A5055458077- Animal Disease Management and Epidemiology
- Plant Stress Responses and Tolerance
- Plant-Microbe Interactions and Immunity
- Toxic Organic Pollutants Impact
- Metabolomics and Mass Spectrometry Studies
- Ferroptosis and cancer prognosis
- Plant biochemistry and biosynthesis
- Genomics and Phylogenetic Studies
- Viral Infections and Immunology Research
- Glutathione Transferases and Polymorphisms
- GABA and Rice Research
- Carcinogens and Genotoxicity Assessment
- Virus-based gene therapy research
- Plant Reproductive Biology
- Nitrogen and Sulfur Effects on Brassica
- Berry genetics and cultivation research
- Attention Deficit Hyperactivity Disorder
- Peanut Plant Research Studies
- Cancer Immunotherapy and Biomarkers
- Redox biology and oxidative stress
- Sulfur Compounds in Biology
- RNA Interference and Gene Delivery
- Plant Micronutrient Interactions and Effects
- Protease and Inhibitor Mechanisms
- Pesticide Exposure and Toxicity
Lanzhou Jiaotong University
2025
Mianyang Central Hospital
2025
Putian University
2021-2024
Fujian Agriculture and Forestry University
2015-2024
Third Xiangya Hospital
2023
Central South University
2023
Sun Yat-sen University
2018
Shihezi University
2015
Shanghai Children's Hospital
2008-2013
China Academy of Railway Sciences
2011
Objective: The aim of the present study was to evaluate therapeutic effectiveness and safety clonidine adhesive patch in treating tic disorders. Method: A total 437 patients, who met Chinese Classification Mental Disorders–third edition diagnostic criteria for transient disorder (5%), chronic motor or vocal (40%) Tourette (55%), aged 6–18years, were divided randomly into an active treatment group a clinical control group. Participants treated with participants placebo 4weeks. dosage 1.0mg,...
Foot-and-mouth disease virus (FMDV) is an economically devastating viral leading to a substantial loss the swine industry worldwide. A novel alternative strategy develop pigs that are genetically resistant infection. Here, we produce transgenic (TG) constitutively expressed FMDV-specific short interfering RNA (siRNA) derived from small hairpin (shRNA). In vitro challenge of TG fibroblasts showed shRNA suppressed growth. and non-TG were challenged by intramuscular injection with 100 LD50...
Sulfonimidamides, featuring a hexavalent sulfur structure, are class of key compounds with broad application prospects in the fields pharmaceuticals and agrochemicals. However, their applications have been limited due to lack economically effective synthetic methods. Utilizing cost-effective readily accessible sulfonyl chloride as initial reagent, this method involves sequential formation intermediates, including sulfinamide sulfonimidoyl chloride, culminating synthesis sulfonylimidamide...
Metabolism-related lncRNAs may play a significant role in the occurrence and development of breast cancer. This study aims to identify metabolism-related with high predictive value for prognosis construct model that can predict cancer individually. Transcriptome data clinical patients were retrieved from TCGA database, genes sourced GSEA database. obtained through differential expression analysis Pearson correlation analysis. Prognostic-related further screened using Univariate Cox...
Rice blast disease caused by the fungus Magnaporthe grisea (M. grisea) is one of most serious diseases for cultivated rice Oryza sativa (O. sativa). A key factor causing and defense might be protein-protein interactions (PPIs) between fungus. In this research, we have developed a computational pipeline to predict PPIs rice. After cross-prediction interolog-based domain-based method, achieved 532 potential 27 proteins 236 proteins. Accuracy jackknife test, 10-fold cross-validation test...
Calcium is a universal signal in the regulation of wide aspects biology, but few are known about function calcium control early embryo development. Ca(2+) deficiency soil induces abortion peanut, producing empty pods, which general problem; however, underlying mechanism remains unclear. In this study, was characterized to be caused by apoptosis marked with cell wall degradation. Using method SSH cDNA libraries associated library lift (SSHaLL), 62 differentially expressed genes were isolated...
This study aimed to identify author, country, institutional, and journal collaborations their impacts, assess the knowledge base, existing trends, uncover emerging topics related role of Metalloproteinase in osteosarcoma.945 Articles reviews associated with osteosarcoma were obtained from WoSCC analyzed by Citespace Vosviewer.The main aspects research on MMP OS are invasion metastasis. The latest hotspots found be mechanism promoting metastasis, lung antitumor activity. Notably, invasion,...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitously distributed endocrine-disrupting chemical and reproductive toxicant. In order to elucidate low-dose TCDD-mediated effects on or endocrine functions, female Sprague-Dawley rats were orally administered various concentrations (20, 50, 125 ng/kg once weekly) TCDD for 29 wk. A proteomic analysis of the ovaries by two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization (MALDI) tandem mass spectrometry showed...
