A5068695524- Social Sciences and Governance
- French Urban and Social Studies
- Genetic diversity and population structure
- Agriculture and Rural Development Research
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Neuropeptides and Animal Physiology
- Genetic Neurodegenerative Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chemical Synthesis and Analysis
- Hedgehog Signaling Pathway Studies
- Migration, Aging, and Tourism Studies
- Education, sociology, and vocational training
- Cancer-related molecular mechanisms research
- Identification and Quantification in Food
- Aquaculture disease management and microbiota
- Receptor Mechanisms and Signaling
- Epigenetics and DNA Methylation
- Health disparities and outcomes
- Neuroendocrine Tumor Research Advances
- Urban Transport and Accessibility
- Congenital heart defects research
- MicroRNA in disease regulation
- Plant and Fungal Interactions Research
- Genomics and Chromatin Dynamics
McGill Genome Centre
2000-2025
McGill University
1999-2025
Great Lakes Fishery Commission
2021
McGill University and Génome Québec Innovation Centre
2013-2016
University of British Columbia
2012
Centre National pour la Recherche Scientifique et Technique (CNRST)
2002
McGill University Health Centre
2000
Montreal General Hospital
1999
Canadian Forest Service
1996
Centre hospitalier de l'Université Laval
1996
Abstract Sonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers the developing central nervous system. Here, we use unbiased sequencing transcriptome across large cohort 250 tumors to reveal differences among molecular subtypes disease, demonstrate previously unappreciated importance non-coding RNA transcripts. We identify alterations within cAMP dependent pathway ( GNAS , PRKAR1A ) which converge on GLI2 activity show that 18% have genetic event...
The internal transcribed spacer (ITS) of the ribosomal DNA (rDNA) subunit repeat was sequenced in 12 isolates Cylindrocladium floridanum and 11 Cylindrocarpon destructans. Sequences were aligned compared with ITS sequences other fungi GenBank. Some intraspecific variability present within our collections C. destructans but not floridanum. Three variants identified destructans, there no apparent association between host or geographic origin. Two primers synthesized for specific amplification...
Significance Convex lens-induced nanoscale templating (CLINT) represents a conceptual breakthrough in nanofluidic technology for single-molecule manipulation. CLINT solves key challenge faced by the nanofluidics field bridging multiple-length scales required to efficiently bring analytes from pipette tip channel. To do this, loads into embedded nanofeatures via dynamic control of applied vertical confinement, which we have demonstrated loading and extending DNA within nanochannels. offers...
Nontoxic multinodular goiter (MNG) occurs frequently, but its genetic etiology is not well established. Familial MNG and occurring with ovarian Sertoli-Leydig cell tumor are associated germline DICER1 mutations. We recently identified second somatic ribonuclease (RNase) IIIb mutations in two MNGs.The objective of the study was to investigate occurrence mutational clonality MNG.MNGs from 15 patients (10 five without mutations) were selected based on tissue availability.Core biopsies/scrapings...
Brook trout (Salvelinus fontinalis) is a socioeconomically important fish species for fisheries, aquaculture and aquatic conservation. We produced 2.5 Gb reference assembly by combining Hi-C chromosome conformation capture with high-coverage short- long-read sequencing of fully homozygous mitotic gynogenic doubled haploid fish, which facilitates highly complex salmonid genomes. The has an N50 50.98 Mb 88.9% the total assembled sequence length anchored into 42 main chromosomes, 63.44%...
Introduction Many tools support housing decisions for older adults but often overlook mobility patterns and social health. We explored these factors in Canadians living at home to inform decisions. Methods conducted a mixed-methods study with 20 (65+) from Quebec Alberta independently or senior residences outdoor mobility. Data collection included sociodemographic information, GPS tracking, walking interviews, daily journals, in-depth interviews. which physical assets barriers health...
