Makoto Masuda
A5036723821- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- Respiratory viral infections research
- Diabetes and associated disorders
- Respiratory Support and Mechanisms
- Single-cell and spatial transcriptomics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- interferon and immune responses
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- IL-33, ST2, and ILC Pathways
- Hematological disorders and diagnostics
- Metastasis and carcinoma case studies
- Erythrocyte Function and Pathophysiology
- CRISPR and Genetic Engineering
- Sarcoidosis and Beryllium Toxicity Research
- Genetic Associations and Epidemiology
- Occupational and environmental lung diseases
- Antibiotic Use and Resistance
- Eosinophilic Esophagitis
- Cancer Diagnosis and Treatment
- RNA modifications and cancer
Fujisawa City Hospital
1990-2025
Gunma Chuo Hospital
2023
Keio University
2022
National Institute of Health Sciences
2021
Yokohama City University
2015
We investigated the clinical course of individuals with 2019 novel coronavirus disease (COVID-19) who were transferred from Diamond Princess cruise ship to 12 local hospitals. The conditions and courses patients pneumonia compared those without pneumonia. Among 70 (median age: 67 years) analyzed, major symptoms fever (64.3%), cough (54.3%), general fatigue (24.3%). Forty-three (61.4%) had Higher body temperature, heart rate, respiratory rate as well higher lactate dehydrogenase (LDH),...
Although cases of respiratory bacterial infections associated with coronavirus disease 2019 (COVID-19) have often been reported, their impact on the clinical course remains unclear. Herein, we evaluated and analyzed complication rates infections, causative organisms, patient backgrounds, outcome in Japanese patients COVID-19.We performed a retrospective cohort study that included inpatients COVID-19 from multiple centers participating Japan Taskforce (April 2020 to May 2021) obtained...
Abstract Corticosteroids use in coronavirus disease 2019 (COVID-19) is controversial, especially mild to severe patients who do not require invasive/noninvasive ventilation. Moreover, many factors remain unclear regarding the appropriate of corticosteroids for COVID-19. In this context, multicenter, retrospective, propensity score–matched study was launched evaluate efficacy systemic corticosteroid administration hospitalized with COVID-19 ranging degree severity from critically-ill disease....
Purpose. The predictive factor of response to antituberculous therapy has not been fully elucidated. Airway acidity thought be a potential indicator the bactericidal activity. Therefore, we hypothesized that monitoring airway by measuring sputum pH could predict therapy. Methods. A total 47 patients having newly diagnosed, smear-positive, active pulmonary tuberculosis were enrolled between October 2011 and March 2014. Sputum samples serially analyzed before after treatment. Eligible who...
Among patients with idiopathic pulmonary fibrosis (IPF), few studies have investigated the clinical impact of anti-fibrotic treatment (AFT) and without comorbidities. The aim study was to determine whether Charlson Comorbidity Index score (CCIS) can predict efficacy AFT in IPF.We retrospectively assessed data extracted from medical records IPF who received agents between 2009 2019. collected included age, sex, CCIS, function test, high-resolution computed tomography (HRCT) pattern,...
2019 年12 月に中国湖北省武漢市で発生した新型コロナウイルス感染症は,急激な勢いで世界中へ拡大し,本邦でも明らかな感染経路の特定できない症例が増加している.当院は第二種感染症指定医療機関であり,45 症例のCOVID-19 感染症を経験した.平均年齢は50.6 歳で,男性33 名,女性12 名であった.発熱は39 名86.7%),咳嗽は33 名(73.3%),倦怠感は24 名(53.3%),下痢は5 名(11.1%)で認めた.また,患者増加に伴う医療崩壊を回避するために神奈川県が構築した神奈川モデルにおける重症度分類に当てはめると,軽症30 名,中等症14 名,重症1 名であった.経過中に軽症から中等症へ悪化した症例は1/30 名(3.3%)であり,中等症から重症に悪化した症例は6/14 名(42.9%)であった.軽症は自宅または宿泊施設等での療養,中等症以上は医療機関での入院となるため,患者搬送先を決める上で神奈川モデルにおける重症度分類は,その後の臨床経過を踏まえると妥当な分類であることが示唆された.
Pneumonia is a common disease among the aging population in Japan. Hence, it important to elucidate risks related pneumonia mortality. Since Streptococcus pneumoniae most commonly observed pathogen, pneumococcal vaccination recommended older adults. Therefore, this study aimed clarify clinical features of pneumonia, including status vaccination, hospitalized adult patients Japan.This single-centered retrospective was conducted by reviewing medical records all with acute at Fujisawa City...
Background and Aims: Anti-aquaporin-4 (AQP-4) immunoglobulin G is an autoantibody marker that often observed in patients with neuromyelitis optica spectrum disorder (NMOSD), inflammatory of the central nervous system.Currently, involvement anti-AQP4-IgG pathogenesis lung diseases remains unknown.We report clinical histological characteristics pulmonary anti-AQP-4 antibody-positive NMOSD.Methods: We conducted a retrospective review medical records 63 NMOSD, immunohistochemistry on biopsy...
In the current study, we examined synergistic effect of IL-17A and TNF-α to contraction airway smooth muscle cells its mechanism.In muscles assay, 12hrs incubation both with 10 ng/ml increased ASM contractility synergistically.In western blot, expressions RhoA Rock2 which are key proteins were when treated TNF-α.Then, performed qRT-PCR for mRNA Rock2.The levels 12 hrs.We speculated TNF-a synergistically stabilized confirmed that T-half extended two cytokines 1hr.This study indicates enhance...
In the current study, we examined synergistic effect of IL-17A and TNF-α to contraction airway smooth muscle cells its mechanism.In muscles assay, 12hrs incubation both with 10 ng/ml increased ASM contractility synergistically.In western blot, expressions RhoA Rock2 which are key proteins were when treated TNF-α.Then, performed qRT-PCR for mRNA Rock2.The levels 12 hrs.We speculated TNF-a synergistically stabilized confirmed that T-half extended two cytokines 1hr.This study indicates enhance...