A5040307279- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginseng Biological Effects and Applications
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Neuropeptides and Animal Physiology
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Circadian rhythm and melatonin
- Adenosine and Purinergic Signaling
- Nerve injury and regeneration
- Biochemical effects in animals
- Parkinson's Disease Mechanisms and Treatments
- Biological and pharmacological studies of plants
- Genomics, phytochemicals, and oxidative stress
- Selenium in Biological Systems
- Cholinesterase and Neurodegenerative Diseases
- Ginkgo biloba and Cashew Applications
- Biochemical Acid Research Studies
- Neuroendocrine regulation and behavior
- Trace Elements in Health
- Pharmacogenetics and Drug Metabolism
- Mitochondrial Function and Pathology
Konkuk University
2015-2025
Kangwon National University
2015-2024
Government of the Republic of Korea
2018
Foundation for Biomedical Research and Innovation
2015
Meijo University
2015
Chung-Ang University
2015
Zero to Three
2009
Nagoya University Hospital
2005
Ginseng extracts show cognition-enhancing effects in Alzheimer's disease (AD) patients. However, little is known about the active components and molecular mechanisms of how ginseng exerts its effects. Recently, we isolated a novel lysophosphatidic ac
Activation of NADPH oxidase (PHOX) plays a critical role in mediating dopaminergic neuroinflammation. In the present study, we investigated PHOX methamphetamine (MA)-induced neurotoxic and inflammatory changes mice. We examined mitogen-activated protein kinases (MAPKs), mitochondrial function [i.e., membrane potential, intramitochondrial Ca2+ accumulation, oxidative burdens, superoxide dismutase expression, translocation cleaved form kinase C delta type (cleaved PKCδ)], microglial activity,...
Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disorder with unknown cause, but it has been suggested that neuroinflammation may play role in pathogenesis of the disease. Neuroinflammatory component process PD neurodegeneration was proposed by postmortem, epidemiological and animal model studies. However, remains unclear how neuroinflammatory factors contribute to dopaminergic neuronal death PD.In this study, we analyzed relationship among inducible nitric oxide...
We demonstrated that oxidative stress plays a crucial role in cognitive impairment klotho mutant mice, genetic model of aging. Since down-regulation melatonin due to aging is well documented, we used this determine whether the antioxidant property affects memory impairment. First, examined effects on hippocampal parameters and glutathione/oxidized glutathione (GSH/GSSG) ratio dysfunction mice. Second, investigated specific receptor involved melatonin-mediated pharmacological response by...
Abstract We have demonstrated that mitochondrial oxidative damage and PKCδ overexpression contribute to methamphetamine‐induced dopaminergic degeneration. Although it is recognized antioxidant melatonin effective in preventing neurotoxicity induced by methamphetamine, its precise mechanism remains elusive. C57BL/6J wild‐type mice exhibited a similar degree of deficit when methamphetamine was administered during light dark phases. Furthermore, neuroprotection genetic inhibition the phase...
Hyeon-Joong Kim, Eun-Joo Shin, Byung-Hwan Lee, Sun-Hye Choi, Seok-Won Jung, Ik-Hyun Cho, Sung-Hee Hwang, Joon Yong Jung-Soo Han, ChiHye Chung, Choon-Gon Jang, Hyewon Rhim, Hyoung-Chun and Seung-Yeol Nah. Mol. Cells 2015;38:796-805. https://doi.org/10.14348/molcells.2015.0116
Abstract Recently, we have demonstrated that ginsenoside Re protects methamphetamine (MA)‐induced dopaminergic toxicity in mice via genetic inhibition of PKCδ and attenuation mitochondrial stress. In addition, reported induction glutathione peroxidase (GPx) is also important for neuroprotection mediated by Re. To extend our knowledge, examined the effects against MA vitro condition using SH‐SY5Y neuroblastoma cells. Treatment with resulted significant attenuations a decrease activity GPx an...
We investigated the neuroprotective property of analogs dextromethorphan (DM) in lipopolysaccharide (LPS) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models to identify drugs for Parkinson's disease (PD).In vivo studies showed that daily injections with DM protected dopamine (DA) neurons substantia nigra pars compacta restored DA levels striatum using two different PD.Of five studied, 3-hydroxymorphinan (3-HM), a metabolite DM, was most potent, neuronal loss depletion up 90%...