A5088880035- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Endoplasmic Reticulum Stress and Disease
- Alzheimer's disease research and treatments
- Advanced Sensor and Energy Harvesting Materials
- Tissue Engineering and Regenerative Medicine
- Nanocomposite Films for Food Packaging
- Marine Toxins and Detection Methods
- Muscle Physiology and Disorders
- RNA Interference and Gene Delivery
- Peripheral Neuropathies and Disorders
- Polydiacetylene-based materials and applications
- Pluripotent Stem Cells Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Exercise and Physiological Responses
- Neural dynamics and brain function
- Diabetic Foot Ulcer Assessment and Management
- Autophagy in Disease and Therapy
- interferon and immune responses
- Herpesvirus Infections and Treatments
Korea Institute of Science and Technology
2022-2025
National Institute of Animal Science
2021
The endoplasmic reticulum (ER) is selectively degraded by ER-phagy to maintain cell homeostasis. α-synuclein accumulates in the ER, causing ER stress that contributes neurodegeneration Parkinson’s disease (PD), but role of modulation largely unknown. Here, we investigated mechanisms which recognizes for degradation ER. We found played an important and recovery function through interaction with FAM134B, where calnexin required selective FAM134B-mediated clearance via ER-phagy. Overexpression...
This scientific investigation emphasizes the essential integration of nature’s influence in crafting multifunctional surfaces with bio-inspired designs for enhanced functionality and environmental advantages. The study introduces an innovative approach, merging color decoration, humidity sensing, antiviral properties into a unified surface using chitosan, organo-biological polymer, to create cost-effective multilayered films through sol-gel deposition UV photoinduced metal nanoparticles....
Abstract Dopamine (DA) affects voluntary movement by modulating basal ganglia function. In the classical model, DA depletion leads to overactivity of indirect pathway and excessively inhibits thalamus, resulting in hypokinesia. The contribution on striatopallidal synapses, an initial hub connecting striatum external globus pallidus (GPe), remains poorly understood because sparse innervation. Here, we combine optogenetic projection targeting, whole cell patch clamp recordings acute brain...
Stimulator of interferon genes (STING), a pivotal immune regulator, has emerged as contributor to nociception, yet its role in chronic pains remains still unknown. Here, we demonstrate that STING plays dual normal and neuropathic pain mature male rodents. maintains type I (IFN-I) level restraining sensitivity sham control, while activated STING/interferon regulatory factor 3 (IRF3) signaling increases the expression gamma-aminobutyric acid (GABA) transporter 1 (GAT1) spinal cord (SC), thus,...
Exerkines are soluble factors secreted by exercised muscles, mimicking the effects of exercise in various organs, including muscle itself. Lumican is reportedly from muscles; however, its roles skeletal remain unknown. Herein, we found that lumican mRNA expression extensor digitorum longus was significantly higher mice than unloading mice, and stimulated myogenesis vitro. Additionally, knockdown decreased mass cross-sectional area (CSA) fiber gastrocnemius mice. upregulated phosphorylation...
We identified a new human voltage-gated potassium channel blocker, NnK-1, in the jellyfish Nemopilema nomurai based on its genomic information. The gene sequence encoding NnK-1 contains 5408 base pairs, with five introns and six exons. coding of precursor is 894 nucleotides long encodes 297 amino acids containing presumptive ShK-like peptides. An electrophysiological assay demonstrated that fifth peptide, which was chemically synthesized, an effective blocker hKv1.3, hKv1.4, hKv1.5....
Parkinson’s disease (PD) is a neurodegenerative disorder with typical motor symptoms. Recent studies have suggested that excessive GABA from reactive astrocytes tonically inhibits dopaminergic neurons and reduces the expression of tyrosine hydroxylase (TH), key dopamine-synthesizing enzyme, in substantia nigra pars compacta (SNpc). However, DOPA decarboxylase (DDC), another relatively spared, raising possibility live but non-functional TH-negative/DDC-positive could be therapeutic target for...
Abstract An early appearance of reactive astrocytes is a hallmark Alzheimer’s disease (AD) 1,2 , providing substrate for diagnostic neuroimaging targets. However, there no clinically validated probe to visualize the astrogliosis in human brain vivo . Here, we report that PET/CT imaging with 11 C-acetate and 18 F-fluorodeoxyglucose ( F-FDG) functionally visualizes astrocyte-mediated neuronal hypometabolism brains neuroinflammation AD. We demonstrate excessively absorb acetate through elevated...
We have identified a new human voltage-gated potassium channel (hKv1.3) blocker, NnK-1, in the jellyfish Nemopilema nomurai, based on its genomic information. The gene sequence encoding NnK-1 contains 5,408 base pairs, with five introns and six exons. coding of precursor is 894 nucleotides long encodes 297 amino acids, containing presumptive ShK-like peptides. An electrophysiological assay demonstrated that chemically synthesized fifth peptide, an effective hKv1.3 blocker. A multiple...