A5039448459- Cytokine Signaling Pathways and Interactions
- Peroxisome Proliferator-Activated Receptors
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Pharmacological Effects of Natural Compounds
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- Inflammatory mediators and NSAID effects
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- interferon and immune responses
- Genomics, phytochemicals, and oxidative stress
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Phytochemical compounds biological activities
- Metabolism, Diabetes, and Cancer
- Immune Cell Function and Interaction
- Redox biology and oxidative stress
- Electrochemical sensors and biosensors
- Phytochemistry and Bioactive Compounds
- Retinoids in leukemia and cellular processes
- Eicosanoids and Hypertension Pharmacology
- Animal Virus Infections Studies
Konkuk University
2016-2025
Sookmyung Women's University
2017
Kwangwoon University
2000-2016
Seoul National University
2007-2015
Korea Research Institute of Bioscience and Biotechnology
2000-2014
Konkuk University Medical Center
2013
Gangneung–Wonju National University
2011
Chungbuk National University
2011
Rice University
2009
Forest Research Institute
2009
IL-32 is a recently discovered cytokine that induces TNFα, IL-1β, IL-6, and chemokines. We investigated whether expressed in the synovia of patients with rheumatoid arthritis (RA) studied associations disease severity presence other cytokines. Immunohistochemistry revealed highly RA synovial tissue biopsies, whereas was not observed tissues from osteoarthritis. Moreover, biopsies 29 active disease, level staining correlated erythrocyte sedimentation rate, marker systemic inflammation ( R =...
Initially described in 1989 as interferon-gamma (IFN-gamma) inducing factor (IGIF), interleukin-18 (IL-18) is a novel pro-inflammatory cytokine that clearly more than an inducer of IFN-gamma. The possesses several biological properties such activation nuclear factor-kappaB (NF-kappaB), Fas ligand expression, the induction both CC and CXC chemokines, increased production competent human immunodeficiency virus. Most activities are due to receptor complex recruits IL-1 receptor-activating...
The activation of innate immunity requires the amplification signals induced by pattern-recognition receptors for bacterial products. We have investigated role newly described cytokine IL-32 in production two most clinically relevant families microbial receptors, cell-surface Toll-like (TLRs) and intracellular nuclear oligomerization domain (NOD) receptor family. synergized with NOD1- NOD2-specific muropeptides peptidoglycans release IL-1β IL-6 (a 3- to 10-fold increase). In contrast, did...
Background Interleukin (IL)–32 is a newly described proinflammatory cytokine that seems likely to play role in inflammation and host defense. Little known about the regulation of IL-32 production by primary cells immune system. Methods Findings In present study, freshly obtained human peripheral blood mononuclear were stimulated with different Toll-like receptor (TLR) agonists, gene expression synthesis was determined. We demonstrate TLR4 agonist lipopolysaccharide induces moderate (4-fold)...
Summary Cytokines are crucial in host defence against pathogens such as bacteria, viruses, fungi and parasites. A newly described cytokine, interleukin‐32 (IL‐32), induces various proinflammatory cytokines (tumour necrosis factor‐α, IL‐1β, IL‐6) chemokines both human mouse cells through the nuclear factor‐κB p38 mitogen‐activated protein kinase inflammatory signal pathway. The IL‐32 primarily acts on monocytic rather than T cells. In an attempt to isolate soluble receptor, we used...
Cinnamomum verum J. Presl (Cinnamon) is widely used in the food and pharmaceutical industries. C. exhibits various biological activities. However, it unclear whether can inhibit NOX, a major source of ROS generation, exert anti-inflammatory antioxidant effects PMA-stimulated THP-1 cells.This study investigates cells.The MeOH extract was analyzed using UPLC-QTOF/MS. Anti-inflammatory were examined by DCF-DA staining, immunofluorescence RT-PCR, immunoblotting cells.C. its components, cinnamic...
Abstract NK cells are a key component of innate immune systems, and their activity is regulated by cytokines hormones. Adiponectin, which secreted from white adipose tissues, plays important roles in various diseases, including hypertension, cardiovascular inflammatory disorders, cancer. In this study the effect adiponectin on cell was investigated. Adiponectin found to suppress IL-2-enhanced cytotoxic without affecting basal cytotoxicity inhibit IL-2-induced NF-κB activation via...
Luteolin is a common flavonoid that exists in medicinal herbs, fruits, and vegetables. has biochemical functions including anti-allergy, anti-inflammation, anti-cancer functions. However, its efficacy precise mode of action against breast cancer are still under study. To elucidate whether luteolin exhibits an anticancer effect cancer, MCF-7 cells were incubated with luteolin, apoptosis was assessed by observing nuclear morphological changes performing cell viability assay, cycle analysis,...
Abstract Cervical carcinoma is the predominant cancer among malignancies in women throughout world, and human papillomavirus (HPV) 16 most common agent linked to cervical carcinoma. The present study was performed investigate mechanisms of immune escape HPV-induced cells. presence HPV oncoproteins E6 E7 extracellular fluids HPV-containing cell lines SiHa CaSki demonstrated by ELISA. effect on production IFN-γ IL-18 assessed. proteins reduced IL-18-induced both primary PBMCs NK0 line. FACS...
Overweight and obesity lead to an increased risk for metabolic disorders such as impaired glucose regulation/insulin resistance, dyslipidemia, hypertension. Several molecular drug targets with potential prevent or treat have been revealed. Interestingly, the activation of peroxisome proliferator-activated receptor (PPAR), which belongs nuclear superfamily, has many beneficial clinical effects. PPAR directly modulates gene expression by binding a specific ligand. All subtypes (alpha, gamma,...
Summary A new proinflammatory cytokine interleukin‐32 (IL‐32) has six isoforms. Although IL‐32 can be detected in sera from patients suffering Crohn’s disease and rheumatoid arthritis, it is unclear which isoforms are involved. To this end, we investigated the functions of most abundant IL‐32β by generating K562‐IL‐32β stable cell lines. This report confirms, using small interfering RNA, that induces an anti‐inflammatory IL‐10 cells U937 promonocytic cells, express endogenous upon phorbol...
Inflammatory cytokines mediate inflammatory bowel diseases (IBDs) and cytokine blocking therapies often ameliorate the disease severity. IL-32 affects inflammation by increasing production of IL-1, TNFα, several chemokines. Here, we investigated role in intestinal generating a transgenic (TG) mouse expressing human IL-32γ (IL-32γ TG). Although TG mice are healthy, constitutive serum colonic tissue levels TNFα elevated. Compared with wild-type (WT) mice, exhibited modestly exacerbated acute...
To understand modulation of a novel immune‐related cytokine, interleukin‐18, by human papillomavirus type (HPV) 16 oncogenes, HaCaT, normal keratinocyte cell line, and C‐33A, HPV‐negative cervical cancer were prepared to establish stable lines expressing E6, E6 mutant (E6m), E6E7, or E7 constitutively. Expressions various HPV oncogene transcripts identified RT‐PCR. Expression was reversely correlated the expression pro‐inflammatory cytokine. The in independent splicing, resulted decreased...