A5082785833- Coastal and Marine Dynamics
- Ocean Waves and Remote Sensing
- Tropical and Extratropical Cyclones Research
- Quantum optics and atomic interactions
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Traditional Chinese Medicine Analysis
- Medicinal Plant Extracts Effects
- Eicosanoids and Hypertension Pharmacology
- Advanced Battery Technologies Research
- Metabolism, Diabetes, and Cancer
- Biochemical Acid Research Studies
- Atomic and Subatomic Physics Research
- Laser-Matter Interactions and Applications
- Advancements in Solid Oxide Fuel Cells
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Studies
- Proteins in Food Systems
- Advanced Fiber Laser Technologies
- Growth Hormone and Insulin-like Growth Factors
- Medicinal Plants and Bioactive Compounds
- Antioxidant Activity and Oxidative Stress
- Electronic and Structural Properties of Oxides
- Coastal wetland ecosystem dynamics
- Free Radicals and Antioxidants
Shenyang Pharmaceutical University
2014-2025
Xi'an Jiaotong University
2015-2025
South China University of Technology
2019-2024
Wuhan University of Technology
2024
Jinan University
2024
Shandong Jiaotong University
2015-2024
Dalian Maritime University
2014-2023
University of California, Irvine
2010-2023
Chinese Academy of Sciences
2006-2022
Stomatology Hospital
2022
To understand better the cell and molecular basis for epidemiologic association between cigarette smoke, oxidant injury, age-associated macular degeneration, authors examined effects of acrolein, a major toxicant in on oxidative mitochondrial damage retinal pigment epithelial (RPE) cells reduction this by lipoic acid.Cultured human ARPE19 primary cultures fetal (hf)RPE were treated with acrolein. The toxicity acrolein protective R-alpha-lipoic acid variety previously described...
Abstract To find effective agents for Parkinson's disease (PD) prevention and therapy, we examined the protective effects of polyhydroxylated fullerene derivative C 60 (OH) 24 in a 1‐methyl‐4‐phenylpyridinium (MPP + )‐induced acute cellular PD model human neuroblastoma cells free radical scavenging this with an electron spin resonance (ESR) spectrometer. Pretreatment at concentrations greater than 20 μM showed significant on MPP ‐induced loss cell viability, decreases mitochondrial function...
Abstract Background Aberrations in the Wnt pathway have been reported to be involved metastasis of prostate cancer (PCa) bone. We investigated effect and underlying mechanism a naturally-occurring inhibitor, WIF1, on growth cellular invasiveness bone metastatic PCa cell line, PC3. Results The WIF1 gene promoter was hypermethylated its expression down-regulated majority (7 8) lines. Restoration PC-3 cells resulted decreased motility via up-regulation epithelial markers (E-cadherin, Keratin-8...
The incidence of human urinary bladder cancer increases markedly with age, suggesting a mechanistic connection between aging and carcinogenesis potential use anti-aging agents in chemoprevention. Rhodiola rosea, growing high altitude or cold regions the world, has been reported to have effects Drosophila. We demonstrated that R. rosea extract one its bioactive components, salidroside, inhibited growth cell lines minimal effect on nonmalignant epithelial cells TEU-2. Interestingly,...
Abstract Electrolytes with high stability against both Li anode and high‐voltage cathode are critical for high‐energy long‐cycling lithium metal batteries (LMBs). However, the free active solvents in common electrolytes susceptible to decomposition at cathode. Although recently developed locally high‐concentration (LHCEs) have largely restricted via + coordination, molecules still released upon desolvation of surface electrodes, causing continuous during processes. Here, a molecule...
Abstract Local high concentration electrolytes (LHCEs) have been proved to be one of the most promising systems stabilize both voltage cathodes and Li metal anode for next‐generation batteries. However, solvation structures interactions among different species in LHCEs are still convoluted, which bottlenecks further breakthrough on electrolyte development. Here, it is demonstrated that hydrogen bonding interaction between diluent solvent crucial construction corresponding interphase...
Limited success has been achieved in extending the survival of patients with metastatic and hormone-refractory prostate cancer (HRPC). There is a strong need for novel agents treatment prevention HRPC. We have shown that flavokawain B (FKB), kava chalcone, about 4- to 12-fold more effective reducing cell viabilities androgen receptor (AR)-negative, HRPC lines DU145 PC-3 than AR-positive, hormone-sensitive LAPC4 LNCaP, minimal effect on normal prostatic epithelial stromal cells. FKB induces...
Abstract Individualism and collectivism form a paired concept frequently used in studying cross-cultural communication. Yet conflicting findings on have led researchers to question its applicability across cultures, especially concerning the meaning of "collective". By definition, "collective" refers large groups that, through common identity, tie members together into community. The scale measure collectivism, however, has often in-group as examples explore way respondents relate others. As...
In humans, low levels of growth hormone (GH) and its mediator, IGF-1, associate with hepatic lipid accumulation. mice, congenital liver-specific ablation the GH receptor (GHR) results in reductions circulating IGF-1 steatosis, associated systemic insulin resistance. Due to intricate relationship between relative contribution each development steatosis is unclear. Our goal was dissect mechanisms by which resistance leads overall resistance, independent IGF-1. We have generated a combined...
Recently, there has been a growing focus on researching ways to delay aging and protect against age-related illnesses. Small molecular exogenous peptides, sourced from dietary elements like animals, plants, microorganisms, have demonstrated considerable potential in exerting anti-aging effects. Notably, natural food-derived peptides exhibited enhanced stability, safety, absorption efficiency, heightened biological activity. These attributes position them with greater for mitigating...
Epoxyeicosatrienoic acids with anti-inflammatory effects are inactivated by soluble epoxide hydrolase (sEH). Both sEH and histone deacetylase 6 (HDAC6) inhibitors being developed as neuropathic pain relieving agents. Based on the structural similarity, we designed a new group of compounds inhibition both HDAC6 obtained compound
Abstract Hydroxytyrosol (HTS) is a natural polyphenol abundant in olive oil. Increasing evidence indicates HTS has beneficial effect on human health for preventing various diseases. In the present study, we investigated protective effects of acrolein‐induced toxicity retinal pigment epithelial cell line, ARPE‐19, cellular model smoking‐ and age‐related macular degeneration. Acrolein, major component gas phase cigarette smoke also product lipid peroxidation vivo , at 75 μmol/L 24 h caused...
Excessive dietary fat intake causes systemic metabolic toxicity, manifested in weight gain, hyperglycemia, and insulin resistance. In addition, carbohydrate utilization as a fuel is substantially inhibited. Correction or reversal of these effects during high-fat diet (HFD) exceptional interest light widespread occurrence diet-associated disorders global human populations. Here we report that mangiferin (MGF), natural compound (the predominant constituent Mangifera indica extract from the...
Chronic over-nutrition is a major contributor to the spread of obesity and its related metabolic disorders. Development therapeutics has been slow compared speedy increase in occurrence these We have identified natural compound, mangiferin (MGF) (a predominant component plants Anemarrhena asphodeloides Mangifera indica), that can protect against high fat diet (HFD) induced obesity, hyperglycemia, insulin resistance hyperlipidemia mice. However, molecular mechanisms whereby MGF exerts...