A5030890160- Parkinson's Disease Mechanisms and Treatments
- Zebrafish Biomedical Research Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Ginkgo biloba and Cashew Applications
- Glycosylation and Glycoproteins Research
- Alzheimer's disease research and treatments
- Spinal Dysraphism and Malformations
- Sleep and Wakefulness Research
- Immune Response and Inflammation
- PI3K/AKT/mTOR signaling in cancer
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Proteoglycans and glycosaminoglycans research
- Protein Kinase Regulation and GTPase Signaling
- Autophagy in Disease and Therapy
- Circadian rhythm and melatonin
- Carbohydrate Chemistry and Synthesis
- Cholesterol and Lipid Metabolism
- Lysosomal Storage Disorders Research
Inha University
2023-2024
Yonsei University
2021-2023
The endoplasmic reticulum (ER) is selectively degraded by ER-phagy to maintain cell homeostasis. α-synuclein accumulates in the ER, causing ER stress that contributes neurodegeneration Parkinson’s disease (PD), but role of modulation largely unknown. Here, we investigated mechanisms which recognizes for degradation ER. We found played an important and recovery function through interaction with FAM134B, where calnexin required selective FAM134B-mediated clearance via ER-phagy. Overexpression...
This study aimed to elucidate the role of O-GlcNAc cycling in 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease (PD)-like neurodegeneration and underlying mechanisms. We observed dose-dependent downregulation O-GlcNAcylation, accompanied by an increase O-GlcNAcase following 6-OHDA treatment both mouse brain Neuro2a cells. Interestingly, elevating O-GlcNAcylation through glucosamine (GlcN) injection provided protection against PD pathogenesis induced 6-OHDA. At behavioral level, GlcN...
Abstract This study investigated chronic and repeated sleep deprivation (RSD)-induced neuronal changes in hexosamine biosynthetic pathway/ O -linked N-acetylglucosamine (HBP/ -GlcNAc) cycling of glucose metabolism further explored the role altered -GlcNAc promoting neurodegeneration using an adult zebrafish model. RSD-triggered degenerative brain led to impairment memory, neuroinflammation amyloid beta (Aβ) accumulation. Metabolite profiling RSD revealed a significant decrease glucose,...
Sleep deprivation (SD) is widely acknowledged as a significant risk factor for cognitive impairment. In this study, intraperitoneal caffeine administration significantly ameliorated the learning and memory (L/M) deficits induced by SD reduced aggressive behaviors in adult zebrafish. led to reduction protein kinase A (PKA) phosphorylation, phosphorylated-cAMP response element-binding (p-CREB), c-Fos expression zebrafish brain. Notably, these alterations were effectively reversed caffeine....
ABSTRACT This study explores the 24‐h rhythmic cycle of protein O ‐GlcNAcylation within brain and highlights its crucial role in regulating circadian neuronal function based on zebrafish as an animal model. In our experiments, disruption rhythm, achieved through inversion light‐dark or daytime melatonin treatment, not only impaired changes along with altering expression patterns ‐GlcNAc transferase (OGT) ‐GlcNAcase (OGA) but also significantly impeded learning memory function. particular,...
Adult neurogenesis is the process of generating new neurons to enter neural circuits and differentiate into functional neurons. However, it significantly reduced in Parkinson's disease (PD). Uric acid (UA), a natural antioxidant, has neuroprotective properties patients with PD. This study aimed investigate whether UA would enhance PD.We evaluated elevating serum levels 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonian mouse model restore subventricular zone (SVZ). For...
Elevated blood glucose is associated with an increased risk of atherosclerosis. Data from the current study showed that glucosamine (GlcN), a normal metabolite hexosamine biosynthetic pathway (HBP), promoted lipid accumulation in RAW264.7 macrophage cells. Oleic acid- and lipopolysaccharide (LPS)-induced was further enhanced by GlcN cells, although there no significant change rate fatty acid uptake. acetyl CoA carboxylase (ACC), synthase (FAS), scavenger receptor class A, liver X receptor,...
This study investigated the behavioral and molecular changes in telencephalon following needle stab-induced injury optic tectum of adult zebrafish. At 3 days post-injury (dpi), there was noticeable structural damage to brain tissue reduced neuronal proliferation that persisted until 30 dpi. Neurobehavioral deficits observed at dpi included decreased exploratory social activities impaired learning memory (L/M) functions; all these resolved by 7 The led a reduction telencephalic phosphorylated...
<title>Abstract</title> This study aimed to elucidate the role of <italic>O</italic>-GlcNAc cycling in 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease (PD)-like neurodegeneration and underlying mechanisms. We observed dose-dependent downregulation <italic>O</italic>-GlcNAcylation, accompanied by an increase <italic>O</italic>-GlcNAcase following 6-OHDA treatment both mouse brain Neuro2a cells. Intriguingly, elevation <italic>O</italic>-GlcNAcylation through glucosamine (GlcN)...
Abstract Adult neurogenesis is the process of generating new neurons to enter neural circuits and differentiate into functional neurons. However, it significantly reduced in Parkinson’s disease (PD). Restoring suggested be a potential disease-modifying strategy treat PD. Uric acid (UA), natural antioxidant, has neuroprotective properties patients with Here, we hypothesized that UA would enhance by modulating mitochondria, dynamic organelles key regulators fate stem cells. We evaluated...