Here, we present an annotated, chromosome-anchored, genome assembly for Lake Trout (Salvelinus namaycush) - a highly diverse salmonid species of notable conservation concern and excellent model research on adaptation speciation. We leveraged Pacific Biosciences long-read sequencing, paired-end Illumina proximity ligation (Hi-C) previously published linkage map to produce contiguous composed 7378 contigs (contig N50 = 1.8 Mb) assigned 4120 scaffolds (scaffold 44.975 Mb). Long read sequencing...
Abstract Despite the commercial importance of Greenland Halibut (Reinhardtius hippoglossoides), important gaps still persist in our knowledge this species, including its reproductive biology and sex determination mechanism. Here, we combined single-molecule sequencing long reads (Pacific Sciences) with chromatin conformation capture (Hi-C) data to assemble first chromosome-level reference genome for species. The high-quality assembly encompassed more than 598 Megabases (Mb) assigned 1594...
We have previously postulated that the binding of human immunodeficiency virus type 1 (HIV-1) to cell surface CD4 induces signal transduction pathways down-modulate production progeny virions in acutely infected T cells (M. Tremblay, S. Meloche, Gratton, M. A. Wainberg, and R.-P. Sékaly, EMBO J. 13:774-783, 1994). To evaluate possibility cross-linking might indeed affect viral gene expression, we introduced a molecular construct made luciferase reporter placed under control regulatory...
Abstract Genetic sexing strains (GSS) are an important tool in support of sterile insect technique (SIT) applications against pests and disease vectors. The yet unknown temperature-sensitive lethal (tsl) gene the recently identified white pupae (wp) have been used as selectable markers most successful GSS developed so far, Ceratitis capitata (medfly) VIENNA 8 GSS. molecular identification tsl may open way for its use a marker development other vectors SIT importance. Prior studies already...
Abstract The opioid receptor (OPR) family comprises the mu-, delta-, and kappa-opioid, nociceptin receptors that belong to superfamily of 7-transmembrane spanning G protein-coupled (GPCRs). mu-opioid is main target for clinically used analgesics, its biology has been extensively studied. N-terminally truncated 6TM isoform produced through alternative splicing OPRM1 gene displays unique signaling analgesic properties, but it unclear if other OPRs have same ability. In this study, we built a...
The present study characterized the surface shear forces induced by sparging for different conditions (i.e.continuous, alternating and pulse) membrane module confi gurations (i.e.spacing).The root mean square (RMS) of gas sparging, which has been reported to be related extent fouling control in systems, were relatively similar continuous, pulse sparging.Considering that uses approximately half volume sparged than continuous or results suggest is best approach.The RMS substantially higher...
<sec> <title>BACKGROUND</title> A variety of tools exist to support decision-making about housing among older adults; however, adults’ mobility patterns and social health have not been adequately considered as pivotal considerations in decisions housing. </sec> <title>OBJECTIVE</title> Examine Canadians living at home inform options. <title>METHODS</title> Using a mixed-methods study, we recruited convenience sample 20 adults Quebec Alberta. Eligibility criteria were: a) aged 65 years or...
Brook trout ( Salvelinus fontinalis ) is a socioeconomically important fish species for fisheries, aquaculture and aquatic conservation. We produced 2.5 Gb reference assembly by combining Hi-C chromosome conformation capture with high-coverage short- long-read sequencing of fully homozygous mitotic gynogenic doubled haploid fish, which facilitates highly complex salmonid genomes. The has N50 50.98 Mb 88.9% the total assembled sequence length anchored into 42 main chromosomes, 63.44%...
Here we present an annotated, chromosome-anchored, genome assembly for Lake Trout (Salvelinus namaycush) – a highly diverse salmonid species of notable conservation concern and excellent model research on adaptation speciation. We leveraged Pacific Biosciences long-read sequencing, paired-end Illumina proximity ligation (Hi-C), previously published linkage map to produce contiguous composed 7,378 contigs (contig N50 = 1.8 mb) assigned 4,120 scaffolds (scaffold 44.975 mb). 84.7% the was 42...