracellular matrix dysregulation inflammation as key...
This study evaluated the validity of ICD-10 diagnostic codes for aortic dissections (ADs) in Danish National Patient Registry (DNPR) based upon positive predictive values (PPV).Cases registered DNPR with unspecific AD code DI710 (unspecified AD) from 1996 to 2016, and specific DI710A (AD Type A) DI710B B) 2006 were included. Available medical records all cases underwent review. Confirmed served as "gold standard" when reporting PPV. PPV estimates stratified by regional differences, date, age...
Aortic valve calcification (AVC) detected by non-contrast computed tomography (NCCT) associates with morbidity and mortality in patients aortic stenosis. However, the importance of AVC general population is sparsely evaluated. We intend to describe associations between score on NCCT echocardiographic findings as left atrial (LA) dilatation, ventricular (LV) hypertrophy, area (AVA), peak velocity, mean gradient, replacement (AVR) a scores ≥300 AU. Of 10 471 males aged 65-74 years from Danish...
Platelets play an important role in arterial diseases that extends beyond their traditional function hemostasis and thrombosis.[1] The development progression of ascending thoracic aortic dilations (ATADs) abdominal (AADs) have been associated with increased platelet activation response.[1] [2] Consequently, platelets suggested as potential medical targets to slow expansion rates reduce risk ruptures.
Background: Despite lack of evidence, guidelines recommend beta-blockers (BB) as first-choice antihypertensive treatment in patients with aortic dissection (AD) type A and B. In this observational study, we estimated the risk onset AD long-term BB users mortality survivors between treated without BB.
Background: Prospective data on the ascending thoracic aorta are lacking. This study aimed to estimate growth rates and predictors of adverse aortic events (AAE).
Conclusions: Invasive treatment in type B IMH should be recommended when MAD>50mm.However, AD most complications were due to visceral/peripheral ischaemia and MAD>50mm was uncommon without predictive value for acute phase complications.