A5063847168- Advanced biosensing and bioanalysis techniques
- Silicon Nanostructures and Photoluminescence
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Nanowire Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Carbon and Quantum Dots Applications
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Pluripotent Stem Cells Research
- Luminescence and Fluorescent Materials
- Bacteriophages and microbial interactions
- Ferroptosis and cancer prognosis
- Nanoparticle-Based Drug Delivery
- Microfluidic and Bio-sensing Technologies
- Extracellular vesicles in disease
- Graphene and Nanomaterials Applications
- Analytical Chemistry and Sensors
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Photocatalysis Techniques
- Advanced Biosensing Techniques and Applications
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- TiO2 Photocatalysis and Solar Cells
Ulsan National Institute of Science and Technology
2019-2025
Institute for Basic Science
2023-2025
University of California, San Diego
2013-2025
Asan Medical Center
2016-2020
University of Ulsan
2016-2020
Ulsan College
2016-2020
Government of the Republic of Korea
2019-2020
Seoul Institute
2020
University of California System
2016
Pohang University of Science and Technology
2006-2014
Deformable semi-solid liquid metal particles (LMP) have emerged as a promising substitute for rigid conductive fillers due to their excellent electrical properties and stable conductance under strain. However, achieving compact robust coating of LMP on fibers remains persistent challenge, mainly the incompatibility conventional techniques with LMP. Additionally, limited durability absence initial conductivity restrict widespread application. In this study, we propose solution process that...
Wound healing in cases of excessive inflammation poses a significant challenge due to compromised neovascularization. Here, we propose multi-functional composite hydrogel engineered overcome such conditions through recruitment and activation macrophages with adapted degradation the hydrogel. The (G-TSrP) is created by combining gelatin methacryloyl (GelMA) nanoparticles (TSrP) composed tannic acid (TA) Sr2+. These are prepared using one-step mineralization process assisted metal-phenolic...
Traumatic brain injury (TBI) is a major health and socio-economic problem, but no pharmacological agent currently approved for the treatment of acute TBI. Thus, there great need advances in this field. Here, we describe short peptide (sequence CAQK) identified by vivo phage display screening mice with injury. The CAQK selectively binds to injured mouse human brain, systemically injected specifically homes sites models. target proteoglycan complex upregulated injuries. Coupling increased site...
Calcium ions react with silicic acid released from dissolving porous silicon nanoparticles to create an insoluble calcium silicate shell. The shell traps and protects siRNA payload, which can be delivered neuronal tissues in vitro or vivo. Gene delivery is enhanced by the action of targeting cell-penetrating peptides attached
The luminescence lifetime of nanocrystalline silicon is typically on the order microseconds, significantly longer than nanosecond lifetimes exhibited by fluorescent molecules naturally present in cells and tissues. Time-gated imaging, where image acquired at a time after termination an excitation pulse, allows discrimination nanoparticle probe from these endogenous signals. Because microsecond scale for emission, time-gated imaging relatively simple to implement this biocompatible nontoxic...
Size‐controlled porous silicon‐based nanoparticles are prepared by pulsed electrochemical etching of single crystal silicon wafers, followed ultrasonic fracture the freestanding layer. When high‐current density pulses applied periodically during layer process, a multilayer results in which layers separated thin much higher porosity. Ultrasonic selectively cleaves film along these high‐porosity perforations, providing greater size control and improved yields (by 5x) resulting nanoparticles....
A chemically targeted luminescent porous silicon–graphene oxide core–shell nanoparticle delivers siRNA for more effective gene silencing.
Abstract Extracellular matrix (ECM) proteins containing cell‐attachable Arg‐Gly‐Asp (RGD) sequences exhibit variable bridging and non‐bridging in fibronectin‐collagen laminin‐collagen complexes that can regulate inflammation, tissue repair, wound healing. In this study, linking molecule‐mediated conjugation of 1D magnetic nanocylinders (MNCs) to material surfaces pre‐decorated with gold nanospheres (GNSs) is performed, thereby yielding RGD‐coated MNCs (RGD‐MNCs) over GNSs (RGD‐GNSs) a state....
