A5051877443- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Escherichia coli research studies
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Neonatal and Maternal Infections
- Vector-borne infectious diseases
- Bacteriophages and microbial interactions
- Hepatitis Viruses Studies and Epidemiology
- Viral Infections and Vectors
- Immune Response and Inflammation
- Cancer Research and Treatments
- T-cell and B-cell Immunology
- Bacterial biofilms and quorum sensing
- Immune Cell Function and Interaction
- Vibrio bacteria research studies
- Bacterial Genetics and Biotechnology
- Carbohydrate Chemistry and Synthesis
- Mosquito-borne diseases and control
- Global Cancer Incidence and Screening
- Burn Injury Management and Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Thyroid Cancer Diagnosis and Treatment
- Vector-Borne Animal Diseases
Pfizer (United States)
2021-2025
University of Maryland, Baltimore
2015-2024
Centre international de recherche sur le cancer
2021-2023
Pfizer (China)
2022
Pfizer (France)
2022
University of Mary
2021
University of Baltimore
2012-2019
University of California, Santa Barbara
2007-2008
Natural history studies have correlated serotype-specific anti-capsular polysaccharide (CPS) IgG in newborns with a reduced risk of group B streptococcal disease. A hexavalent CPS-cross-reactive material 197 glycoconjugate vaccine (GBS6) is being developed as maternal to prevent invasive streptococcus young infants.
ABSTRACT Nontyphoidal Salmonella enterica serovars Enteritidis and Typhimurium are a common cause of gastroenteritis but also invasive infections enteric fever in certain hosts (young children sub-Saharan Africa, the elderly, immunocompromised individuals). O polysaccharides (OPS) flagellar proteins virulence factors protective antigens. The surface poorly immunogenic do not confer immunologic memory, limitations overcome by covalently attaching them to carrier proteins. We conjugated core...
Klebsiella pneumoniae is a common cause of sepsis and particularly associated with healthcare-associated infections. New strategies are needed to prevent or treat infections due the emergence multi-drug resistant K. pneumoniae. The goal this study was determine global diversity distribution O (lipopolysaccharide) K (capsular polysaccharide) antigens on large (>500) collection strains isolated from blood inform vaccine development efforts. A total 645 isolates were collected patients...
Among more than 2500 nontyphoidal Salmonella enterica (NTS) serovars, S. serovar Typhimurium and Enteritidis account for approximately fifty percent of all human isolates NTS reported globally. The global incidence gastroenteritis in 2010 was estimated to be 93 million cases, 80 which were contracted via food-borne transmission. It is that 155,000 deaths resulted from 2010. also causes severe, extra-intestinal, invasive bacteremia, referred as (iNTS) disease. iNTS disease usually presents a...
Abstract Background Pseudomonas aeruginosa is an opportunistic pathogen that causes a wide range of acute and chronic infections frequently associated with healthcare-associated infections. Because its ability to rapidly acquire resistance antibiotics, P. are difficult treat. Alternative strategies, such as vaccine, needed prevent . We collected total 413 isolates from the blood cerebrospinal fluid patients 10 countries located on 4 continents during 2005–2017 characterized these inform...
ABSTRACT While nontyphoidal Salmonella (NTS) has long been recognized as a cause of self-limited gastroenteritis, it is becoming increasingly evident that multiple-antibiotic-resistant strains are also emerging important causes invasive bacteremia and focal infections, resulting in hospitalizations deaths. We have constructed attenuated enterica serovar Typhimurium Enteritidis can serve live oral vaccines “reagent strains” for subunit vaccine production safe economical manner. Prototype CVD...
Klebsiella pneumoniae (KP) and Pseudomonas aeruginosa (PA) are important human pathogens that associated with a range of infection types, including wound disseminated infections. Treatment has been complicated by rising rates antimicrobial resistance. Immunoprophylactic strategies not constrained resistance mechanisms. Vaccines against these organisms would be public health tools, yet they available. KP surface O polysaccharides (OPS) protective antigens in animal models infection....
ABSTRACT Enteric fever caused by Salmonella enterica serovar Paratyphi A infection has emerged as an important public health problem. Recognizing that in randomized controlled field trials oral immunization with attenuated S. Typhi live vaccine Ty21a conferred significant cross-protection against S . B but not disease, we undertook a clinical study to ascertain whether humoral immune responses could explain the trial results. of adult residents Maryland elicited predominantly IgA...
