A5100444567- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- PI3K/AKT/mTOR signaling in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolism, Diabetes, and Cancer
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Natural product bioactivities and synthesis
- Plant Pathogens and Fungal Diseases
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Chromatin Remodeling and Cancer
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- Nitric Oxide and Endothelin Effects
- Prostate Cancer Treatment and Research
- RNA regulation and disease
- Plant Toxicity and Pharmacological Properties
- Pharmacological Effects of Natural Compounds
- Protein Kinase Regulation and GTPase Signaling
- Angiogenesis and VEGF in Cancer
- NF-κB Signaling Pathways
Dana-Farber Cancer Institute
2011-2025
Harvard University
2011-2025
Brigham and Women's Hospital
2025
Konkuk University
2024
Chung-Ang University
2015-2024
University of Virginia
2004-2024
Sungkyunkwan University
2011-2024
Bio-Medical Science (South Korea)
2023-2024
Hanmi Pharmaceutical (South Korea)
2024
Resolve Therapeutics (United States)
2024
Cyclin D1 regulates G1 progression. Its transcriptional regulation is well understood. However, the mechanism underlying cyclin ubiquitination and its subsequent degradation not yet clear. We report that undergoes increased in cytoplasm during S phase a variety of cancer cells. This mediated by phosphorylation at Thr286 through activity Ras/Raf/MEK/ERK cascade F-box protein FBXW8, which an E3 ligase. The majority FBXW8 expressed phase. In contrast, accumulates nucleus exits into Increased...
Class Ia phosphatidylinositol 3 kinase (PI3K) is required for oncogenic receptor-mediated transformation; however, the individual roles of two commonly expressed class PI3K isoforms in receptor signaling have not been elucidated vivo. Here, we show that genetic ablation p110α blocks tumor formation both polyoma middle T antigen (MT) and HER2/Neu transgenic models breast cancer. Surprisingly, p110β results increased ductal branching tumorigenesis. Biochemical analyses suggest a competition...
Silica nanoparticles (SiNPs) are widely used for biosensing and diagnostics, the targeted delivery of therapeutic agents. Safety concerns about biomedical clinical applications SiNPs have been raised, necessitating analysis effects their intrinsic properties, such as sizes, shapes, surface physicochemical characteristics, on human health to minimize risk in applications. In particular, SiNP size-associated toxicological effects, underlying molecular mechanisms vascular endothelium remain...
One major challenge associated with lung cancer organoids (LCOs) is their predominant derivation from surgical specimens of patients early-stage cancer. However, advanced cancer, who are in need chemotherapy, often cannot undergo surgery. Therefore, there an urgent to successfully generate LCOs biopsy specimens. Conventional techniques, such as transthoracic needle and forceps biopsy, only yield small amounts tissue, resulting a low success rate for culturing samples. Furthermore, potential...
Abstract: In the present study, underlying protective mechanism of melatonin on kainic acid (KA)‐induced excitotoxicity was examined in hippocampus mice. KA, administered intracerebroventricularly (i.c.v.), induced marked neuronal cell death with concurrent microglial activation and subsequent induction inducible nitric oxide synthase (iNOS) hippocampus. Histopathological analysis demonstrated that (10 mg/kg), 1 hr prior to attenuated KA‐induced pyramidal neurons CA3 region. Melatonin...
Chromosome translocations and gene fusions are frequent events in the human genome have been found to cause diverse types of tumor. ChimerDB is a knowledgebase fusion genes identified from bioinformatics analysis transcript sequences GenBank various other public resources such as Sanger cancer project (CGP), OMIM, PubMed Mitelman's database. In this updated version, we significantly modified algorithm identifying transcripts. Specifically, new more sensitive has detected 2699 transcripts...
