A5020709052- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Parasitic Infections and Diagnostics
- Genomics and Chromatin Dynamics
- Connexins and lens biology
- Rabies epidemiology and control
- Retinal Development and Disorders
- Developmental Biology and Gene Regulation
- Animal Genetics and Reproduction
- Congenital heart defects research
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Fungal and yeast genetics research
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Muscle Physiology and Disorders
- Osteoarthritis Treatment and Mechanisms
- Corneal Surgery and Treatments
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Protein Kinase Regulation and GTPase Signaling
- Renal and related cancers
- Kruppel-like factors research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Melanoma and MAPK Pathways
Xi'an Jiaotong University
2025
Jilin University
2019-2025
China Three Gorges University
2025
Chinese Academy of Agricultural Sciences
2016-2024
Agricultural Genomics Institute at Shenzhen
2024
Shenzhen Third People’s Hospital
2024
Southern University of Science and Technology
2024
Universidade de São Paulo
2013-2024
Qilu Hospital of Shandong University
2024
Huashan Hospital
2024
Cancer stem cells (CSCs) are inherently resistant to chemotherapy, and CSCs in chemotherapy-failed recurrent tumors enriched; however, the cellular origin of chemotherapy-induced CSC enrichment remains unclear. Communication with stromal fibroblasts may induce cancer cell dedifferentiation into through secreted factors. We recently demonstrated that fibroblast-derived exosomes promote chemoresistance colorectal (CRC). Here, we report confer CRC via exosome-induced reprogramming...
Previous studies indicate that activation of c-Jun kinase (JNK) is necessary for apoptosis trophic factor-deprived PC12 cells and death in this system suppressed by multiple agents, including BCL2, inhibitors the interleukin-1-converting enzyme (ICE) family proteases, blockers transcription, a variety small molecules with differing modes action. Here, we determine order which these agents block relative to JNK activation. Overexpression BCL2 promotes cell survival blocks caused factor...
Establishment of anteroposterior (AP) polarity is one the earliest decisions in cardiogenesis and plays an important role coupling between heart blood vessels. Recent research implicated retinoic acid (RA) communication AP to heart. We utilized embryo culture, situ hybridization, morphometry, fate mapping treatment with RA pan-antagonist BMS493 investigate relationship cardiac precursors signalling. describe two phases signalling by RA, reflected RALDH2 expression. The first phase (HH4-7)...
The c-Jun N-terminal kinase signaling cascade appears to play a role in some cases of cell death, including neuronal apoptosis. CEP-1347 (KT7515), an indolocarbazole the K252a family, blocks this stress and promotes survival. Here, we used probe whether death pathways activated by distinct insults also possess elements common. Cultured rat sympathetic neurons neuronally differentiated PC12 cells were induced die withdrawal nerve growth factor, exposure ultraviolet irradiation, or subjection...
Our prior work established that comparable concentrations of N-acetylcysteine (NAC) both block the proliferation PC12 cells and prevent death trophic factor-deprived sympathetic neurons cells. The present addresses several aspects mechanisms these actions. NAC increases intracellular levels glutathione (GSH) by approximately 10-fold in However, blockade this increase treatment with buthionine sulfoximine did not affect either promotion survival or inhibition DNA synthesis. Thus, actions are...
We have shown that N-acetylcysteine (NAC) promotes survival of sympathetic neurons and pheochromocytoma (PC12) cells in the absence trophic factors. This action NAC was not related to its antioxidant properties or ability increase intracellular glutathione levels but instead dependent on ongoing transcription seemed attributable as a reducing agent. Here, we investigate mechanism by which neuronal survival. show activates Ras-extracellular signal-regulated kinase (ERK) pathway PC12 cells....
Inhibitors of interleukin-1β converting enzyme (ICE) and a related group cysteine aspartases the ICE/ced-3 family inhibit cell death in variety settings, including PC12 cells sympathetic neurons following withdrawal trophic support. To assess particular member(s) that are relevant to position their activation within apoptotic pathway, we have used specific substrates measure ICE-like CPP32-like enzymatic activity naive neuronally differentiated had been deprived support (nerve growth factor...
Considering that breast cancer usually begins in the lining of ducts, local drug administration into ducts could target cancers and pre-tumor lesions locally while reducing systemic adverse effects. In this study, a cationic bioadhesive nanoemulsion was developed for intraductal C6 ceramide, sphingolipid mediates apoptotic non-apoptotic cell death. Bioadhesive properties were obtained by surface modification with chitosan. The optimized displayed size 46.3 nm positive charge, not affected...
Abstract Background Clonorchis sinensis is a zoonotic parasite causing clonorchiasis-associated human disease such as biliary calculi, cholecystitis, liver cirrhosis, and it currently classified carcinogenic to humans for cholangiocarcinoma. MicroRNAs (miRNAs) are non-coding, regulating small RNA molecules which essential the complex life cycles of parasites involved in parasitic infections. To identify characterize miRNAs expressed adult C. residing chronically tract, we developed an...
Abstract Aim To identify microRNAs (miRs) involved in the regulation of skeletal muscle mass. For that purpose, we have initially utilized an silico analysis, resulting identification miR‐29c as a positive regulator Methods was electrotransferred to tibialis anterior address its morphometric and functional properties determine level satellite cell proliferation differentiation. qPCR used investigate effect overexpression on trophicity‐related genes. C2C12 cells were impact myogenesis...
Cancer cells have distinct metabolomic profile. Metabolic enzymes regulate key oncogenic signaling pathways and an essential role on tumor progression. Here, serum analysis was performed in 45 patients with T-cell lymphoma (TCL) 50 healthy volunteers. The results showed that dysregulation of choline metabolism occurred TCL related to cell overexpression kinase-α (Chokα). In T-lymphoma cells, pharmacological molecular silencing Chokα significantly decreased Ras-GTP activity, AKT ERK...
Abstract Epithelial invagination in many model systems is driven by apical cell constriction, mediated actin and myosin II contraction regulated GTPase activity. Here we investigate constriction during chick lens placode invagination. Inhibition of polymerization activity cytochalasin D or blebbistatin prevents To further verify if invaginate through analyzed the role Rho‐ROCK pathway. Rho GTPases expression at portion occurs with same dynamics as that cytoskeleton. Overexpression pan‐Rho...
Synanthropic rats and mice share the same environment with humans play an important role in epidemiology of toxoplasmosis; however, there is limited information about prevalence genetic characterization Toxoplasma gondii synanthropic China. In present study, T. naturally infected rodents (Rattus norvegicus Mus musculus) were investigated urban area Xuzhou city, Eastern China between June 2013 August 2014. DNA from brain each animal was prepared screened by specific PCR assay targeting...
We improved the developmental capacity of porcine early embryos via supplementation with fisetin during in vitro culture (IVC). In addition, we investigated antioxidant mechanism activation NRF2-ARE signalling pathway embryos. Fisetin (0, 1, 2.5 and 5 μM) was supplemented IVC to observe its effects on ability parthenogenetic (PA), fertilization (IVF) somatic cell nuclear transfer (SCNT) The capacity, mitochondrial function, proliferation apoptosis levels PA were detected fluorescence...