A5030480668- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Hematopoietic Stem Cell Transplantation
- Neuroblastoma Research and Treatments
- Pharmaceutical studies and practices
- Testicular diseases and treatments
- Glioma Diagnosis and Treatment
- Viral Infections and Immunology Research
- Biochemical and Molecular Research
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Blood disorders and treatments
- Adolescent and Pediatric Healthcare
- Blood groups and transfusion
- Extracellular vesicles in disease
- Computational Drug Discovery Methods
- Mosquito-borne diseases and control
- Viral-associated cancers and disorders
- Neonatal Health and Biochemistry
Tata Medical Center
2016-2025
University of Manchester
2009-2024
Indian Agricultural Research Institute
2024
Cancer Research UK Manchester Institute
2007-2023
University Children's Hospital Zurich
2022
Dhaka Shishu Hospital
2022
Manchester Academic Health Science Centre
2010-2021
ICAR - Central Island Agricultural Research Institute
2019
University of Malaya
2012-2018
Advanced Centre for Treatment, Research and Education in Cancer
2017
Abstract Background In the west, survival following treatment of childhood acute lymphoblastic leukaemia (ALL) approaches 90%. Outcomes in India do not exceed 70%. To address this disparity, Indian Collaborative Childhood Leukaemia group (ICiCLe) developed 2013 a contemporary protocol for uniform risk-stratified management first presentation ALL based on cytogenetics and minimal residual disease levels (MRD). A multicentre randomised clinical trial opened 2016 (ICiCLe-ALL-14) examines...
Background. Japanese encephalitis is a major public health problem in Asia. However, there little data on the long-term outcome of survivors. Methods. We prospectively evaluated children with serologically confirmed over an 8.3-year period. The patients were assessed and their outcomes graded functional score at hospital discharge follow-up appointments. examined how patient compared that visits, when changes occurred, prognostic indicators eventual outcome. Results. One hundred eighteen...
l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There wide individual variation in pharmacokinetics, and little known about its metabolism. The mechanisms failure with l-asparaginase remain speculative. Here, we now report that 2 lysosomal cysteine proteases present lymphoblasts are able to degrade l-asparaginase. Cathepsin B (CTSB), which produced constitutively by normal leukemic cells, degraded asparaginase Escherichia coli (ASNase)...
AimOutcomes of children with high-risk (HR) relapsed acute lymphoblastic leukaemia (ALL) (N = 393), recruited to ALLR3 and ALL-REZ BFM 2002 trials, were analysed. Minimal residual disease (MRD) was assessed after induction at predetermined time points until haematopoietic stem cell transplantation (SCT).MethodsGenetic analyses included karyotype, copy-number alterations mutation analyses. Ten-year survivals analysed using Kaplan-Meier Cox models for multivariable analyses.ResultsOutcomes...
The outcomes of Central Nervous System (CNS) relapses in children with acute lymphoblastic leukaemia (ALL) treated the ALL R3 trial, between January 2003 and March 2011 were analysed. Patients risk stratified, to receive a matched donor allogeneic transplant or fractionated cranial irradiation continued treatment for two years. A randomisation Idarubicin Mitoxantrone closed December 2007 favour Mitoxantrone. estimated 3-year progression free survival combined isolated CNS disease 40.6%...
The ALLR3 trial investigated outcomes of children with B-cell precursor acute lymphoblastic leukaemia who had late bone marrow relapses. We analysed long-term follow-up these patients.
Significance Germ-line mutation in the tumor suppressor TP53 causes Li–Fraumeni syndrome (LFS), a complex predisposition to multiple cancers. Types of cancers and ages at diagnosis vary among subjects families, with apparent genetic anticipation: i.e., earlier cancer onset successive generations. It has been proposed that anticipation is caused by accumulation copy-number variations (CNV) context haploinsufficiency. Using genome/exome sequencing, we found no evidence increased rates CNVs two...
Introduction: For diagnosis, sub-categorization and follow up of Acute Leukemia (AL), phenotypic analysis using flow cytometry is mandatory.
 Material methods: We retrospectively analyzed immunophenotypic data along with cytogenetics/molecular genetics (wherever available) from 631 consecutive cases AL diagnosed at our laboratory January 2014 to August 2017.
