A5101983557- Vestibular and auditory disorders
- Ophthalmology and Eye Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Asthma and respiratory diseases
- Glaucoma and retinal disorders
- Migraine and Headache Studies
- Cerebral Venous Sinus Thrombosis
- Peripheral Neuropathies and Disorders
- Neuroscience of respiration and sleep
- Allergic Rhinitis and Sensitization
- Multiple Sclerosis Research Studies
- Mast cells and histamine
- Alcoholism and Thiamine Deficiency
- Neurological and metabolic disorders
- IL-33, ST2, and ILC Pathways
- Ear Surgery and Otitis Media
- Myasthenia Gravis and Thymoma
- Tactile and Sensory Interactions
- Neurological disorders and treatments
- Blood Pressure and Hypertension Studies
- Infectious Encephalopathies and Encephalitis
- Glycogen Storage Diseases and Myoclonus
- Respiratory and Cough-Related Research
- Neurological Complications and Syndromes
- Pharmacological Effects and Toxicity Studies
Chonbuk National University Hospital
2015-2025
Jeonbuk National University
2015-2025
Kyung Hee University
2022-2025
National Cancer Center
2023
Asan Medical Center
2023
Ulsan College
2023
Kosin University
2008-2023
University of Ulsan
2023
Kunsan National University
2022
National University College
2008-2020
Abstract Allergic asthma is characterized by airway inflammation initiated adaptive immune responses to aeroallergens. Recent data suggest that severe may be a different form of rather than an increase in symptoms and innate LPS can modulate allergens. In this study, we evaluated the hypothesis exposure doses induces asthma. Our study showed neutrophilic IFN-γ expression were higher induced sputum from patients mild moderate asthmatics. Animal experiments indicated allergen sensitization...
To determine the immediate and long-term therapeutic efficacies of Gufoni head-shaking maneuvers in apogeotropic type benign paroxysmal positional vertigo involving horizontal semicircular canal (HC-BPPV), a randomized, prospective, sham-controlled study was conducted.In 10 nationwide dizziness clinics Korea, 157 consecutive patients (95 women, age range: 18-89 years, mean ± SD = 59.9 13.6) with HC-BPPV were randomized to (n 52), 54), or sham maneuver 51). For maneuver, underwent...
Background: Research on the optimal duration of immunosuppressive therapy (IST) and outcome upon its discontinuation in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remains limited. Objective: To evaluate outcomes following IST MOGAD. Methods: This multicenter retrospective study collected data from 333 MOGAD patients Korea. Among 273 who received IST, 41 discontinued were analyzed. Results: The median age at onset was 38.3 years (interquartile range (IQR),...
Background and Purpose— Isolated nodular infarction has rarely been described in human. The purpose of this study is to report clinical laboratory findings isolated infarction. Methods— Eight patients with were recruited from 6 hospitals Korea. All underwent a complete standardized neurotological evaluation including ocular torsion, bithermal caloric tests, rotatory chair test addition MRI MR angiography. Results— presented vertigo moderate severe imbalance. most common manifestation was...
Abstract Objectives: To determine chronological characteristics of vestibular recovery after neuritis (VN) by using various clinical parameters. Study Design: Prospective study. Methods: Twenty 22 consecutive patients with acute VN underwent serial follow‐ups static (spontaneous nystagmus, subjective visual vertical, and ocular torsion) dynamic (head‐shaking nystagmus [HSN], vibration‐induced [VIN], head thrust test, caloric test) imbalances for 1 year symptom onset. Results: Static improved...
Horizontal head shaking at 2 to 3 Hz can induce nystagmus in patients with central as well peripheral vestibulopathy. However, the characteristics and diagnostic value of this post-head-shaking (HSN) have not been studied systematically vestibulopathy, little is known mechanisms involved.We analyzed spontaneous HSN effects baclofen, a GABA(B) agonist, 16 acute lateral medullary infarction.These showed several unlike those observed was 14 (87.5%), all cases, horizontal component beats toward...
<h3>Objectives:</h3> To determine the immediate and long-term therapeutic efficacies of barbecue rotation Gufoni maneuvers, a randomized, prospective, sham-controlled study was conducted in patients with geotropic type benign paroxysmal positional vertigo involving horizontal semicircular canal (HC-BPPV). <h3>Methods:</h3> In 10 nationwide dizziness clinics Korea, 170 consecutive (107 women, age range 11−97 years, mean ± SD 61 15 median = years) HC-BPPV were randomly assigned to (n 56), 64),...
