A5031505816- Acute Ischemic Stroke Management
- Peripheral Neuropathies and Disorders
- Cerebrovascular and Carotid Artery Diseases
- Epilepsy research and treatment
- Multiple Sclerosis Research Studies
- Neurological and metabolic disorders
- Botulinum Toxin and Related Neurological Disorders
- Advanced Radiotherapy Techniques
- Pharmacological Effects and Toxicity Studies
- Infectious Encephalopathies and Encephalitis
- Pain Mechanisms and Treatments
- Autoimmune Neurological Disorders and Treatments
- Hereditary Neurological Disorders
- Radiation Therapy and Dosimetry
- Myasthenia Gravis and Thymoma
- Stroke Rehabilitation and Recovery
- Systemic Lupus Erythematosus Research
- Musculoskeletal pain and rehabilitation
- Alcoholism and Thiamine Deficiency
- Medical Imaging Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Orthopedic Surgery and Rehabilitation
- Peripheral Nerve Disorders
Eulji University
2015-2025
CHA University
2025
Seoul National University Hospital
2005-2021
University of Wisconsin–Madison
2021
Eulji General Hospital
2004-2017
Yonsei University
2008
Kongju National University
2008
Ewha Womans University
2008
Korea University
2005
DNA Link (South Korea)
2005
<i>Background:</i> Little information is available regarding the risk factors for intracranial cerebral atherosclerosis (ICAS), particularly among asymptomatics. <i>Methods:</i> Data from a consecutive series of 1,208 subjects aged ≧40 years, with no history stroke, and who had undergone transcranial Doppler ultrasonography (TCD) were collected prospectively. The role classic was assessed in presence severity asymptomatic ICAS, which determined by TCD....
No previous studies have investigated the relationship between various anti-ganglioside antibodies and clinical characteristics of Guillain-Barré syndrome (GBS) in Korea. The aim this study was to determine prevalence types Korean GBS patients, identify their significance. Serum collected from patients during acute phase at 20 university-based hospitals laboratory findings were reviewed compared with detected antibody. Among 119 60 positive for immunoglobulin G (IgG) or M against any type...
Background: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD). Objective: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea. Methods: Anti-aquaporin-4 antibody-positive (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The divided into two groups based on age onset: (⩾50 years at onset) versus early-onset (EO-NMOSD) (<50 onset). Clinical, laboratory, and magnetic resonance imaging...
Inhospital medical complications account for a considerable portion of deaths during the early stage stroke. However, relatively few studies have examined their long-term effects on mortality in stroke patients.We prospectively and consecutively collected data 579 patients with acute ischemic from November 1998 to February 2001. Mortality was confirmed using national death certificate 1999 2003.During admission, one or more requiring intervention developed 160 these (27.6%). For subjects,...
Obesity affects female reproductive performance by impairing the ovarian and uterine environments. Using a diet-induced obesity mouse model, we examined whether high-fat diet (HFD) regimen gene expression profile in granulosa cells (GCs) short-term HFD has similar effects on as long-term HFD. C57BL/6J mice were fed or normal (ND) for 16–18 weeks (long-term group) 4 (short-term group). GCs collected from each group of RNA-sequencing. RT-PCR immunofluorescence staining performed to validate...
Treatments for neuromyelitis optica spectrum disorder (NMOSD) such as eculizumab, ravulizumab, satralizumab, and inebilizumab have significantly advanced relapse prevention, but they remain expensive. Rituximab is an off-label yet popular alternative that offers a cost-effective solution, its real-world efficacy needs better quantification guiding the application of newer approved NMOSD treatments (ANTs). This study aimed to determine rituximab failure rates anticipate demand ANTs aid in...
Acquired myasthenia gravis (MG) is a prototype autoimmune disease of the neuromuscular junction, caused in most patients by autoantibodies to muscle nicotinic acetylcholine receptor (AChR). There seem be ethnic and regional differences frequency clinical features MG seronegative for AChR antibody. This study aimed describe autoantibody profiles Korean with generalized A total 62 high index suspicion were identified from 18 centers, we examined their sera antibodies clustered AChR,...
Both vertebrobasilar dolichoectasia (VBD) and cerebral microbleeds (CMBs) are related with the risk of intracerebral hemorrhage. We aimed to examine relationship between VBD CMB in ischaemic stroke patients.A consecutive series 182 patients hospitalized because or transient attack (TIA), who underwent gradient echo brain magnetic resonance imaging were retrospectively recruited from a prospective registry. locations categorized into anterior posterior circulation. Ectasia was defined as...
