A5006436119- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Autoimmune Neurological Disorders and Treatments
- Medical Image Segmentation Techniques
- Cell Image Analysis Techniques
- MXene and MAX Phase Materials
- Neurogenetic and Muscular Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Genetic Neurodegenerative Diseases
- Genomic variations and chromosomal abnormalities
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Alzheimer's disease research and treatments
- Systemic Lupus Erythematosus Research
- Hearing Loss and Rehabilitation
- Fuel Cells and Related Materials
- Electron Spin Resonance Studies
- Traditional Chinese Medicine Studies
- Viral Infections and Immunology Research
- Advanced MRI Techniques and Applications
Children's Hospital of Philadelphia
2020-2025
The cerebrospinal fluid (CSF) provides a unique glimpse into the central nervous system (CNS) compartment and offers insights immune processes associated with both healthy surveillance as well inflammatory disorders of CNS. latter include demyelinating disorders, such multiple sclerosis (MS) myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), that warrant different therapeutic approaches yet are not always straightforward to distinguish on clinical imaging grounds alone....
Purpose Thalamic nuclei are largely invisible in conventional MRI due to poor contrast. Thalamus Optimized Multi‐Atlas Segmentation (THOMAS) provides automatic segmentation of 12 thalamic using white‐matter‐nulled (WMn) Magnetization Prepared Rapid Gradient Echo (MPRAGE) sequence at 7T, but increases overall scan duration. Routinely acquired, bias‐corrected 2 (MP2RAGE) yields superior tissue contrast and quantitative T1 maps. Application THOMAS MP2RAGE has been investigated this study....
OBJECTIVE We evaluated performance on the Penn Computerized Neurocognitive Battery (PCNB), a tool assessing accuracy and response time across four cognitive domains, alongside Symbol Digit Modalities Test (SDMT), measure of processing speed commonly used in MS. determined whether decrements are more likely to be detected measures versus pediatric-onset multiple sclerosis (POMS). METHODS Performance SDMT, PCNB tests belonging domains (executive function, episodic memory, complex cognition,...
The limbic system is involved in memory and processing of emotional stimuli. We measured volume the hippocampus, amygdala, thalamus, assessed their relative contribution to episodic emotion identification POMS. Sixty-five POMS participants (Mage = 18.3 ± 3.9 years; 48 female (73.8%)), average disease duration 3.8 years) 76 age- sex-matched controls 18.1 4.6 49 (64.5%)) completed Penn Computerized Neurocognitive Battery (PCNB); 59 65 69 out underwent 3 T MRI scanning. derived age-adjusted...
Opsoclonus myoclonus ataxia syndrome (OMAS) is a rare disorder that causes significant neurodevelopmental sequelae in children. Approximately half of pediatric OMAS cases are paraneoplastic, typically associated with localized neuroblastic tumors. Since early persistence or relapse symptoms common even after tumor resection, relapses may not routinely prompt reevaluation for recurrent We report 12-year-old girl recurrence decade initial treatment. Providers should be aware as trigger distant...
To describe CSF levels of neurofilament-light chain (NfL), glial fibrillary acidic protein (GFAP) and Tau in a cohort patients with wide spectrum disease severity age at time treatment initiation, both baseline following nusinersen.
Several proton magnetic resonance spectroscopy ( 1 H-MRS) based studies have reported regional alterations of glutamate metabolism in both acute and chronic multiple sclerosis (MS) pathologies, including normal appearing white matter mixed tissues. Despite its well-established capability for detecting altered metabolism, H-MRS is hampered by the low spatial resolution that precludes measurements from small MS lesions. We demonstrate feasibility performing weighted imaging using chemical...
Purpose: Thalamic nuclei are largely invisible in conventional MRI due to poor contrast. Thalamus Optimized Multi-Atlas Segmentation (THOMAS) provides automatic segmentation of 12 thalamic using white-matter-nulled (WMn) MPRAGE sequence at 7T. Application THOMAS Magnetization Prepared 2 Rapid Gradient Echo (MP2RAGE) acquired 7T has been investigated this study. Methods: 8 healthy volunteers and 5 pediatric-onset multiple sclerosis patients were recruited the Children's Hospital Philadelphia...