A5038162416- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Emergency and Acute Care Studies
- Respiratory Support and Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Inhalation and Respiratory Drug Delivery
- Mycobacterium research and diagnosis
- Long-Term Effects of COVID-19
- Lung Cancer Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Antimicrobial Resistance in Staphylococcus
- Extraction and Separation Processes
- Tracheal and airway disorders
- Recycling and Waste Management Techniques
- Respiratory viral infections research
- Immune Response and Inflammation
- Respiratory and Cough-Related Research
- Enterobacteriaceae and Cronobacter Research
Nagoya University
2016-2025
National Taiwan University Hospital
2021
Merck (Germany)
2021
Polyphor (Switzerland)
2021
Yale University
2021
Pfizer (United Kingdom)
2021
Shionogi (Japan)
2021
American Thoracic Society
2021
GlaxoSmithKline (Brazil)
2021
Roche (Switzerland)
2021
Rationale: Identification of patients with drug-resistant pathogens at initial diagnosis is essential for treatment pneumonia.Objectives: To elucidate clinical features community-acquired pneumonia (CAP) and healthcare-associated (HCAP), to clarify risk factors in CAP HCAP.Methods: A prospective observational study was conducted hospitalized 10 institutions Japan. Pathogens identified as not susceptible ceftriaxone, ampicillin-sulbactam, macrolides, respiratory fluoroquinolones were defined...
Shigeru Kohno, Yoshifumi Imamura, Yuichiro Shindo, Masafumi Seki, Tadashi Ishida, Shinji Teramoto, Junichi Kadota, Kazunori Tomono, Akira Watanabe Unit of Molecular Microbiology and Immunology, Nagasaki University, Graduate School Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501 Japan Institute for Advanced Research, Nagoya Department Respiratory Medicine, Division Infection Control Prevention, Osaka University Hospital, Kurashiki Central Hitachinaka Medical Education Research Center,...
Despite appropriate therapy, Candida bloodstream infections are associated with a mortality rate of approximately 40%. In animal models, impaired immunity due to T cell exhaustion has been implicated in fungal sepsis mortality. The purpose this study was determine potential mechanisms fungal-induced immunosuppression via immunophenotyping circulating lymphocytes from patients microbiologically documented infections.Patients blood cultures positive for any species were studied. Non-septic...
Klebsiella pneumoniae is a common cause of sepsis and particularly associated with healthcare-associated infections. New strategies are needed to prevent or treat infections due the emergence multi-drug resistant K. pneumoniae. The goal this study was determine global diversity distribution O (lipopolysaccharide) K (capsular polysaccharide) antigens on large (>500) collection strains isolated from blood inform vaccine development efforts. A total 645 isolates were collected patients...
Abstract Background Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide range of acute and chronic infections frequently associated with healthcare-associated infections. Because its ability to rapidly acquire resistance antibiotics, P. are difficult treat. Alternative strategies, such as vaccine, needed prevent . We collected total 413 isolates from the blood cerebrospinal fluid patients 10 countries located on 4 continents during 2005–2017 characterized these inform...
ABSTRACT Background and Aims Interactions between the lung microbiome pulmonary epithelium plays a pivotal role in shaping immunity lung. Idiopathic fibrosis (IPF) is most common interstitial disease (ILD). Some patients with IPF develop episodic acute exacerbations often associated microbial dysbiosis lungs. This study aimed to investigate etiologic agents as well ILDs sarcoidosis. Methods analyzed 31 divided into (IPF‐stable, n = 12), exacerbation of (AE‐ILDs, 6), sarcoidosis ( 13) groups....
The initial assessment of the severity community-acquired pneumonia (CAP) is important for patient management. Japanese Respiratory Society (JRS) has proposed a 6-point scale (0-5) to assess clinical CAP. A-DROP scoring system assesses following parameters: (i) Age (male >or= 70 years, female 75 years); (ii) Dehydration (blood urea nitrogen (BUN) 210 mg/L); (iii) failure (SaO(2) <or= 90% or PaO(2) 60 mm Hg); (iv) Orientation disturbance (confusion); and (v) low blood Pressure (systolic...
The number of patients with non-HIV Pneumocystis pneumonia (PCP) is increasing widespread immunosuppressive treatment. We investigated the clinical characteristics PCP and its association microbiological genotypes.Between January 2005 March 2010, all in 2 university hospitals who had been diagnosed by PCR were enrolled this study. Retrospective chart review patients, genotypes, 30-day mortality examined.Of 82 adult investigated, 50 (61%) inflammatory diseases, 17 (21%) solid malignancies, 12...
Sepsis remains a major cause of morbidity and mortality in most intensive care units. Protracted sepsis can evolve into state profound immunosuppression characterized by secondary infections, frequently with opportunistic-type pathogens. Immunoadjuvant therapy is currently being evaluated as novel treatment for patients sepsis. Two the promising immunoadjuvants are interleukin-7 (IL-7) anti-programmed cell death 1 antibody (anti-PD-1). Both IL-7 anti-PD-1 have been reported to boost host...
Patients with protracted sepsis develop impaired immunity, which predisposes them to acquiring secondary infections. One of the most common and lethal infections is Pseudomonas aeruginosa pneumonia. Immunoadjuvant therapy a promising approach reverse sepsis-induced immunosuppression improve morbidity mortality from Interleukin-7 an immunoadjuvant that improves survival in clinically relevant animal models polymicrobial peritonitis fungal sepsis. This study investigated effect recombinant...
ABSTRACT Some important virulence factors have been elucidated in Klebsiella pneumoniae infections. We investigated the relationship between and multilocus sequence types (STs) assessed risk for bacteremia patients with pneumonia due to K. . From April 2004 through 2012, a total of 120 isolates from (23 97 without bacteremia) were collected 10 medical institutions Japan. Additionally, strains serotype K2 that isolated >30 years ago included this study. These characterized using typing...
Pneumonia causes a significant burden of disease worldwide. Although all populations are at risk pneumonia, those extremes age and with immunosuppressive disorders, underlying respiratory disease, critical illness particularly vulnerable. clinical practice guidelines addressing the management treatment pneumonia exist, few supporting studies focus on crucial contributions host in pathogenesis recovery. Such essential considerations include factors that lead to susceptibility lung infections;...
Background: Prescribing antiviral agents for severe acute respiratory syndrome coronavirus 2 requires careful consideration based on the patient’s risk factors disease progression and their vaccination status. However, effective interventions ensuring appropriate use of by physicians have yet to be fully established. Thus, this study evaluated impact an educational film prescription rates 2019 (COVID-19). Methods: This prospective, nationwide, web-based survey enrolled 1500 physicians. They...
We report a 24‐year‐old male patient with sarcoidosis who developed subcutaneous nodules on his thighs and buttocks at the sites of repeated intramuscular injections. Histologically, there were extensive areas caseation necrosis surrounded by typical sarcoidal granuloma. The regressed spontaneously over period 4 months, concurrently, both bilateral hilar adenopathy results immunological tests, returned to normal. think that these lesions scar tissue induced frequent injections in childhood....