Avian influenza A (H7N9) virus has caused several epidemics and infection in both human poultry. With mutation, the H7N9 gained its fifth endemic China. Early diagnosis is crucial for control of viral spread poultry prognosis infected patients. In this study, we developed evaluated a lateral flow dipstick recombinase polymerase amplification (LFD-RPA) assay rapid detection hemagglutinin neuraminidase gene H7N9. Our H7-LFD-RPA N9-LFD-RPA were able to detect 32 fg nucleic acid which more...
Some members of the Rosaceae family, particularly pear, contain stone cells in their fruits. Although pear fruits are well studied, relatively little attention has been given to loquat cells. Only a few reports have suggested relationship between cell traits and storage transport tolerance Previously, we generated variety JT8 from interspecific hybrid cultivar Jiefangzhong (JFZ; Eriobotrya japonica Lindl. cv. Jiefangzhong, female parent) wild Taiwanese (TL; E. deflexa Nakai, male parent)....
Summary It is urgent to mine novel blast‐resistant genes in rice and develop new varieties with pyramiding genes. In this study, a gene, OsBRW1 , was screened from set of near‐isogenic lines (NILs) different ability. Under the infection Magnaporthe oryzae ( M. ), resistant NIL Pi‐4b highly induced than that susceptible Pi‐1 their parent line CO39, ability further confirmed by using CRISPR/Cas9 knockout over‐expression methods. The protein encoded typical NBS‐LRR NB‐ARC domain localized both...
Loquat (Eriobotrya japonica Lindl.) is a subtropical evergreen fruit tree that produces fruits with abundant nutrients and medicinal components. Confirming suitable reference genes for set of loquat samples before qRT-PCR experiments essential the accurate quantification gene expression. In this study, eight candidate were selected from our previously published RNA-seq data, primers each designed evaluated. The Cq values calculated by RT-qPCR in 31 different samples, including 12 subgroups...
Rice blast, caused by the fungus, Magnaporthe grisea (M. grisea), lead to decrease of rice yields widely and destructively, threatening global food security. Although many resistant genes had been isolated identified in various varieties, it is still not enough clearly understand mechanism race-specific ability rice, especially on protein level. In this research, proteomic methods were employed analyze differentially expressed proteins (DEPs) susceptible variety CO39 its two near isogenic...
Single nucleotide polymorphisms (SNPs) are widely used in functional genomics and genetics research work. The high-quality sequence of rice genome has provided a genome-wide SNP proteome resource. However, the impact SNPs on protein phosphorylation status is not fully understood. In this paper, we firstly updated resource based new Ver. 7.0, then systematically analyzed potential Non-synonymous (nsSNPs) status. There were 3,897,312 7.0 genome, among which 9.9% was nsSNPs. Whilst, total...
Abstract Temperature has a vital impact on plant growth and development, heat stress severely threatens agricultural productivity food security. High temperatures can cause annual yield reductions disease in loquat [ Eriobotrya japonica (Thunb.) Lindl.]. However, the molecular mechanisms underlying response are not known. In this study, transcriptome of leaves to was sequenced assembled de novo, differentially expressed genes (DEGs) were identified. A total 16,120 11,668 DEGs identified at 1...
To evaluate the temporal and spatial distribution of knowledge network about tumor microenvironment prognoses explore new research hot spots trends. Articles reviews on in Web Science journal from January 1999 to April 2022 were included. We used CiteSpace VOSviewer software analyze composed journals, institutions, countries, authors, keywords. Frontiers Immunology, Cancers, Oncology have published more than 10% articles this field. China United States contributed most articles. Fudan...
Grain size is one of the critical factors determining rice yield. Previous studies have found grain-size-regulating function Gα in rice. However, regulatory mechanism underlying development grain mediated by still unclear. To reveal functional regulation, a mutant (Gα-Cas9) was firstly constructed through CRISPR/Cas9 strategy and then grown greenhouse field. The results showed that seed length, plant height, 1000-grain weight, spike length were significantly decreased Gα-Cas9 compared to...
Abstract The chloroplast genomes of wild loquat can help to determine their place in the history evolution. Here, we sequenced and assembled two novel loquat’s genomes, one is Eriobotrya elliptica , other an unidentified loquat, which named “YN-1”. Their sizes are 159,471 bp 159,399 bp, respectively. We also a cultivated ‘JFZ’, its genome size 159,156 bp. A comparative study was conducted with six distinct species loquats, including five loquats loquat. results showed that both E. “YN-1”...
The chronic effects low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were examined on protein expression profiles in rat testis, sperm, and serum gonadal hormones. A total of 32 male rats randomly divided into three TCDD-exposed groups, administered either 140, 350, or 875 ng TCDD/kg/week for 29 weeks, respectively, one control group receiving only corn oil. proteins from testis separated analyzed by two-dimensional gel electrophoresis mass spectrometry. TCDD induced significant decreases...