A5059883652- Genomics and Phylogenetic Studies
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Chromatin Dynamics
- GABA and Rice Research
- Fiber-reinforced polymer composites
- Advanced materials and composites
- Metabolomics and Mass Spectrometry Studies
- Cancer-related molecular mechanisms research
- Additive Manufacturing and 3D Printing Technologies
- Cancer, Hypoxia, and Metabolism
- Catalytic Cross-Coupling Reactions
- Insect and Pesticide Research
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Insect Pest Control Strategies
- Polyamine Metabolism and Applications
- Molecular Biology Techniques and Applications
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Insect Resistance and Genetics
- Advanced biosensing and bioanalysis techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced ceramic materials synthesis
- Circular RNAs in diseases
- Bacterial Identification and Susceptibility Testing
Jinzhou Medical University
2016-2024
China Three Gorges University
2023-2024
Zhejiang University
2022-2023
Shanghai Jiao Tong University
2023
Jackson Laboratory
2017-2022
South China Botanical Garden
2018-2022
Ministry of Agriculture and Rural Affairs
2022
Chinese Academy of Sciences
2017-2022
Army Medical University
2021
Punan Hospital
2021
Abstract The plant metabolome is characterized by extensive diversity and often regarded as a bridge between genome phenome. Here we report metabolic phenotypic genome-wide studies (mGWAS pGWAS) in rice grain that, addition to previous GWAS leaf maize kernel, show both distinct overlapping aspects of genetic control metabolism within species. We identify new candidate genes potentially influencing important and/or morphological traits. that the differential architecture different tissues...
Significance Although plant metabolites are critical for both and human nutrition, the genetic control of metabolome remains largely unknown. Here, a analysis rice resulted in identification hundreds metabolic quantitative trait loci with high resolution large effects. We observed distinct overlapping accumulation patterns complex regulation metabolism different tissues. Twenty-four candidate genes, mainly those underlying phenolics, were assigned corresponding pathways reconstructed rice....
Rice (Oryza sativa) provides a staple food source for more than 50% of the world's population. An increase in yield can significantly contribute to global security. Hybrid breeding potentially help meet this goal because hybrid rice often shows considerable when compared with pure-bred cultivars. We recently developed marker-guided prediction method and showed substantial through genomic breeding. now have transcriptomic metabolomic data as potential resources prediction. Using six methods,...
Insecticidal protein genes from the bacterium Bacillus thuringiensis (Bt) are expressed by transgenic Bt crops (Bt crops) for effective and environmentally safe pest control. The development of resistance to these insecticidal proteins is considered most serious threat sustainability crops. Resistance in fall armyworm (Spodoptera frugiperda) populations Puerto Rico corn producing Cry1Fa resulted, first time United States, practical resistance, was withdrawn local market. In this study, we...
Phenolamides (PAs) are specialized (secondary) metabolites mainly synthesized by BAHD N-acyltransferases. Here, we report metabolic profiling coupled with association and linkage mapping of 11 PAs in rice (Oryza sativa). We identified 22 loci affecting leaves 16 seeds. eight N-acyltransferases located on five chromosomes diverse specificities, including four aromatic amine show that genetic variation is determined, at least part, allelic the tissue specificity expression genes responsible...
Abstract Replication protein A (RPA), a highly conserved single-stranded DNA-binding in eukaryotes, is stable complex comprising three subunits termed RPA1, RPA2, and RPA3. RPA required for multiple processes DNA metabolism such as replication, repair, homologous recombination yeast (Saccharomyces cerevisiae) human. Most eukaryotic organisms, including fungi, insects, vertebrates, have only single gene that encodes each subunit. Arabidopsis (Arabidopsis thaliana) rice (Oryza sativa),...
Background:The unfolded protein response, autophagy and endoplasmic reticulum (ER) stress-induced apoptosis regulate tumor cell fate have become novel signaling targets for the development of cancer therapeutic drugs.Curcumin has been used to treat several different cancers, including ovarian cancer, in clinical trials research; however, role ER stress effects curcumin new analogues remains unclear.Methods: Cell viability was determined using MTT assay.Apoptosis detected flow cytometry with...
Plants are considered an important food and nutrition source for humans. Despite advances in plant seed metabolomics, knowledge about the genetic molecular bases of rice metabolomes at different developmental stages is still limited. Here, using Zhenshan 97 (ZS97) Minghui 63 (MH63), we performed a widely targeted metabolic profiling seeds during grain filling, mature germinating seeds. The diversity between MH63 ZS97 was characterized terms content metabolites shifting across stages. Taking...
Cancer stem cells (CSCs) have been implicated in metastasis, relapse, and therapeutic resistance of cancer, so successful cancer therapy may therefore require the development drugs against CSCs or combining anti-CSCs with conventional therapies. The phosphoinositide 3-kinase (PI3K) signaling pathway is one most frequently activated pathways human playing a central role tumorigenesis as well maintenance CSCs. Here, we designed identified B591, dihydrobenzofuran-imidazolium salt, novel...