Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are implicated in the regulation of tumor cell ferroptosis. However, prognostic value ferroptosis-related lncRNAs has never been comprehensively explored glioma. In this study, transcriptomic data and clinical information glioma patients were downloaded from TCGA, CGGA Rembrandt databases. We identified 24 lncRNAs, 15 which (SNAI3-AS1, GDNF-AS1, WDFY3-AS2, CPB2-AS1, WAC-AS1, SLC25A21-AS1, ARHGEF26-AS1, LINC00641, LINC00844,...

Abstract Background Ferroptosis has been linked to tumor progression and resistance antineoplastic therapy. Long noncoding RNA (lncRNA) exerts a regulatory role in various biological processes of cells, while the function molecular mechanism lncRNA ferroptosis are yet be clarified glioma. Methods Both gain-of-function loss-of-function experiments were employed investigate effects SNAI3-AS1 on tumorigenesis susceptibility glioma vitro vivo. Bioinformatics analysis, Bisulfite sequencing PCR,...

5-Methylcytosine (m5C) methylation is a significant post-transcriptional modification that play crucial role in the development and progression of numerous cancers. Whereas functions molecular mechanisms underlying m5C gliomas remain unclear. This study dedicated to explore changes levels clinical significance writer NSUN4 gliomas. We found high were negatively related prognosis patients with glioma. Moreover, gain- loss-of-function experiments revealed enhancing mRNA promote malignant...

Abstract Improving the chemotherapy resistance of temozolomide (TMZ) is great significance in treatment glioblastoma multiforme (GBM). Long non‐coding RNA just proximal to X‐inactive specific transcript (JPX) has been proven be involved cancer progression. However, intrinsic and molecular mechanism by which JPX orchestrates GBM progression TMZ remain poorly understood. Here, was found significantly elevated tissues cell lines, patients with high expressions showed worse prognoses. Functional...

Abstract Objective The purpose of this study was to develop and validate a nomogram combined multiparametric MRI clinical indicators for identifying the WHO grade meningioma. Materials methods Five hundred sixty-eight patients were included in study, who diagnosed pathologically as having meningiomas. Firstly, radiomics features extracted from CE-T1, T2, 1-cm-thick tumor-to-brain interface (BTI) images. Then, difference analysis least absolute shrinkage selection operator orderly used select...

Glioblastoma multiforme (GBM)is a highly aggressive malignancy of the central nervous system characterized by poor survival rates. Ferroptosis, an iron-dependent cell death pathway, is promising therapeutic target for GBM. However, current treatments targeting pathways have not yielded expected results. Long noncoding RNAs (lncRNAs) been implicated in tumour proliferation, however, their role ferroptosis GBM remains underexplored. This study investigated interplay between lncRNA LINC01088...

As an inflammatory form of programmed cell death, pyroptosis has been well established to be associated with tumorigenesis and tumor immune microenvironment. In this paper, we aimed at the construction a pyroptosis-related gene prognostic index (PRGPI) for predicting prognosis guiding individualized immunotherapy in glioma patients.Pyroptosis-related genes (PRGs) were identified based on detailed review published literatures. The transcriptome data clinical information patients obtained from...

Abstract Diffuse invasion is an important factor leading to treatment resistance and a poor prognosis in gliomas. Herein, we found that expression of the tripartite motif containing 56 (TRIM56), RING-finger domain E3 ubiquitin ligase, was markedly higher glioma than normal brain tissue, significantly correlated with malignant phenotypes prognosis. In vitro vivo experimental studies revealed TRIM56 promoted migration cells. Mechanistically, transcriptionally regulated by SP1 K48-K63-linked...

Abstract Background Emerging evidences have indicated that the aberrant liquid–liquid phase separation (LLPS) leads to dysfunction of biomolecular condensates, thereby contributing tumorigenesis and progression. Nevertheless, it remains unclear whether or how LLPS specific molecules affects prognosis tumor immune microenvironment (TIME) patients with lower-grade glioma (LGG). Methods We integrated transcriptome information 3585 LLPS-related genes comprehensively evaluate patterns 423 LGG in...