 Results: Of the total cases, 52.9% (n=334) were acute lymphoblastic leukemia (ALL), 43.9% (n=277) myeloid (AML), 2.2% (n=14)...
Background: Outcomes of children with acute lymphoblastic leukaemia (ALL) in the west approach 90%. Treated on same protocols, outcomes India, were ~65%.
// Jizhong Liu 1 , Ashish Masurekar Suzanne Johnson Sohini Chakraborty 2 John Griffiths 3 Duncan Smith Seema Alexander Clare Dempsey Catriona Parker Stephanie Harrison Yaoyong Li 4 Crispin Miller Yujun Di Zhumur Ghosh Shekhar Krishnan 1, 5 Vaskar Saha Children's Cancer Group, Institute of Science, Manchester Academic Health Sciences Centre, University Manchester, United Kingdom Bioinformatics Bose Institute, Kolkata, India Mass Spectrometry Service, Research UK Applied Computational Biology...
The north and north-eastern regions of India have among the highest incidence gallbladder cancer (GBC) in world. We report clinicopathological charateristics outcome GBC patients India.Electronic medical records diagnosed with at Tata Medical Center, Kolkata between 2017 2019 were analyzed.There 698 cases confirmed a median age 58 (IQR: 50-65) years female:male ratio 1.96. At presentation, 91% (496/544) had stage III/IV disease 30% (189/640) incidental GBC. 2-year overall survival (OS) was...
Introduction: The Direct Antiglobulin Test (DAT) is a screening technique used to detect Immunoglobulin G (IgG) antierythrocyte antibodies on foetal Red Blood Cells (RBCs). Universal bilirubin decreases the incidence of severe hyperbilirubinemia. diagnostic efficacy DAT in cases ABO incompatibility not well established, contrast Rh incompatibility. Aim: To evaluate ability routine cord blood neonates ≥35 weeks gestation with predicting requirement for phototherapy. Additionally, compare...
Gallbladder cancer (GBC) while rare worldwide has a high prevalence in India. Pathogenesis is unclear and outcomes poor. cholangiocyte organoids (GCOs) or gallbladder carcinoma (GBCOs) were developed serially propagated from surgically resected tissues with benign malignant diseases, respectively. Patient derived (PDOs) 15 normal; 58 inflamed; 12 xanthogranulomatous cholecystitis (XGC); 5 pre-invasive neoplasm 13 invasive pathologies. Protocol optimisation achieved 58% (69/119) success...
Summary Japanese encephalitis virus (JEV) is an important in Asia, but there are few data on Malaysia. A hospital‐based surveillance system for (JE) has been operation Sarawak, Malaysia, the last 10 years. JEV endemic with cases occurring throughout year and a seasonal peak quarter (one‐way anova , P < 0.0001). Ninety‐two per cent of 133 were children aged 12 years or younger; introduction JE vaccination July 2001 reduced number (84 four seasons prior to vs. 49 six after, McNemar’s test,...
We report the virological and clinical features of 8 children who presented with adenovirus-associated acute flaccid paralysis (AFP) during an epidemic enterovirus type 71 (EV71)-associated hand-foot-and-mouth disease (HFMD) in Sarawak, Malaysia, 1997. Neutralization tests phylogenetic analysis revealed adenovirus 21 (Ad21), although DNA restriction digests suggested that this virus was different from prototype Ad21. Four had upper-limb monoparesis, 2 lower-limb monoparesis (one whom changes...
Pediatric medulloblastoma (MB) treatment has evolved over the past few decades; however, treating children in countries with limited resources remains challenging. Until now, literature regarding childhood MB Malaysia been nonexistent. Our objectives were to review demographics and outcome of pediatric treated at University Malaya Medical Center between January 1994 December 2013 describe challenges encountered.Fifty-one patients seen Center. Data from 43 analyzed; eight excluded because...
Background Flow cytometry (FCM) is a simple, sensitive, and specific technique that can potentially determine DNA ploidy in B‐cell precursor ALL (BCP‐ALL) complementary to cytogenetics. Methods A prospective FCM analysis using FxCycle™ Violet (assay sensitivity 0.01%) was done 125 consecutive new cases of BCP‐ALL (90 <15 years age) compared with corresponding cytogenetic (karyotyping and/or FISH) data wherever available. This assay also subsequently evaluated for detection residual...