A5027981934- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Ethics and Legal Issues in Pediatric Healthcare
- Palliative Care and End-of-Life Issues
- Adolescent and Pediatric Healthcare
- Global Cancer Incidence and Screening
- Acute Myeloid Leukemia Research
- Family Support in Illness
- Pharmaceutical studies and practices
- Lymphoma Diagnosis and Treatment
- DNA Repair Mechanisms
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Renal and related cancers
- Health Systems, Economic Evaluations, Quality of Life
- T-cell and B-cell Immunology
- Chronic Myeloid Leukemia Treatments
- Global Health and Surgery
- Neuroblastoma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Oral health in cancer treatment
- Prenatal Screening and Diagnostics
The Christie Hospital
2001-2023
University of Manchester
2011-2023
Children with Cancer UK
2018
Manchester Academic Health Science Centre
2011-2012
National Cancer Research Institute
2004-2011
University College Hospital
2011
University of Hull
2011
University College London Hospitals NHS Foundation Trust
2011
University College London
2011
Hull York Medical School
2011
Corticosteroids are an essential component of treatment for acute lymphoblastic leukaemia (ALL). Prednisolone is the most commonly used steroid, particularly in maintenance phase therapy. There increasing evidence that, even equipotent dosage glucocorticoid effect, dexamethasone has enhanced lymphoblast cytotoxicity and penetration central nervous system (CNS) compared with prednisolone. Substitution prednisolone ALL might, therefore, result improved event-free overall survival. Children...
There is an inequality gap between the outcome of childhood cancer in resource, rich and limited countries. Abandonment treatment one reasons for this.We searched medical literature evidence on abandonment, its causes, any preventative interventions.Abandonment a very real problem all across developing world. Cancers associated with poorer prognosis seem to have higher abandonment rates. It also related socio-economic educational status parents, travel time centers, affordable, locally...
Summary This study of children and adults with acute lymphoblastic leukaemia (ALL) is the largest series patients hypodiploidy (<46 chromosomes) yet reported. The incidence 5% was independent age. Patients were subdivided by number chromosomes; near‐haploidy (23–29 chromosomes), low (33–39 high (42–45 chromosomes). near‐haploid hypodiploid groups characterized their chromosomal gains a doubled hyperdiploid population. Structural abnormalities more frequent in group. Near‐haploidy...
Around 25% of all tumors in those 0–14 years age and 9% 15–24 involve the CNS. They are most common cause cancer-related deaths both groups. In adults 25–84 age, proportion CNS is 2%; 5-year overall survival 10%–15%; survivors have considerable morbidity. Comprehensive up-to-date population-based incidence data on these lacking. We present rates for primary based derived from high-quality national cancer registration system England. A total 54,336 malignant, benign, uncertain behavior were...
To test the hypothesis that reduced exposure to common infections in first year of life increases risk developing acute lymphoblastic leukaemia. Design and setting The United Kingdom childhood cancer study (UKCCS) is a large population based case-control across 10 regions UK.
This, the sixth official document of SIOP Working Committee on psychosocial issues in pediatric oncology, develops another important and especially difficult topic: assistance for terminally ill children with cancer. This is provided oncology community as a useful set guidelines. It should be always possible declining child to die without unnecessary physical pain, fear, or anxiety. essential that he she receive adequate medical, spiritual, psychological support, at no point feels abandoned....
Abstract Background Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of pathological cells, for which the aetiology and pathogenesis remain largely unknown. Procedure Information on 101 children with LCH registered population‐based Manchester Children's Tumour Registry (MCTR) between 1954 1998 was extracted from records MCTR. This included age, sex, date diagnosis, systems affected at diagnosis follow‐up. Results The overall incidence rate 2.6 cases per million child...
The United Kingdom Childhood Cancer Study was designed to examine the relation between childhood cancer and preceding exposure infectious diseases. authors analyzed diagnosis (1991–1996) of acute lymphoblastic leukemia (ALL) at ages 2–5 years clinically diagnosed infections in infancy. Almost all study children (96% both cases controls) were taken a general practitioner for non-immunization-associated visit least once before their first birthday. Children with ALL had significantly more...
A retrospective analysis of children with first relapse acute lymphoblastic leukaemia (ALL), treated on the UKALL R2 protocol at four different hospitals, between June 1995 and December 2002 was performed. Of 150 139 (93%) achieved a second complete remission. The overall survival (OS) event-free (EFS) for whole group 56% 47% respectively. duration remission immunophenotype, but not sites relapse, were predictive survival. Using Berlin-Frankfürt-Münster risk stratification relapsed ALL, OS...
Abstract Purpose: The HOX genes comprise a large family of homeodomain-containing transcription factors, present in four separate clusters, which are key regulators embryonic development, hematopoietic differentiation, and leukemogenesis. We aimed to study the role DNA methylation as an inducer gene silencing leukemia. Experimental Design: Three hundred seventy-eight samples myeloid lymphoid leukemia were quantitatively analyzed (by COBRA analysis pyrosequencing bisulfite-modified DNA) for...
l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There wide individual variation in pharmacokinetics, and little known about its metabolism. The mechanisms failure with l-asparaginase remain speculative. Here, we now report that 2 lysosomal cysteine proteases present lymphoblasts are able to degrade l-asparaginase. Cathepsin B (CTSB), which produced constitutively by normal leukemic cells, degraded asparaginase Escherichia coli (ASNase)...
Abstract BACKGROUND: It is believed that gonadal and extragonadal germ cell tumors (GCTs) arise from primordial cells may have similar etiopathogenesis. Unlike testicular GCTs, there has been limited comprehensive population‐based analysis of ovarian GCTs. METHODS: All malignant GCTs all central nervous system (CNS) with benign uncertain behavior were registered in England the age group 0 to 84 years 1979 2003 included current study. Incidence rates calculated adjusted world standard...
Given the huge disparity in chance of survival for children with cancer born low income countries (LICs) compared those high ones, there is an urgent need to assist striving support, palliate and offer curative treatment resource limited settings. International twinning partnerships opportunity provide advice, expertise, support technology transfer from established paediatric oncology units developing ones order help them overcome challenges facing them. It may avoid mistakes made over last...
This is the tenth official document of SIOP Working Committee on psychosocial issues in pediatric oncology, instituted 1991. It addressed to oncology community. Children clearly have a right participate medical decisions regarding their own treatment, based developmental level child. The objective these guidelines encourage physicians share with child developmentally relevant information specific that particular child's health status, context culture, so he or she can actively...
The duration of symptoms before diagnosis (lag time) was defined for 184 236 children diagnosed as having a malignancy at the Royal Hospital Sick Children, Edinburgh time period January 1982 until December 1990. natural logarithm lag correlated with age, gender, diagnostic group, white cell count in acute leukaemia, clinical stage disease solid tumours, and event free survival. Age significantly associated time, older presenting later. In groups, mean ranged from 2.8 weeks nephroblastoma to...