A5024864962- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Diet and metabolism studies
- Animal Virus Infections Studies
- Peroxisome Proliferator-Activated Receptors
- Psoriasis: Treatment and Pathogenesis
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant Molecular Biology Research
- Blood Coagulation and Thrombosis Mechanisms
- Testicular diseases and treatments
- Immune Response and Inflammation
- Drug Transport and Resistance Mechanisms
- Barrier Structure and Function Studies
Korea Food Research Institute
2016-2024
Konkuk University
2009-2019
Konkuk University Medical Center
2010-2013
Dermatology Research Center
2010
Inflammatory cytokines mediate inflammatory bowel diseases (IBDs) and cytokine blocking therapies often ameliorate the disease severity. IL-32 affects inflammation by increasing production of IL-1, TNFα, several chemokines. Here, we investigated role in intestinal generating a transgenic (TG) mouse expressing human IL-32γ (IL-32γ TG). Although TG mice are healthy, constitutive serum colonic tissue levels TNFα elevated. Compared with wild-type (WT) mice, exhibited modestly exacerbated acute...
IL-33/IL-1F11 is a new member of the IL-1 family ligand and provokes T helper-type immune responses. IL-33 ST2 receptor accessory protein (IL-1RAcP) that triggers nuclear factor-κ light chain enhancer activated B cells (NF-κB) MAPK signaling. We discovered novel short splice variant was termed spIL-33. The spIL-33 lacks exon 3 containing proposed caspase-1 cleavage site. isolated cDNA from Huh7 human hepatocarcinoma cell line expressed recombinant in Escherichia coli. pro-IL-33 were not...
IL-1 family ligand does not possess a typical hydrophobic signal peptide and needs processing enzyme for maturation. The maturation process of IL-33 (IL-1F11), new member the ligand, remains unclear. Precursor affinity column isolates neutrophil proteinase 3 (PR3) from human urinary proteins. PR3 is known ligand-processing IL-1β (IL-1F2) IL-18 (IL-1F4), including other inflammatory cytokines. We investigated in precursor because we isolated by using column. converted inactive mouse proteins...
Gellan gum (GG) is an anionic polysaccharide used as additive in the food industry. However, effect of GG on gut microbiota regulation and nonalcoholic fatty liver disease (NAFLD) has not yet been investigated. In vitro fermentation experiments have demonstrated that promoted growth probiotic strains such Lactiplantibacillus rhamnosus Bifidobacterium bifidum, producing metabolites beneficial to health. mice, reduced hepatic triglyceride content, serum biomarkers, body fat mass weight gain...
Dietary habits and gut microbiota play an essential role in non-alcoholic fatty liver disease (NAFLD) related factors such as insulin resistance de novo lipogenesis. In this study, we investigated the protective effects of
Abstract α 1 -Antitrypsin (AAT) is a member of the serine proteinase inhibitor family that impedes enzymatic activity proteinases, including human neutrophil elastase, cathepsin G and 3. Here, we expressed recombinant AAT by fusing intact gene to constant region IgG1 generate soluble AAT-Fc protein. The protein was produced in Chinese hamster ovary (CHO) cells purified using mini-protein A affinity chromatography. Recombinant tested for antiinflammatory function sufficiently suppressed tumor...
Cryptorchidism, a condition in which testes fail to descend from the abdomen into scrotum, is risk factor for infertility and germ cell cancer. Normally, tight junctions between adjacent Sertoli cells form blood–testes barrier that regulates spermatogenesis; however, effect of cryptorchidism on not well-understood. We established model heat-induced testicular damage dogs using surgical cryptorchidism. sequenced RNA investigate whether certain transcripts are expressed at higher rates...
Cytokines are significantly associated with the homeostasis of immune responses in health and disease. Interleukin-32 (IL-32) is a cytokine originally discovered natural killer cell transcript 4. IL-32 different disorders has been described terms pathogenesis progression diseases. Clinical studies have investigated under various conditions, such as viral infection, autoimmune diseases, inflammatory certain types cancer, vascular disease, pulmonary The high expression was identified tissues...
Type 1 diabetes is considered to be an autoimmune disease in which T cells attack pancreatic islet cells. Impaired glucose tolerance with type 2 has been classified as obesity-associated metabolic syndrome. However, recent studies have revealed that autoinflammatory due imbalance of inflammatory cytokine production and related molecular components cause inflammation. Insulin-like growth factor (IGF) the insulin-like factor-binding protein-3 (IGFBP3) system are known involved development...
Yacon, Smallanthus sonchifolius, has anti-hypertensive, anti-inflammatory, and anti-cancer potential. However, its neuroprotective anti-neuroinflammatory effects are unknown. Moreover, activation of microglia been considered a mechanism in the development Alzheimer's disease. Therefore, aim this study was to determine an ethanolic yacon leaf extract (YLE) on lipopolysaccharide (LPS)-induced neuroinflammation vitro vivo. The viability microglial BV2 cells tested with...
It has been reported that fatty acid binding proteins (FABPs) do not act only as intracellular mediators of lipid responses but also have extracellular functions. This study aimed to investigate whether liver type (L)-FABP a biological activity and determined serum L-FABP levels in patients with end-stage renal disease (ESRD). We isolated complementary deoxyribonucleic (cDNA) from the Huh7 human hepatocarcinoma cell line expressed recombinant protein Escherichia coli. A549 lung carcinoma...
Although the immune enhancing effect of yeast has been widely reported, studies specifically investigating its effects on skin cancer are lacking. Therefore, this study aimed to develop a extract capable inhibiting melanoma cells using ultrasound technology, which can lyse cell walls allowing subsequent rapid extraction. To compare extraction efficiency across different methods, total yield, as well glucan, α-glucan, and β-glucan yields were measured. Ultrasound-assisted (UAEY) was found...
Cytokines are essential coordinators of defensive immune responses for resolving the invasion pathogens such as bacteria, virus, and fungi. However, dysregulated cytokines main cause various autoinflammatory disorders rheumatoid arthritis, inflammatory bowel disease, psoriasis. Interleukin-32 (IL-32) is a recently described cytokine characterized proinflammatory cytokine. IL-32 stimulates monocytes macrophages to induce important (IL-1β, IL-6, TNFα) chemokines (IL-8 MIP-2) by activating...