A5013123507- IL-33, ST2, and ILC Pathways
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Asthma and respiratory diseases
- T-cell and B-cell Immunology
- Allergic Rhinitis and Sensitization
- Parasites and Host Interactions
- Toxin Mechanisms and Immunotoxins
- Pediatric health and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Research on Leishmaniasis Studies
- Urticaria and Related Conditions
- Autoimmune and Inflammatory Disorders Research
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Galectins and Cancer Biology
- Immune cells in cancer
- Mast cells and histamine
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Disorders and Syndromes
- Immunodeficiency and Autoimmune Disorders
MRC Laboratory of Molecular Biology
2016-2025
Medical Research Council
2015-2025
The Kids Research Institute Australia
2024
Barwon Health
2024
CSL (Australia)
2023
British Geological Survey
2023
Biomedical Research Institute
2022
University of Cambridge
1998-2019
Marymount University
2019
Hoshi University
2015
ST2 is an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2) isoforms. sST2 a mechanically induced cardiomyocyte protein, serum levels predict outcome in patients acute myocardial infarction or chronic heart failure. Recently, IL-33 was identified as functional ligand of ST2L, allowing exploration the role myocardium. We found that biomechanically protein predominantly synthesized by cardiac fibroblasts. markedly antagonized angiotensin II- phenylephrine-induced...
Type 2 innate lymphoid cells (ILC2s, nuocytes, NHC) require RORA and GATA3 for their development. We show that human ILC2s express skin homing receptors infiltrate the after allergen challenge, where they produce type cytokines IL-5 IL-13. Skin-derived IL-33 receptor ST2, which is up-regulated during activation, are enriched in lesional biopsies from atopic patients. Signaling via induces cytokine amphiregulin expression, increases ILC2 migration. Furthermore, we demonstrate E-cadherin...
Naive CD4+ T cell differentiation into distinct subsets of helper (Th) cells is a pivotal process in the initiation adaptive immune response. Allergens predominantly stimulate Th2 cells, causing allergic inflammation. However, why allergens induce not well understood. Here we show that group 2 innate lymphoid (ILC2s) are required to mount robust response protease-allergen papain. Intranasal administration papain stimulated ILC2s and lung inflammation elevated immunoglobulin E titers. This...
Type 2 immunity, which involves coordinated regulation of innate and adaptive immune responses, can protect against helminth parasite infection, but may lead to allergy asthma after inappropriate activation. We demonstrate that il25−/− mice display inefficient Nippostrongylus brasiliensis expulsion delayed cytokine production by T helper cells. further establish a key role for interleukin (IL)-25 in regulating novel population IL-4–, IL-5–, IL-13–producing non–B/non–T (NBNT), c-kit+, FcεR1−...
We have isolated the human cDNA homologue of a mouse helper T-cell-specific sequence, called P600, from an activated T-cell library. The encodes secreted, mainly unglycosylated, protein with relative molecular mass approximately 10,000. show that and proteins cause extensive morphological changes to monocytes associated up-regulation major histocompatibility complex class II antigens low-affinity receptor for immunoglobulin E (Fc epsilon RII or CD23). In addition, they stimulate...
Innate immunity provides the first line of response to invading pathogens and a variety environmental insults. Recent studies identified novel subsets innate lymphoid cells that are capable mediating immune responses in mucosal organs. In this paper, we describe subset is involved type 2 lungs. Airway exposure naive BALB/c or C57BL/6J mice IL-33 results rapid (<12 h) production IL-5 IL-13 marked airway eosinophilia independently adaptive immunity. lungs nonsensitized mice, IL-33-responsive...
We have generated mice with a deficiency in T1/ST2 expression to clarify the roles of T helper cell type 2 (Th2) responses. Using immunological challenges normally characterized by Th2-like response, we compared responses T1/ST2-deficient those wild-type mice. primary pulmonary granuloma model, induced Schistosoma mansoni eggs, demonstrate that formation, eosinophil infiltration, is abrogated Furthermore, clearly absence expression, levels Th2 cytokine production are severely impaired after...
BackgroundActivation of the group 2 innate lymphoid cell (ILC2) population leads to production classical type cytokines, thus promoting immunity. Chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2), a receptor for prostaglandin D2 (PGD2), is by human ILC2s. However, function CRTH2 in these unclear.ObjectivesWe sought determine role PGD2 and ILC2s compare it with that established ILC2 activators IL-25 IL-33.MethodsThe effects PGD2, IL-25, IL-33 migration, cytokine...
Abstract Type 2 cytokines (IL-4, IL-5, and IL-13) play a pivotal role in helminthic infection allergic disorders. CD4+ T cells which produce type can be generated via IL-4-dependent -independent pathways. Although the pathway is well documented, factors that drive IL-4-independent Th2 cell differentiation remain obscure. We report here new cytokine IL-33, presence of Ag, polarizes murine human naive into population mainly IL-5 but not IL-4. This polarization requires IL-1R-related molecule...
IL-33, a cytokine of the IL-1 family, is closely associated with type II T cell responses. Here, we report an unexpected proinflammatory role IL-33 in inflammatory arthritis. was expressed synovial fibroblasts from patients rheumatoid arthritis (RA). Expression markedly elevated vitro by cytokines. Mice lacking ST2, receptor α-chain, developed attenuated collagen-induced (CIA) and reduced ex vivo collagen-specific induction cytokines (IL-17, TNFα, IFNγ), antibody production. Conversely,...