A5003904670- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Renal and related cancers
- Genetic Syndromes and Imprinting
- Cancer-related Molecular Pathways
- Ovarian cancer diagnosis and treatment
- Digestive system and related health
- BRCA gene mutations in cancer
- Thyroid Disorders and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Lipid metabolism and disorders
- Childhood Cancer Survivors' Quality of Life
- Pituitary Gland Disorders and Treatments
- Estrogen and related hormone effects
- RNA modifications and cancer
- Cancer Risks and Factors
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Diet and metabolism studies
- Mitochondrial Function and Pathology
Tel Aviv University
2016-2025
Technion – Israel Institute of Technology
2024
Hillel Yaffe Medical Center
2022-2023
Weatherford College
2009-2013
Schneider Children's Medical Center
2013
University of Florida
1988-2004
Florida College
1990-2004
University of Lübeck
2002
National Institute of Diabetes and Digestive and Kidney Diseases
1989-1999
National Institutes of Health
1989-1999
The insulin-like growth factor I receptor (IGF-I-R) plays a critical role in transformation events. It is highly overexpressed most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Tumor suppressor p53 nuclear transcription that blocks cycle progression and induces apoptosis. the frequently mutated gene human cancer. Cotransfection of Saos-2 (os-teosarcoma-derived cells) RD (rhabdomyosarcoma-derived cells with IGF-I-R promoter constructs driving...
To investigate the potential role(s) of insulin-like growth factors (IGFs) in embryogenesis, we have used situ hybridization histochemistry to localize mRNAs for IGF-I, IGF-II, and type I IGF receptor during an early period rat embryonic development (embryonic days 14 15). IGF-I IGF-II were found distinctly different patterns cellular distribution. mRNA was particularly abundant undifferentiated mesenchymal tissue vicinity sprouting nerves spinal ganglia, circumscribed regions developing...
Wilms tumor is a pediatric neoplasm that arises from the metanephric blastema. The expression of gene encoding insulin-like growth factor II (IGF-II) often elevated in these tumors. Since many actions IGF-II are mediated through activation IGF-I receptor (IGF-IR), we have measured levels IGF-IR mRNA normal kidney and samples using solution hybridization/RNase protection assays. tumors were 5.8-fold higher than adjacent tissue. Among themselves, those containing heterologous stromal elements...
We have examined, in liver and extrahepatic tissues, the effects of fasting on total insulin-like growth factor I (IGF-I) mRNA levels, levels different IGF-I mRNAs generated by alternative splicing primary transcript, receptor binding levels. A 48-h fast decreased approximately 80% lung liver, 60% kidney muscle, only 30-40% stomach, brain, testes. In heart, did not change. The variants, however, were essentially coordinately regulated within a given tissue. Specific 125I-IGF-I lung, testes,...
Insulin analogues are widely used in the treatment of diabetes mellitus. Some insulin were reported to display atypical activities vitro that resemble those insulin-like growth factor-I (IGF-I). The aim this study was investigate whether two long-acting [glargine (Lantus, Sanofi Aventis, Germany) and detemir (Levemir, Novo Nordisk, Denmark)] short-acting [lispro (Humalog, Eli Lilly, Indianapolis, USA) aspart (Novolog, exhibit IGF-I-like on cultured cancer cells comparison with IGF-I regular...
Accumulating epidemiological evidence shows that obesity is associated with an increased risk of several types adult cancers, including endometrial cancer. Chronic hyperinsulinemia, a typical hallmark diabetes, one the leading factors responsible for obesity-cancer connection. Numerous cellular and circulating are involved in biochemical chain events from hyperinsulinemia insulin resistance to cancer and, eventually, tumor development. Metformin oral anti-diabetic drug biguanide family used...
The Growth Hormone (GH) Research Society (GRS) convened a workshop to address important issues regarding trial design, efficacy, and safety of long-acting growth hormone preparations (LAGH).A closed meeting 55 international scientists with expertise in GH, including pediatric adult endocrinologists, basic scientists, regulatory participants from the pharmaceutical industry.Current literature was reviewed for gaps knowledge. Expert opinion used suggest studies required potential efficacy...
Introduction Endometrial cancer (EC) is the only gynecologic malignancy showing increasing trends in incidence and mortality. While standard treatment has been effective primarily for early-stage EC, precision medicine with tailored therapy revolutionized management of this disease. Genome sequencing analyses have identified four sub-types EC. Treatments primary metastatic disease can now be more accurately to achieve better oncologic results.
The insulin-like growth factor-I receptor (IGF-I-R) has been implicated in the etiology and/or progression of Wilms' tumor, a pediatric malignancy kidney that is often associated with deletion or mutation WT1 tumor suppressor gene. expression IGF-I-R gene increased as compared normal tissue. Furthermore, levels mRNA individual tumors have shown to be inversely correlated mRNA, suggesting under negative control WT1. activity an promoter/luciferase construct Chinese hamster ovary cells was...
We have demonstrated the expression of rat brain/HepG2 glucose transporter gene in primary cultures neuronal and glial cells by Northern blot analysis with a brain cDNA probe. Incubation both insulin insulin-like growth factor-I induced time- dose-dependent increase steady state levels mRNA. The maximal response was achieved between 2-4 h subsequently decreased. Both at dose 1 ng/ml elicited an approximately 57% mRNA after 90 min, suggesting that each peptide acting through its own receptor....
The insulin-like growth factors, IGF-I and IGF-II are a familyof mitogenic polypeptides with important roles in differentiation. biological actions of the IGFs mediated by receptor (IGF-IR), cell-surface tyrosine kinase, whose activation serum seems to be key step breast cancer initiation. Evidence accumulated indicates that estrogens stimulate expression activity IGF axis components. aim our study was examine transcriptional mechanisms involved regulation IGF-IR gene estrogen (ER). For this...
Insulinlike growth factor I (IGF-I) is a mitogenic hormone with important regulatory roles in and development. One of the target organs for IGF-I action kidney, which synthesizes abundant receptors itself. To study involvement receptor development nephropathy, one major complications diabetes mellitus, we measured expression these genes kidney other tissues streptozocin-induced diabetic rat. The binding 125I-labeled to crude membranes was same tissues. We observed 2.5-fold increase...