A5083911289- Aortic aneurysm repair treatments
- Connective tissue disorders research
- Abdominal vascular conditions and treatments
- Aortic Disease and Treatment Approaches
- Air Quality and Health Impacts
- Infectious Aortic and Vascular Conditions
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Studies on Chitinases and Chitosanases
- Wound Healing and Treatments
- Renal and Vascular Pathologies
- Cancer, Lipids, and Metabolism
- Hemostasis and retained surgical items
- Vascular anomalies and interventions
- Adipokines, Inflammation, and Metabolic Diseases
- Surgical Sutures and Adhesives
Palo Alto University
2024
Stanford University
2022-2023
Heinrich Heine University Düsseldorf
2019-2023
Düsseldorf University Hospital
2019-2023
VA Palo Alto Health Care System
2022-2023
Cardiovascular Institute of the South
2022
Stanford Medicine
2022
Abdominal aortic aneurysm (AAA) is a highly lethal disease with progressive dilatation of the abdominal aorta accompanied by degradation and remodelling vessel wall due to chronic inflammation. Platelets play an important role in cardiovascular diseases, but their AAA poorly understood.
Abstract Aims Abdominal aortic aneurysm (AAA) is a common cardiovascular disease with strong correlation to smoking, although underlying mechanisms have been minimally explored. Electronic cigarettes (e-cigs) gained recent broad popularity and can deliver nicotine at comparable levels tobacco cigarettes, but effects on AAA development are unknown. Methods results We evaluated the impact of daily e-cig vaping using two complementary murine models found that exposure enhanced in both genders....
Summary Abdominal aortic aneurysm (AAA) is a common disease with significant heritability. In this study, we performed genome-wide association meta-analysis from 14 discovery cohorts and uncovered 144 independent associations, including 97 previously unreported loci. A polygenic risk score derived was able to explain AAA beyond clinical factors. Genes at loci indicate involvement of lipid metabolism, vascular development remodeling, extracellular matrix dysregulation inflammation as key...
Purpose . To report the effectiveness of left renal artery (LRA) occlusion using Amplatzer Vascular Plug (AVP) II as treatment for a high-flow arteriovenous fistula (RAVF) with multiple vein aneurysms (RVA) to prevent aneurysm rupture and cardiac decompensation. Case Report A 59-year-old female suffering from post-traumatic RAVF presented tachycardia increased output (CO). Doppler ultrasonography computed tomography (CT) scan revealed RVAs unilateral critically reduced kidney function....
Oxidized regenerated cellulose-based (ORC - TABOTAMP), oxidized non-regenerated (ONRC RESORBA CELL), and gelatin-based (GELA GELITA TUFT-IT) hemostats are commonly used in surgery. However, their impact on the wound healing process remains largely unexplored. We here assess time-dependent effects of exposure to these fibroblast-related processes.Hemostats were applied fibroblast cell cultures for 5-10 (short-), 30 60 min (intermediate-) 24 h (long-term). Representative images hemostat...
Background: Smoking and family history are major risk factors for abdominal aortic aneurysm (AAA). is a powerful modulator of DNA methylation, nicotine can cause heritable epigenetic alterations in animals humans. We found that infusion e-cigarette (e-cig) vaping augment murine AAA, parental augments model AAA offspring, altering tissue methylation patterns. Hypothesis: investigated the effects maternal e-cig mice on their offspring’s experimental risk, transgenerational methylation....
Background: Our lab has identified a role for proprotein convertase subtilisin/kexin type9 (Pcsk9) in murine abdominal aortic aneurysm (AAA). Beyond its pathological effects on degradation of LDL-receptors, and enhancement tissue inflammation via the NF-kB pathway, reports suggest that it alters vascular smooth muscle cell (VSMC) senescence metabolism. However, specific cellular mechanisms connecting Pcsk9 to AAA disease (particularly SMC-derived Pcsk9) are still unclear. Hypothesis:...
Significance: Chronic inflammation is a consistent theme in the progression of cardiovascular disease including AAA. contributes to aortic wall weakening AAA by disrupting ECM and promoting stiffness. Various cell types (fibroblast, macrophages, VSMCs, circulating platelets) inflammatory signaling cascades are implicated weakening. Osteopontin (OPN) well-known pro-inflammatory cytokine, which secreted cells has been found upregulated patients. However, its mechanistical pathway disease’...
Objective: Recent genome-wide association studies revealed a potential role of proprotein convertase subtilisin/kexin type9(Pcsk9) in the human abdominal aortic aneurysm(AAA) disease.Altered Pcsk9 gene expression and smaller AAA diameter were observed murine using porcine pancreatic elastase(PPE) model our lab. increases plasma LDL-cholesterol,enhances tissue inflammation induces vascular smooth muscle cell (VSMC) senescence, hallmarks AAA.However, exact cellular mechanisms disease remain...
Objective: Abdominal aortic aneurysm (AAA) is defined as local weakening and dilatation of the abdominal aorta ≥50% has high incidence in elderly. Current therapy limited to surgical repair, only, no pharmacological shown effectiveness against AAA development growth. Untreated rupture highly associated with death, aged patients are at augmented risk for complications. We therefore sought identify novel agents that could be employed medical therapy. Methods: Using whole genome DNA methylation...
Introduction: Abdominal aortic aneurysm (AAA) is a local weakening and dilatation of the abdominal aorta ≥50%, associated with high mortality in event rupture has no current pharmacologic treatment. Proprotein convertase subtilisin/kexin type 9 (Pcsk9), an enzyme mainly known for its production liver, can cause familial hypercholesterolemia due to gain-of-function mutations. When triggered by pro-inflammatory stimuli, Pcsk9 expression vascular smooth muscle cells (VSMC) been found induce...