Abstract The disruption of the retinal pigment epithelium (RPE), for example, through oxidative damage, is a common factor underlying age-related macular degeneration (AMD). Aberrant autophagy also contributes to AMD pathology, as maintains RPE homeostasis ensure blood–retinal barrier (BRB) integrity and protect photoreceptors. Thioredoxin-interacting protein (TXNIP) promotes cellular stress by inhibiting thioredoxin reducing capacity in turn inversely regulated reactive oxygen species...
We have isolated five furanocoumarins, byakangelicin, phellopterin, imperatorin, isoimperatorin, and oxypeucedanin methanolate, from the roots of Angelica dahurica (Umbelliferae) prepared semi-synthesized compounds by partial reduction each furanocoumarin, effects these on lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2) production in rat peritoneal macrophages were examined. Among compounds, imperatorin showed most potent inhibitory activity LPS-induced PGE2 production. It also...
We have determined the complete mitochondrial genome of yellow-spotted long horned beetle, Psacothea hilaris (Coleoptera: Cerambycidae), an endangered insect species in Korea. The 15,856-bp P. mitogenome harbors gene content typical animal and a arrangement identical to most common type found mitogenomes. As with all other sequenced coleopteran species, 5-bp TAGTA motif was also detected intergenic space sequence located between tRNA(Ser)(UCN) ND1 hilaris. 1,190-bp non-coding A+T-rich region...
The principal objective of this study was to determine the relationship between preoperative coagulation tests and extent tumor involvement in gastric cancer patients.A total 110 patients with adenocarcinoma stomach were studied order evaluate relationship. Platelet count (P), prothrombin time (PT), activated partial thromboplastin time, D-dimer, fibrinogen degradation product, thrombin-antithrombin complex fragment F1+2 (F1+2) evaluated.The D-dimer levels positively correlated depth...
Recent work has shown that ablation of p110β, but not p110α, markedly impairs tumorigenesis driven by loss phosphatase and tensin homolog (PTEN) in the mouse prostate. Other laboratories have reported complementary data human prostate tumor lines, suggesting p110β activation is necessary for PTEN loss. Given multiple functions PTEN, we wondered if also sufficient tumorigenesis. Here, report transgenic expression a constitutively activated allele drives intraepithelial neoplasia formation....
This study examined the beneficial effects of n-butanol fraction and rutin extracted from tartary buckwheat (TB) on learning memory deficits in a mouse model amyloid β (Aβ)-induced Alzheimer's disease (AD). Learning were assessed using T-maze, object recognition, Morris water maze tests. Animals administered Aβ showed impaired cognition memory, which alleviated by oral administration an TB. Similarly, Aβ-induced increases nitric oxide formation lipid peroxidation brain, liver, kidneys...
Healthy expansion of adipose tissue maintains metabolic homeostasis by storing excess chemical energy in increased fat mass. The STAT5-PPAR gamma pathway reportedly regulates adipocyte differentiation, lipid metabolism and adipogenesis. Ginsenoside Rg3 is one the diverse groups steroidal saponins, major active components ginseng, which have demonstrated pharmacological properties. In this study, we evaluated therapeutic effects ginsenoside under pathological conditions vitro vivo We examined...
The tumor suppressor ARF enhances the SUMOylation of target proteins; however, physiological function ARF-mediated has been unclear due to lack a known, associated E3 SUMO ligase. Here we uncover TRIM28/KAP1 as novel ARF-binding protein and ligase for NPM1/B23. TRIM28 cooperate SUMOylate NPM1, nucleolar that regulates centrosome duplication genomic stability. NPM1 was attenuated by depletion enhanced overexpression. Coexpression promoted centrosomal localization enhancing its suppressed...
In this paper we describe the isolation of a cDNA that encodes human TFIIAα/β-likefactor (ALF). The open reading frame ALF predicts protein 478 amino acids contains characteristic N- and C-terminal conserved domains separated by an internal nonconserved domain. addition, rare ALF-containing cDNA, which possesses extended N terminus (Stoned B/TFIIAα/β-like factor; SALF) has also been identified. results Northern dot blot analyses show is expressed almost exclusively in testis; contrast,...