A5028513740- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Autophagy in Disease and Therapy
- Neurobiology and Insect Physiology Research
- Parasitic Infections and Diagnostics
- Heme Oxygenase-1 and Carbon Monoxide
- interferon and immune responses
- Reproductive tract infections research
- Advanced Image and Video Retrieval Techniques
- Ocular Diseases and Behçet’s Syndrome
- Developmental Biology and Gene Regulation
- Data Management and Algorithms
- Reproductive System and Pregnancy
- Inflammasome and immune disorders
- Parasite Biology and Host Interactions
- Helminth infection and control
- Reproductive Physiology in Livestock
- Digital Holography and Microscopy
- Advanced Nanomaterials in Catalysis
- Invertebrate Immune Response Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Amoebic Infections and Treatments
- Coccidia and coccidiosis research
- Genetic Neurodegenerative Diseases
Chungnam National University
2016-2025
Guangdong Medical College
2021
Baylor College of Medicine
2007-2008
Korea Advanced Institute of Science and Technology
2002-2005
Tongmyong University
2002
Korea Institute of Science & Technology Information
2002
Seoul National University
1997-2000
University of North Carolina at Chapel Hill
1997
Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of the polyglutamine tract in huntingtin (Htt) protein. Neuronal toxicity HD thought to be, at least part, consequence protein interactions involving mutant Htt. We therefore hypothesized that genetic modifiers neurodegeneration should be enriched among Htt interactors. To test this idea, we identified comprehensive set interactors using two complementary approaches: high-throughput yeast two-hybrid...
Parkin, an E3 ubiquitin ligase, has been found to be responsible for autosomal recessive juvenile parkinsonism characterized primarily by selective loss of dopaminergic neurons with subsequent defects in movements. However, the molecular mechanisms underlying this neuron remain elusive. Here, we Drosophila parkin loss-of-function mutants, which exhibit shrinkage decreased tyrosine hydroxylase level and impaired locomotion. The behavioral defect mutant flies was partially restored...
To figure out the epidemiological status and relevance with other diseases in toxoplasmosis, we checked serum IgG antibody titers of 1,265 patients medical records seropositive patients. Seropositive rates were 6.6% by latex agglutination test (LAT) 6.7% ELISA. No significant differences detected between sexes age groups. The peak seroprevalence was 40-49-year-old group. According to clinical department, Toxoplasma-positive high psychiatry, ophthalmology, health management, emergency...
Two Drosophila tumor necrosis factor receptor-associated factors (TRAF), DTRAF1 and DTRAF2, are proposed to have similar functions with their mammalian counterparts as a signal mediator of cell surface receptors.However, in vivo related signaling pathways not fully understood yet.Here, we show that is an regulator c-Jun N-terminal kinase (JNK) pathway melanogaster.Ectopic expression the developing eye induced apoptosis, thereby causing rough-eye phenotype.Further genetic interaction analyses...
Nearest neighbor (NN) search is emerging as an important paradigm in a variety of applications which objects are represented vectors d numeric features. However, despite decades efforts, except for the filtering approach such VA-file, current solutions to find exact kNNs far from satisfactory large d. The represents compact approximations and by first scanning these smaller approximations, only small fraction real visited. In this paper, we introduce local polar coordinate file (LPC-file)...
Toxoplasma gondii results in ocular toxoplasmosis characterized by chorioretinitis with inflammation and necrosis of the neuroretina, pigment epithelium, choroid. After invasion, T. replicates host cells before cell lysis, which releases parasites to invade neighboring repeat life cycle establish a chronic retinal infection. The mechanism avoids innate immune defense, however, is unknown. Therefore, we determined whether PI3K/Akt signaling pathway activation essential for subversion immunity...
Toxoplasma gondii is distributed worldwide and infects most species of warm-blooded animals, including humans. The heavy incidence severe or lethal damage caused by T. infection clearly indicates the need for development a vaccine. To evaluate protective efficacy multiantigenic DNA vaccine expressing GRA7 ROP1 with without plasmid encoding murine interleukin-12 (pIL12), we constructed vaccines using eukaryotic plasmids pGRA7, pROP1, pGRA7-ROP1. Mice immunized pGRA7-ROP1 showed significantly...