Organ-on-a-chip, which recapitulates the dynamics of in vivo vasculature, has emerged as a promising platform for studying organ-specific vascular beds. However, its practical advantages identifying vascular-targeted drug delivery systems (DDS) over traditional vitro models remain underexplored. This study demonstrates reliability and efficacy organ-on-a-chip screening efficient DDS by comparing performance with that conventional transwell, both designed to simulate blood–brain barrier...
We report a facile and sensitive analytical method for the detection of pathogenic bacteria. Salmonella bacteria in milk were captured by antibody-conjugated magnetic nanoparticles (MNPs) separated from analyte samples applying an external field. The MNP–Salmonella complexes re-dispersed buffer solution then exposed to antibody-immobilized TiO2 nanocrystals (TNs), which absorb UV light. After magnetically separating MNP–Salmonella–TN solution, UV-Vis absorption spectrum unbound TN was...
Abstract A major obstacle in luminescence imaging is the limited penetration of visible light into tissues and interference associated with scattering autofluorescence. Near‐infrared (NIR) emitters that can also be excited NIR radiation via two‐photon processes mitigate these factors somewhat because they operate at wavelengths 650–1000 nm where are more transparent, less efficient, endogenous fluorophores likely to absorb. This study presents photolytically stable, photoluminescent, porous...
A systematic study on the activation of photoluminescence from luminescent porous silicon nanoparticles (LPSiNPs) by oxidation in aqueous media containing sodium tetraborate (borax) is presented. The treatment promotes surface skeleton and consequently generates an electronically passivated material. Photoluminescence ascribed to quantum confinement effects defects localized at Si‐SiO 2 interface, strong attributed passivation nonradiative defects. (carried out 20 °C) a gradual blue shift...
Blood-brain barrier (BBB) remains one of the critical challenges in developing neurological therapeutics. Short single-stranded DNA/RNA nucleotides forming a three-dimensional structure, called aptamers, have received increasing attention as BBB shuttles for efficient brain drug delivery owing to their practical advantages over Trojan horse antibodies or peptides. Aptamers are typically obtained by combinatorial chemical technology, termed Systemic Evolution Ligands EXponential Enrichment...
Abstract Neural probe engineering is a dynamic field, driving innovation in neuroscience and addressing scientific medical demands. Recent advancements involve integrating nanomaterials to improve performance, aiming for sustained vivo functionality. However, challenges persist due size, stiffness, complexity, manufacturing intricacies. To address these issues, neural interface utilizing freestanding CNT‐sheets drawn from CNT‐forests integrated onto thermally functional polymer fibers...
We developed a novel gravimetric immunoassay for sensitive detection of multiple protein biomarkers using silicon microcantilever arrays and multifunctional hybrid nanoparticles. Magnetic-photocatalytic nanoparticles with highly crystalline TiO(2) shell were synthesized solvothermal reaction without calcination process. After functionalizing the cantilevers antibodies, used to magnetically separate target from human serum. Frequency changes microcantilevers due binding measured dip-and-dry...
The effect of supercritical drying (SCD) on the preparation porous silicon (pSi) powders has been investigated in terms photoluminescence (PL) efficiency. Since pSi contains closely spaced and possibly interconnected Si nanocrystals (<5 nm), pore collapse morphological changes within nanocrystalline structure after common processes can affect PL We report highly beneficial effects using SCD for photoluminescent powders. Significantly higher surface areas volumes have realized by...
Colorectal cancer (CRC) is the second-leading cause of cancer-related mortality worldwide, which may be effectively reduced by early screening. Colon secreted protein-2 (CCSP-2) a promising blood marker for CRC. An electric-field effect colorectal sensor (E-FECS), an ion-sensitive field-effect transistor under dual gate operation with nanostructure developed, to quantify CCSP-2 directly from patient samples. The sensing performance E-FECS verified in 7 controls and CRC samples, it clinically...