ABSTRACT Invasive Salmonella infections for which improved or new vaccines are being developed include enteric fever caused by enterica serovars Typhi, Paratyphi A, and B sepsis meningitis in young children sub-Saharan Africa nontyphoidal (NTS) serovars, particularly S. Typhimurium Enteritidis. Assays needed to measure functional antibodies elicited the assess their immunogenicities potential protective capacities. We vitro assays quantify serum bactericidal antibody (SBA) activity induced S...
ABSTRACT To address the problem of increased antimicrobial resistance, we developed a glycoconjugate vaccine comprised O-polysaccharides (OPS) four most prevalent serotypes Klebsiella pneumoniae (KP) linked to recombinant flagellin types A and B (rFlaA rFlaB) Pseudomonas aeruginosa (PA). Flagellin is major subunit flagellar filament. Flagella B, essential virulence factors for PA, are glycosylated with different glycans. We previously reported that while both rFlaA rFlaB were highly...
Background Antibiotic-resistant Salmonella enterica serovar Paratyphi A, the agent of paratyphoid A fever, poses an emerging public health dilemma in endemic areas Asia and among travelers, as there is no licensed vaccine. Integral to our efforts develop a S. vaccine, we addressed role flagella potential protective antigen by comparing cell-associated with exported flagellin subunits expressed attenuated strains. Methodology strain ATCC 9150 was first deleted for chromosomal guaBA locus,...
Non-typhoidal Salmonella (NTS) serovars S. Enteritidis and Typhimurium are a major cause of invasive bacterial disease (e.g., bacteremia, meningitis) in infants young children sub-Saharan Africa also occasionally highly susceptible hosts (young infants, the elderly, immunocompromised subjects) industrialized countries. No licensed vaccines exist against human NTS infections. core O polysaccharide (COPS) FliC (Phase 1 flagellin subunits) each constitute protective antigens murine models. COPS...
Invasive infections associated with non-typhoidal Salmonella (NTS) serovars Enteritidis (SE), Typhimurium (STm) and monophasic variant 1,4,[5],12:i:- are a major health problem in infants young children sub-Saharan Africa, currently, there no approved human NTS vaccines. O-polysaccharides flagellin proteins protective antigens animal models of invasive infection. Conjugates SE core O-polysaccharide (COPS) chemically linked to have enhanced the anti-COPS immune response protected mice against...
Salmonella enterica serovars Typhi and Paratyphi (S. Paratyphi) A B cause enteric fever in humans. Of the paratyphoid group, S. is most common serovar. In 2000, there were an estimated 5.4 million cases of worldwide. More recently has accounted for increasing fraction all fever. Although vaccines typhoid have been developed use decades, not yet licensed. Several vaccines, however, are development based on either whole cell live-attenuated strains or repeating units lipopolysaccharide...
Abstract To better understand the conformational properties of glycan shield covering surface HIV gp120/gp41 envelope (Env) trimer, and how impacts accessibility underlying protein surface, we performed enhanced sampling molecular dynamics (MD) simulations a model glycosylated Env related systems. Our simulation studies revealed conformationally heterogeneous with network glycan-glycan interactions more extensive than those observed to date. We found that partial preorganization glycans...
Maturation of antibody responses entails somatic hypermutation (SHM), class-switch DNA recombination (CSR), plasma cell differentiation, and generation memory B cells, it is thought to require T help. We showed that Toll-like receptor 4 (TLR4)–B (BCR) (receptor for antigen) coengagement by 4-hydroxy-3-nitrophenyl acetyl (NP)–lipopolysaccharide (LPS) ( Escherichia coli lipid A polysaccharide O-antigen) or TLR5-BCR Salmonella flagellin induces mature NP in Tcr β −/− δ NSG/B mice. TLR-BCR...
Abstract Background Lyme borreliosis (LB) is the most common tick-borne disease in US, with approximately 476,000 cases diagnosed and treated annually nearly 90 million individuals living high incidence jurisdictions. Vector-focused prevention measures have varying levels of effectiveness due to low utilization, poor adherence, or cost. A safe efficacious vaccine prevent LB warranted. We provide an update on Pfizer-Valneva VLA15 clinical development program, specifically safety...