Systemic inflammatory response syndrome (SIRS) is a fundamental host common to bacterial infection and sterile tissue injury. can cause organ dysfunction death, but its mechanisms are incompletely understood. Moreover, SIRS progress failure or death despite being after control of the inciting infection. Biomarkers discriminating between sepsis, SIRS, postinfective would therefore help direct care. Circulating mitochondrial DNA (mtDNA) damage-associated molecular pattern reflecting cellular...
No previous studies have investigated the relationship between various anti-ganglioside antibodies and clinical characteristics of Guillain-Barré syndrome (GBS) in Korea. The aim this study was to determine prevalence types Korean GBS patients, identify their significance. Serum collected from patients during acute phase at 20 university-based hospitals laboratory findings were reviewed compared with detected antibody. Among 119 60 positive for immunoglobulin G (IgG) or M against any type...
<h3>Objective</h3> To assess the effect of vitamin D and calcium supplementation in preventing recurrences benign paroxysmal positional vertigo (BPPV). <h3>Methods</h3> We performed an investigator-initiated, blinded-outcome assessor, parallel, multicenter, randomized controlled trial 8 hospitals between December 2013 May 2017. Patients with confirmed BPPV were randomly assigned to intervention (n = 518) or observation 532) group after successful treatment canalith repositioning maneuvers....
Abstract IL-13 is a critical cytokine at sites of Th2 inflammation. In these locations it mediates its effects via receptor complex, which contains IL-4Rα and IL-13Rα1. A third, high-affinity receptor, IL-13Rα2, also exists. Although was initially felt to be decoy this has not been formally demonstrated the role(s) recently become controversial. To define IL-13Rα2 in IL-13-induced pulmonary inflammation remodeling, we compared lung-targeted transgenic mice with wild-type null loci. We...
Chronic inflammatory airway diseases including asthma are characterized by immune dysfunction to inhaled allergens. Our previous studies demonstrated that T cell priming allergens requires LPS, which is ubiquitously present in household dust In this study, we evaluated the role of vascular endothelial growth factor (VEGF) development and its polarization Th1 or Th17 cells when exposed LPS-contaminated An mouse model was induced sensitization with then challenged alone. Therapeutic...
Abstract Xylitol, a natural sweetener, can be produced by hydrogenation of xylose in hemicelluloses. In microbial processes, utilization only NADPH cofactor limited commercialization xylitol biosynthesis. To overcome this drawback, Saccharomyces cerevisiae D452‐2 was engineered to express two types reductase (XR) with either NADPH‐dependence or NADH‐preference. Engineered S. DWM expressing both the XRs exhibited higher productivity than yeast strain NADPH‐dependent XR (DWW) batch and...
Objective: Intravenous contrast agent enhanced, high-resolution magnetic resonance imaging of the inner ear (iMRI) confirmed that patients with Menière's disease (MD) and vestibular migraine (VM) could present endolymphatic hydrops (EH). The study aimed to investigate EH characteristics their interrelation neurotologic testing in VM, MD, or VM concurrent MD (VM-MD). Methods: Sixty–two (45 females, aged 23–81 years) definite probable ( n = 25, 19 definite), 29, 17 showing both diseases 8)...
Background Myelin oligodendrocyte glycoprotein antibody (MOG) immunoglobulin G (IgG)-associated disease (MOGAD) has clinical and pathophysiological features that are similar to but distinct from those of aquaporin-4 (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (AQP4-NMOSD). MOG-IgG AQP4-IgG, mostly the IgG1 subtype, can both activate complement system. Therefore, we investigated whether levels serum components, regulators, activation products differ between MOGAD AQP4-NMOSD,...
Persistent postural-perceptual dizziness (PPPD) is a chronic functional vestibular disorder for which the Bárány Society has established diagnostic criteria. This nationwide multicenter study aims to investigate clinical features of individuals with definite PPPD and variant who do not fully meet criteria, particular focus on visual exaggeration.
<h3>Introduction</h3> In the last decade, increasing research interest has been expressed in responsive behaviours of older adults living long-term care (LTC) homes, including nursing homes and assisted facilities. Responsive are not only a sign underlying unmet needs, but when directed against (towards) paid staff can lead to decreased quality work life, may contribute lower care. this systematic review, we aim synthesise empirically based quantitative qualitative evidence on factors...