A5051464368- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Esophageal and GI Pathology
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Long-Term Effects of COVID-19
- Asthma and respiratory diseases
- Sulfur Compounds in Biology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 and COVID-19 Research
- Cardiac Arrhythmias and Treatments
- Esophageal Cancer Research and Treatment
- Diabetes and associated disorders
- Mycobacterium research and diagnosis
- Infectious Diseases and Mycology
- Dysphagia Assessment and Management
- Adipose Tissue and Metabolism
- Hemoglobinopathies and Related Disorders
- Immune Cell Function and Interaction
- Infections and bacterial resistance
- Single-cell and spatial transcriptomics
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Fungal Infections and Studies
- Vascular anomalies and interventions
Tohoku University
2017-2025
Tokyo Yamate Medical Center
2022-2024
Japan Community Healthcare Organization
2024
Gifu University
2024
The University of Tokyo
2024
Kanazawa University
2021
Nippon Medical School
2006-2017
Tokyo Metropolitan Tama-Hokubu Medical Center
2013
<b><i>Background:</i></b> Vonoprazan (VPZ) is a novel potassium-competitive acid blocker that may be clinically beneficial for proton pump inhibitor (PPI)-resistant reflux esophagitis (RE). The aim of this study was to investigate the efficacies VPZ therapy at 20 mg 4 weeks in patients with PPI-resistant RE and maintenance 10 8 who have been successfully treated. <b><i>Methods:</i></b> Subjects comprised 24 (Los Angeles classification grade...
Supersulphides are inorganic and organic sulphides with sulphur catenation diverse physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal cysteine persulphide synthase (CPERS). Here, we identify protective of supersulphides in viral airway infections (influenza COVID-19), aged lungs chronic lung diseases, including obstructive pulmonary disease (COPD), idiopathic fibrosis (IPF). We develop method for breath...
Although cases of respiratory bacterial infections associated with coronavirus disease 2019 (COVID-19) have often been reported, their impact on the clinical course remains unclear. Herein, we evaluated and analyzed complication rates infections, causative organisms, patient backgrounds, outcome in Japanese patients COVID-19.We performed a retrospective cohort study that included inpatients COVID-19 from multiple centers participating Japan Taskforce (April 2020 to May 2021) obtained...
Abstract Background Alveolar macrophages are professional phagocytes that remove microbial pathogens inhaled into the lung. The phagocytic ability is compromised in chronic obstructive pulmonary disease (COPD). However, molecular mechanisms underlying this defect phagocytosis not clearly defined. Materials and methods Cell suspensions were collected from lung tissues of patients undergoing resection. detected as FSC hi / SSC /CD45 + /CD206 cells isolated cell suspension by flow-cytometry....
The airway epithelial barrier function is disrupted in the airways of asthmatic patients. Abnormal mitochondrial biogenesis reportedly involved pathogenesis asthma. However, role dysfunction has not been elucidated yet. This study aimed to clarify whether peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC-1α), a central regulator biogenesis, disruption induced by aeroallergens.BEAS-2B cells were exposed house dust mite (HDM) and expressions PGC-1α E-cadherin, junctional...
Abstract Background and Aim: The pathophysiology of non‐erosive reflux disease is poorly understood. Triggering secondary peristalsis impaired in patients with erosive esophagitis but data are lacking. aim this study was to evaluate the difference esophageal motility between healthy subjects. Methods: Twenty disease, symptoms occurring more than twice per week, 20 subjects comparable age sex underwent manometry. Primary tested 10 swallows a 5‐mL water bolus. Secondary triggered by distention...
Alveolar macrophages (AMs) in patients with chronic obstructive pulmonary disease (COPD) orchestrate persistent inflammation the airway. We find that Siglec-1-negative alveolar have a wide range of proinflammatory landscapes and protease-expressing phenotype. Moreover, this subset is associated pathogenesis COPD responds to viral stimuli.