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) are an important family of catalytic enzymes that generate reactive oxygen species (ROS), which mediate the regulation diverse cellular functions. Although phagocyte Nox2/gp91phox is closely associated with activation host innate immune responses, roles Nox protein during Toxoplasma gondii (T. gondii) infection have not been fully investigated. Here, we found T. gondii-mediated ROS production was required for upregulation...
Interleukin (IL)-23 and IL-12 are closely related in structure, these cytokines regulate both innate adaptive immunity. However, the precise signaling networks that production of each Toxoplasma gondii-infected THP-1 monocytic cells, particularly PI3K/AKT MAPK pathways, remain unknown. In present study, T. gondii infection upregulated expression IL-23 increased with parasite dose. secretion was strongly inhibited by TLR2 monoclonal antibody (mAb) treatment a dose-dependent manner siRNA...
The induction of host cell autophagy by various inducers contributes to the antimicrobial defense against Mycobacterium tuberculosis (Mtb), a major pathogenic strain that causes human tuberculosis. In this study, we present role for newly identified cyclic peptides ohmyungsamycins (OMS) A and B in responses Mtb infections activating murine bone marrow-derived macrophages (BMDMs). OMS robustly activated autophagy, which was essentially required colocalization LC3 autophagosomes with bacterial...
Toxoplasma gondii is an obligate intracellular parasite that stimulates production of high levels proinflammatory cytokines, which are important for innate immunity. NLRs, i.e., nucleotide-binding oligomerization domain (NOD)-like receptors, play a crucial role as immune sensors and form multiprotein complexes called inflammasomes, mediate caspase-1-dependent processing pro-IL-1β. To elucidate the inflammasome components in T. gondii-infected THP-1 macrophages, we examined...
Omega-3 polyunsaturated fatty acids (ω3-PUFAs) have potential protective activity in a variety of infectious diseases, but their actions and underlying mechanisms Toxoplasma gondii infection remain poorly understood. Here, we report that docosahexaenoic acid (DHA) robustly induced autophagy murine bone marrow-derived macrophages (BMDMs). Treatment T. gondii-infected with DHA resulted colocalization parasitophorous vacuoles autophagosomes reduced intracellular survival gondii. The autophagic...
External and internal stimuli easily affect the retina. Studies have shown that cells infected with Toxoplasma gondii are resistant to multiple inducers of apoptosis. Nanoparticles (NPs) been widely used in biomedical fields; however, little is known about cytotoxicity caused by NPs retina modulators inhibit nanotoxicity.ARPE-19 from human retinal pigment epithelium were treated silver nanoparticles (AgNPs) alone or combination T. gondii. Then, cellular toxicity, apoptosis, cell cycle...
Sirtuin 1 (SIRT1) regulates cellular processes by deacetylating non-histone targets, including transcription factors and intracellular signalling mediators; thus, its abnormal activation is closely linked to the pathophysiology of several diseases. However, function in Toxoplasma gondii infection unclear. We found that SIRT1 contributes autophagy via AMP-activated protein kinase (AMPK) PI3K/AKT pathways, promoting anti-Toxoplasma responses. Myeloid-specific Sirt1-/- mice exhibited an...
Cancer immunotherapy is widely used to treat various cancers augment the weakened host immune response against tumors. Dendritic cells (DCs) are specialized antigen-presenting that play dual roles in inducing innate and adaptive immunity. Toxoplasma gondii a protozoan parasite exhibits anti-tumor activity certain types of cancers. However, little known about effects T. or tumor/parasite antigen-pulsed DCs (DC vaccines, DCV) breast cancer. In this study, C57BL/6 mice were administered E0771...
Stimulator of interferon genes (STING), a pivotal immune regulator, has emerged as contributor to nociception, yet its role in chronic pains remains still unknown. Here, we demonstrate that STING plays dual normal and neuropathic pain mature male rodents. maintains type I (IFN-I) level restraining sensitivity sham control, while activated STING/interferon regulatory factor 3 (IRF3) signaling increases the expression gamma-aminobutyric acid (GABA) transporter 1 (GAT1) spinal cord (SC), thus,...