A5055222319- Extracellular vesicles in disease
- Wound Healing and Treatments
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Breast Implant and Reconstruction
- Facial Rejuvenation and Surgery Techniques
- Breast Cancer Treatment Studies
- Circular RNAs in diseases
- Dermatologic Treatments and Research
- MicroRNA in disease regulation
- Growth Hormone and Insulin-like Growth Factors
- RNA modifications and cancer
- Reconstructive Facial Surgery Techniques
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Reconstructive Surgery and Microvascular Techniques
- Cancer Immunotherapy and Biomarkers
- Adipose Tissue and Metabolism
- Facial Nerve Paralysis Treatment and Research
- Breast Lesions and Carcinomas
- Nasal Surgery and Airway Studies
- Kruppel-like factors research
Tongji Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
Shandong Eye Hospital
2024-2025
Shandong First Medical University
2024-2025
Zhejiang Chinese Medical University
2024
Inspire Institute
2024
University of Alberta
2023
First Affiliated Hospital of GuangXi Medical University
2021-2022
Guangxi Medical University
2021-2022
Nanjing Medical University
2016-2021
We aimed to establish the prevalence, characteristics, and outcomes of intracranial atherosclerosis (ICAS) in China by a large, prospective, multicenter study. evaluated 2864 consecutive patients who experienced an acute cerebral ischemia<7 days after symptom onset 22 Chinese hospitals. All underwent magnetic resonance angiography, with measurement diameter main arteries. ICAS was defined as ≥50% reduction on angiography. The prevalence 46.6% (1335 patients, including 261 coexisting...
Cancer stem cells (CSCs) are inherently resistant to chemotherapy, and CSCs in chemotherapy-failed recurrent tumors enriched; however, the cellular origin of chemotherapy-induced CSC enrichment remains unclear. Communication with stromal fibroblasts may induce cancer cell dedifferentiation into through secreted factors. We recently demonstrated that fibroblast-derived exosomes promote chemoresistance colorectal (CRC). Here, we report confer CRC via exosome-induced reprogramming...
Skin tissue, composed of epidermis, dermis, and subcutaneous is the largest organ human body.It serves as a protective barrier against pathogens physical trauma plays crucial role in maintaining homeostasis.Skin diseases, such psoriasis, dermatitis, vitiligo, are prevalent can seriously impact quality patient life.Exosomes lipid bilayer vesicles derived from multiple cells with conserved biomarkers important mediators intercellular communication.Exosomes skin cells, blood, stem main types...
Delayed wound healing brings additional physical, mental, and financial burdens. Microneedles (MNs) are a novel dressing form can incorporate drug delivery systems. Quercetin is known for its remarkable antioxidant capacity may have distinctive effect on healing. We designed constructed gelatin methacryloyl (GelMa) MNs carrying (Q-MNs). In vitro, the physical properties, cell safety, migration, angiogenesis, collagen formation, oxidative stress levels, were performed to characterize Q-MNs....
Insulin and insulin-like growth factors (IGFs) mediate a variety of signals involved in mammalian development metabolism. To study the metabolic consequences IGF-I deficiency, we used liver IGF-I–deficient (LID) mouse model. The LID mice show marked reduction (∼75%) circulating elevated hormone (GH) levels. Interestingly, fourfold increase serum insulin levels (2.2 vs. 0.6 ng/ml control mice) abnormal glucose clearance after injection. Fasting blood those tolerance test were similar between...
Keloids are pathological scars characterized by excessive fibroblast proliferation, abnormal collagen deposition, and chronic inflammation, which often result in high recurrence rates limited treatment success. Targeting BACH1 with gene therapy has shown promise regulating activity reducing inflammation. However, effective delivery systems for targeted keloids remain a major challenge. Here, we develop novel nanocarrier platform based on orthogonal upconversion nanoparticles (OUNCs) to...
Abstract Background N6-methyladenosine (m6A), the most abundant and reversible modification of mRNAs in eukaryotes, plays pivotal role breast cancer (BC) tumorigenesis progression. Circular RNAs (circRNAs) can act as tumor promoters or suppressors by microRNA (miRNA) sponges BC. However, underlying mechanism circRNAs BC progression via regulating m6A modulators remains unclear. Methods Prognostic RNA methylation regulators were identified 1065 patients from The Cancer Genome Atlas (TCGA)...
Background Orofacial clefts are the most common congenital malformation, but global burden and trends of orofacial have not been comprehensively analysed. The aim this study was to assess incidence, deaths disability-adjusted life years (DALYs) by countries, regions, sex sociodemographic index (SDI) from 1990 2019.Methods data on were obtained Global Burden Disease Study 2019. DALYs analysed SDI. Age-standardized rates estimated annual percentage change (EAPC) calculated evaluate temporal...
Identification and isolation of breast cancer stem cells (CSCs) based on CD44/CD24 expression and/or enzymatic activity aldehyde dehydrogenase 1 (ALDH1). However, the differences among CD44+/CD24‑/low cells, ALDH1+ overlap between sub‑populations have not been frequently investigated. Thus, it is imperative to improve understanding CSC with different markers. CD44+/CD24‑/low, ALDH1+CD44+/CD24‑/low cell populations were isolated from fresh tissues analyzed by flow cytometry...
The metastasis and poor prognosis are still regarded as the main challenge in clinical treatment of breast cancer (BC). Both N6-methyladenosine (m6A) modification lncRNAs play vital roles carcinogenesis evolvement BC. Considering unknown association m6A BC, this study therefore aims to discern m6A-related explore their prognostic value BC patients. Firstly, a total 6 were screened from TCGA database accordingly constructed prognostic-predicting model. patients then divided into high-risk...