Abstract Immunometabolism regulates functions and fates of immune cells including T cells. Supersulphides, which are universal metabolites containing catenated sulphur atoms, have various physiological based on their unique redox properties. Here we found that activation T-cell receptor (TCR) signalling was accompanied by supersulphide decrease, suggests a regulatory contribution metabolism to function. Consistently, inhibiting synthesis facilitated TCR exacerbated allergen-induced type 2...
Background and Aim: The reason that some reflux episodes evoke symptoms is poorly understood, therefore the aim of this study to assess determinants perception in patients with non-erosive disease (NERD) on proton pump inhibitor (PPI) therapy. Methods: Ten NERD persistent symptoms, despite double-dose PPI therapy, were included study. All had a positive symptom index (SI), which was determined by ambulatory 24-hour combined impedance-pH monitoring. Reflux identified classified as acid,...
Rational Corticosteroid therapy plays a key role in the treatment of COVID-19 patients with respiratory failure. However, rebound phenomenon after steroid cessation rarely occurs. Here, we investigated clinical features therapy. Methods In total, 84 treated corticosteroids were enrolled and analysed retrospectively. A was defined as when patient’s status deteriorated corticosteroid therapy, without secondary bacterial infection. Results Subjects group more likely to having severe failure...
<b><i>Backgrounds:</i></b> It is generally thought that esophageal motility decreases with age; however, a decrease in may also be caused by esophagitis. The aim of this study to investigate the effects aging and acid reflux on motility. <b><i>Methods:</i></b> 40 young (under 45) healthy subjects (HS), elderly (over 65) HS, patients mild esophagitis (RE), underwent high-resolution manometry (HRM). Lower sphincter pressure (LESP), primary...
Various mechanisms have been suggested to be responsible for contributing the occurrence of proton pump inhibitor (PPI)-resistant non-erosive reflux disease (NERD). The aims this study were clarify pathogenesis PPI-resistant NERD.Fifty-three patients with NERD, who had persistent symptoms despite taking double-dose PPI, included in study. After excluding eosinophilic esophagitis (EoE) and primary esophageal motility disorder, impedance-pH monitoring was carried out. In symptom index...
Smoking and chronic obstructive pulmonary disease (COPD) are risk factors for severe COVID-19. However, limited literature exists on the effect of COPD smoking COVID-19 outcomes. This study examined impact exposure in pack-years (PY) outcomes among smokers Japan.The included 1266 enrolled by Japan task force between February 2020 December 2021. PY status was self-reported patients. Patients were classified into non-COPD (n = 1151) 115) groups; group further <10 293), 10-30 497), >30 361)....
Background: A study in Japan has found that nizatidine (NIZ) is more effective than other histamine H2 receptor agonists (H2RAs) treating reflux esophagitis (RE), although the NIZ group included a greater number of patients with severe RE. As there was no difference level acid suppression among H2RAs, it possible effects on esophageal exposure (EAE) besides suppression. In this study, effect transient lower sphincter relaxations (TLESRs) and evaluated healthy subjects. Methods: 10 subjects,...
Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease Rie Tanaka,1 Hisatoshi Sugiura,1 Mitsuhiro Yamada,1 Tomohiro Ichikawa,1 Akira Koarai,1 Naoya Fujino,1 Satoru Yanagisawa,1 Katsuhiro Onodera,1 Tadahisa Numakura,1 Kei Sato,1 Yorihiko Kyogoku,1 Hirohito Sano,1 Shun Yamanaka,1 Tatsuma Okazaki,1 Tsutomu Tamada,1 Motohiko Miura,2 Tsuneyuki Takahashi,3 Masakazu Ichinose1 1Department of Respiratory Medicine, Tohoku University...
The mechanisms that cause acid reflux in patients with non-erosive disease (NERD), including those determine how extends proximally, are not yet clear.Concurrent esophageal manometry and pH monitoring were performed for 3 h after a meal 13 NERD, 12 mild esophagitis (RE), healthy subjects (HS).Transient lower sphincter (LES) relaxation (TLESR) was the major mechanism of all three groups. LES pressure did differ between At 2 cm above LES, there no differences groups number TLESR-related...