The association of <i>APOE</i> genotypes with cerebral microbleeds (CMBs) was examined on the basis location CMBs in 414 patients who were admitted primarily because stroke. With respect to possession ε2 or ε4 allele, adjusted odds ratio 1.94 (1.05 3.58) for lobar but 1.21 (0.69 2.11) nonlobar CMBs. This suggests that pathogenesis may differ depending their location.
We aimed to evaluate the diagnostic accuracy of enzyme-linked immunosorbent assay (ELISA) for anti-muscle specific tyrosine kinase (MuSK) antibody (Ab) in a large cohort anti-acetylcholine receptor (AChR) Ab-negative generalized myasthenia gravis (MG), and also investigate clinical contexts diagnosis MuSK MG.A retrospective study 160 patients with suspicion AChR MG was performed. The serum samples were tested anti-clustered Ab by cell-based (CBA), anti-MuSK ELISA, CBA and/or...
Purpose: To evaluate the prevalence of proximal vertebral artery stenosis, compared with those distal vertebral/basilar and extracranial internal carotid artery, in a large population stroke non‐stroke patients. Material Methods: Nine‐hundred‐and‐thirty‐five patients who underwent high‐resolution contrast‐enhanced magnetic resonance angiography regional general hospital were categorized into six groups based on neurological symptoms disease: an asymptomatic group ( n = 182), minor symptom...
Vitamin B6 is closely associated with functions of the nervous, immune, and endocrine systems. Its deficiency may result in neurological disorders including convulsions epileptic encephalopathy. Until today, this has only been reported infants, children, critically ill adult patients. We report a case 36year-old man chronic alcoholism who presented seizures after gastrointestinal disturbance. His persisted even treatment antiepileptic drugs, but eventually disappeared administration...
Mitofusin 2 ( MFN2 ) gene encodes an outer mitochondrial membrane protein which plays a central role in fusion.1 Mutations the have recently been reported to cause up 33% of axonal peripheral neuropathies some cases involved CNS.2,3 Since initial study, linked mutations with Charcot-Marie-Tooth disease type 2A (CMT2A),4 also found CMT optic atrophy (CMT6).5 prevents cell death following DNA damage and K+ deprivation induced apoptosis beyond its fusion.6 Furthermore, it has that fusion defect...
Encephalitis is caused by multiple organisms, but rarely the hepatitis A virus.A 27-year-old man visited our hospital because of fever, altered consciousness, and seizures.On physical exam, a stuporous mentality neck stiffness were found.On laboratory elevated liver enzymes cerebrospinal fluid abnormalities, including pleocytosis protein levels observed.The virus (HAV) IgM antibody was also detected.We conclude that these findings compatible with encephalitis associated HAV discuss...
We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using live cell–based assay for MOG AQP4 antibodies. Of 586 IDDs CNS, 36 (6.1%) 185 (31.6%) tested positive antibodies, respectively. No participant showed double positivity. Seroprevalence was about five times...
Abstract Motor unit number estimations (MUNEs) can directly assess motor populations in muscle and quantify the degree of physiological or pathological degeneration. A high reproducibility reliability is required any effective quantitative tool. MUNE being increasingly applied clinically, statistical has several advantages over alternative techniques. Nevertheless, optimal method applying with respect to its not been established. We performed by selecting most compensated compound action...
The clinical implications of myelin oligodendrocyte glycoprotein autoantibodies (MOG-Abs) are increasing. Establishing MOG-Ab assays is essential for effectively treating patients with MOG-Abs. We established an in-house cell-based assay (CBA) to detect MOG-Abs identify correlations patients' characteristics.We the CBA using HEK 293 cells transiently overexpressing full-length human MOG, tested it against 166 samples from a multicenter registry central nervous system (CNS) inflammatory...
We present a Korean case of Hirayama disease with its typical neuroradiological findings forward displacement cervical dural sac and compression the lower cord during neck flexion. A 15-yr-old boy was presented one-year history progressive weakness atrophy affecting bilateral hands forearms. The electrodiagnostic were compatible lesion anterior horn cells at C7, C8, T1 spinal segments. With flexion, magnetic resonance imaging (MRI) showed shifting resulting in those Presumably, this might...