A5114889702- Virus-based gene therapy research
- Natural product bioactivities and synthesis
- Eicosanoids and Hypertension Pharmacology
- NF-κB Signaling Pathways
- Peroxisome Proliferator-Activated Receptors
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
- Hair Growth and Disorders
- Consumer Perception and Purchasing Behavior
- Ginseng Biological Effects and Applications
- Diverse Approaches in Healthcare and Education Studies
- Retinoids in leukemia and cellular processes
- Viral Infectious Diseases and Gene Expression in Insects
- Air Quality and Health Impacts
- Medicinal Plant Pharmacodynamics Research
- Bioactive Compounds and Antitumor Agents
- Magnolia and Illicium research
- Antioxidant Activity and Oxidative Stress
- CRISPR and Genetic Engineering
- Fatty Acid Research and Health
- Bioenergy crop production and management
- Anaerobic Digestion and Biogas Production
- Cancer-related molecular mechanisms research
- Plant Toxicity and Pharmacological Properties
Konkuk University
2020-2025
Korea Atomic Energy Research Institute
2024
Chungnam National University
2022
Kyung Hee University
2009-2013
Inje University
2008
Cinnamomum verum J. Presl (Cinnamon) is widely used in the food and pharmaceutical industries. C. exhibits various biological activities. However, it unclear whether can inhibit NOX, a major source of ROS generation, exert anti-inflammatory antioxidant effects PMA-stimulated THP-1 cells.This study investigates cells.The MeOH extract was analyzed using UPLC-QTOF/MS. Anti-inflammatory were examined by DCF-DA staining, immunofluorescence RT-PCR, immunoblotting cells.C. its components, cinnamic...
Sirtuin 1 (SIRT1) regulates cellular processes by deacetylating non-histone targets, including transcription factors and intracellular signalling mediators; thus, its abnormal activation is closely linked to the pathophysiology of several diseases. However, function in Toxoplasma gondii infection unclear. We found that SIRT1 contributes autophagy via AMP-activated protein kinase (AMPK) PI3K/AKT pathways, promoting anti-Toxoplasma responses. Myeloid-specific Sirt1-/- mice exhibited an...
11 S, 17S-dihydroxy 7,9,13,15,19 (Z,E,Z,E,Z)-docosapentaenoic acid (DoPE) is a derivative of docosapentaenoic acid, specialized pro-resolving mediator inflammation such as lipoxins, resolvins, maresins, and protectins. PM10 fine dust particle that induces oxidative stress, DNA damage, inflammation, aging, cancer. The anti-inflammatory mechanism DoPE, however, has not yet been elucidated. In these studies, we investigated whether DoPE effects in human keratinocyte HaCaT cells. We demonstrated...
Peroxisome proliferator-activated receptor-gamma (PPARγ) is a transcription factor involved in adipogenesis, and its transcriptional activity depends on ligands. Thiazolidinediones (TZDs), well-known PPARγ agonists, are drugs that improve insulin resistance type 2 diabetes. However, TZDs associated with severe adverse effects. As current therapies not well designed, novel agonists have been investigated adipocytes. (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP) known to...
(E)-2-methoxy-4-[3-(4-methoxyphenyl) prop-1-en-1-yl] phenol (MMPP), a novel synthetic analog of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal (BHPB), exerts anti-inflammatory and anticancer effects by downregulating the STAT3 pathway. It has also been recently reported that MMPP can act as PPAR agonist which enhances glucose uptake increases insulin sensitivity. However, it not yet elucidated whether an antagonist MD2 inhibit MD2-dependent pathways. In this study, we evaluated underlying modulatory...
Chronic skin inflammatory diseases are associated with abnormal immune responses characterized by barrier dysfunction. Keratinocytes participate in homeostasis regulated cells. Immune dysfunction contributes to the pathogenesis of mediated pro-inflammatory cytokines and chemokines, such as tumor necrosis factor (TNF)-α, which produced activated keratinocytes. 12(S)-Hydroxy eicosatetraenoic acid [12(S)-HETE], an arachidonic metabolite, has anti-inflammatory properties. However, role...
Abstract Background Oncolytic viruses are being studied and developed as novel cancer treatments. Using directed evolution technology, structural modification of the viral surface protein increases specificity oncolytic virus for a particular cell. Newcastle disease (NDV) does not show certain types cells during infection; therefore, it has low cell specificity. Hemagglutinin is an NDV receptor-binding on that determines host tropism. selectivity specific can be increased by artificial amino...
Glioblastoma (GBM) is one of the most lethal types human brain cancer and characterized by rapid growth, an aggressive nature a poor prognosis. GBM highly heterogeneous, often involves several genetic mutations abnormalities. Genetic disorders or low expression phosphatase tensin homolog (PTEN) are associated with occurrence, progression prognosis patients GBM. However, effective delivery PTEN for in cells within remains challenging. The aim present study was to develop therapeutic strategy...
Abstract Breast cancer is a frequently diagnosed and the leading cause of death among women worldwide. Tumor‐associated macrophages stimulate cytokines chemokines, which induce angiogenesis, metastasis, proliferation, tumor‐infiltrating immune cells. Although interleukin‐32 (IL‐32) has been implicated in development modulation several cancers, its function breast remains elusive. Mutation interleukin‐32θ (IL‐32θ) tissues patients with was detected by Sanger sequencing. RT‐qPCR used to detect...
The recently discovered interleukin (IL)- 32 isoform IL-32θ exerts anti-metastatic effects in the breast tumor microenvironment. However, involvement of cancer cell proliferation is not yet fully understood; therefore, current study aimed to determine how affects growth and evaluated responses IL-32θ-expressing cells other therapy. We compared functions triple-negative MDA-MB-231 that stably express IL-32θ, with transfected a mock vector. Slower was observed expressing than control cells,...
Human sepsis is one of the leading cause death worldwide and known to be a harmful damaging host inflammatory condition, primarily caused by endotoxin released gram-negative bacteria. Despite antibiotics administration being widely used treat disease, effective targeted therapeutic strategies for are still lacking. Here, we demonstrate that CM1, derivative natural polyphenol chrysin, exerts anti-inflammatory activity inducing ubiquitin-editing protein TNFAIP3 NAD-dependent deacetylase...
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and intractable cancer that requires more effective therapies can improve early detection, enhance treatment efficacy, provide better patient outcomes. Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations reduced phosphatase tensin (PTEN) protein expression are key factors driving the proliferation severity of PDAC. To address this, recombinant Newcastle disease virus (rNDV) containing PTEN gene (rNDV-PTEN) was created to...
Dandelion ( Taraxacum officinale ) a tranditional Oriental medicine, has been known to have anti‐atherogenic effects. However, the mechanism by which dandelion extracts protect against atherosclelosis is not clearly known. This study was designed explore effect of extract on inflammation and oxidative stress, risk factors early atherosclerosis development. Five group C57BL/6 mice were given atherogenic diet (control) or diets supplemented with 1.5%, 3% water (DWE I II) alcohol (DAE for 6...
Chronic inflammatory diseases of the skin are accompanied by abnormal immune responses, characterized barrier dysfunction. Keratinocytes participate in homeostasis, which is regulated cells. Dysfunction homeostasis contributes to pathogenesis diseases. These mediated pro-inflammatory cytokines and chemokines, such as tumor necrosis factor (TNF)-α, produced activated keratinocytes. 12(S)-Hydroxy eicosatetraenoic acid [12(S)-HETE], an arachidonic metabolite, expected have anti-inflammatory...