Background Nicotinamide adenine dinucleotide (NAD+) metabolism is involved in a series of cancer pathogenesis processes, and considered promising therapeutic target for treatment. However, comprehensive analysis NAD+ events on immune regulation survival has not yet been conducted. Here, we constructed prognostic metabolism-related gene signature (NMRGS) associated with checkpoint inhibitor (ICI) efficacy glioma. Methods 40 genes (NMRGs) were obtained from the Reactome database Kyoto...

Increasing evidences have revealed that N6-methyladenosine (m6A) RNA methylation regulators participate in the tumorigenesis and development of multiple tumors. So far, there has been little comprehension about effects m6A on lower-grade gliomas (LGG). Here, we systematically investigated expression profiles prognostic significance 36 LGG patients from TCGA CGGA databases. Most are differentially expressed tissues as compared with normal brain glioblastoma (GBM) tissues. The consensus...

Glioma is the most common malignant brain tumor in adults, with its tumor-promoting immune microenvironment always being intricate to handle with. Amounts of evidence has accumulated suggest that alternative splicing (AS) related microenvironment. However, comprehensive analysis immune-related AS events and their clinical significance are still lacking glioma.AS transcriptome data 653 glioma patients were downloaded online. ssGSEA was performed on divided them into low, medium high cell...

Background: Hepatocellular carcinoma (HCC) is a common type of primary liver cancer and has poor prognosis. In recent times, necroptosis been reported to be involved in the progression multiple cancers. However, role HCC prognosis remains elusive. Methods: The RNA-seq data clinical information patients were downloaded from Cancer Genome Atlas (TCGA) International Consortium (ICGC) databases. Differentially expressed genes (DEGs) prognosis-related explored, nonnegative matrix factorization...

Inflammatory response plays a crucial role in the development and progression of gliomas. Whereas prognostic esteem inflammatory response-related genes has never been comprehensively explored glioma, RNA-seq information clinical data patients with glioma were extracted from TCGA, CGGA, Rembrandt databases. The differentially expressed (DEGs) picked out between tissue non-tumor brain (NBT). Then, least absolute shrinkage selection operator (LASSO) regression analysis was performed to...

Three‐dimensional models, coupling fluid flow and heat transfer, have been adopted to analyze influences of the process parameters on temperature uniformity in an industrial MOCVD reactor. Important factors, such as inlet gas flow, susceptor rotation, heater power, distance between shield ( d 1 ), well 2 investigated carefully. The system heating condition is characterized by denoted standard deviation temperature, thermal efficiency expressed a combination parameter dissipated energy....

The objective of this study is to explore the relationship between cuproptosis-related long noncoding RNAs (lncRNAs) in hepatocellular carcinoma (HCC). RNA-seq data, including lncRNAs and related clinical information HCC patients, were downloaded from Cancer Genome Atlas database. A signature composed 3 was constructed by LASSO analysis, patients classified into high- low-risk groups. Patients high-risk group had a poorer prognosis compared with group. Univariate Cox multivariate regression...

Glioblastoma multiforme (GBM) is the most malignant brain cancer with great heterogeneities in many aspects, such as prognosis, clinicopathological features, immune landscapes, and immunotherapeutic responses. Considering that gene interaction network relatively stable a healthy state but widely perturbed cancers, we sought to explore multidimensional of GBM through evaluating degree perturbations. The perturbations samples (TCGA cohort) normal (GTEx database) were characterized by edge...

A three-dimensional model focusing on fluid flow, heat transfer, species transport and chemical reaction is investigated in a commercial metal-organic vapor deposition (MOCVD) reactor. The key pre-exponential factor improved to yield more reasonable results matching the experiment data. growth rate uniformity are carefully with premixed non-premixed inlets, as well various temperatures, flow rates V:III ratios. susceptor of reactor divided into Zone A, B C according heater alignment. reveal...