A5013648540- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Semantic Web and Ontologies
- Antibiotic Resistance in Bacteria
- Neonatal and Maternal Infections
- Tuberculosis Research and Epidemiology
- Probabilistic and Robust Engineering Design
- Salmonella and Campylobacter epidemiology
- Electronic Health Records Systems
- Biomedical Text Mining and Ontologies
- Autism Spectrum Disorder Research
- SARS-CoV-2 and COVID-19 Research
- Data Management and Algorithms
- Antimicrobial Resistance in Staphylococcus
- Infections and bacterial resistance
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- Genomics and Rare Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Clostridium difficile and Clostridium perfringens research
- Advanced Database Systems and Queries
- Sepsis Diagnosis and Treatment
- Vibrio bacteria research studies
- Bacterial Identification and Susceptibility Testing
- Pneumocystis jirovecii pneumonia detection and treatment
University of Pretoria
2014-2025
National Health Laboratory Service
2018-2025
Abdelmalek Essaâdi University
2018-2024
Université Paris Cité
2004-2023
Hôpital Necker-Enfants Malades
2003-2023
Assistance Publique – Hôpitaux de Paris
2005-2023
October University of Modern Sciences and Arts
2019-2023
University of Sciences and Technology Houari Boumediene
2020-2023
Centre Hospitalier de Versailles
2023
Inserm
2023
Natural history studies have correlated serotype-specific anti-capsular polysaccharide (CPS) IgG in newborns with a reduced risk of group B streptococcal disease. A hexavalent CPS-cross-reactive material 197 glycoconjugate vaccine (GBS6) is being developed as maternal to prevent invasive streptococcus young infants.
Background Coagulase-negative staphylococci, mainly Staphylococcus epidermidis, are the most frequent cause of late-onset sepsis (LOS) in neonatal intensive care unit (NICU) setting. However, recent reports indicate that methicillin-resistant, vancomycin-heteroresistant capitis could emerge as a significant pathogen NICU. We investigated prevalence, clonality and vancomycin susceptibility S. isolated from blood NICU infants compared these data to adult patients. Methodology/Principal...
Abstract Background We assessed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA shedding duration and magnitude among persons living with human immunodeficiency virus (HIV, PLHIV). Methods From May through December 2020, we conducted a prospective cohort study at 20 hospitals in South Africa. Adults hospitalized symptomatic disease 2019 (COVID-19) were enrolled followed every days nasopharyngeal/oropharyngeal (NP/OP) swabs until documentation of cessation SARS-CoV-2 (2...
Background The World Health Organization (WHO) recommends systematic symptom screening for tuberculosis (TB). However, TB prevalence surveys suggest that this strategy does not identify millions of patients, globally. Undiagnosed or delayed diagnosis contribute to transmission and exacerbate morbidity mortality. We conducted a cluster-randomized trial large urban rural primary healthcare clinics in 3 provinces South Africa evaluate whether novel intervention targeted universal testing (TUTT)...
Sepsis and septic shock are key contributors to mortality in critically ill patients thus prompt recognition management thereof is central achieving improved patient outcomes. Early initiation of appropriate antimicrobial therapy constitutes a crucial component the strategy early identification causative pathogen essential informing therapeutic choices. The BioFire FilmArray blood culture (BCID) panel US Food Drug Administration (FDA) approved rapid, multiplex polymerase chain reaction assay...
Amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) are devastating neurodegenerative diseases involving the progressive degeneration of neurons. No cure is available for patients diagnosed with these diseases. A prominent feature both ALS PD accumulation protein inclusions in cytoplasm degenerating neurons; however, particular proteins constituting vary: RNA-binding TDP-43 FUS most notable ALS, while α-synuclein aggregates into Lewy bodies PD. In diseases, genetic causes fail...
Abstract Background Ralstonia species are Gram-negative bacilli of low virulence. These organisms capable causing healthcare associated infections through contaminated solutions. In this study, we aimed to determine the source mannitolilytica bacteraemia in affected patients a haemodialysis unit. Methods Our laboratory noted an increase cases caused by mannitililytica between May and June 2016. All underwent at unit academic hospital. The reverse osmosis filter water system was found be...
Background An outbreak of multidrug-resistant Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloacae infections in a neonatal ward within tertiary hospital South Africa resulted the mortality 10 patients six months. In this work, genomic epidemiology molecular factors mediating were investigated. Methods Bacterial cultures obtained from clinical samples collected infected neonates underwent phenotypic analyses to determine their species, sensitivity antibiotics, production...
Abstract Klebsiella pneumoniae (KPn) colonizes multiple anatomical sites and is a leading cause of invasive disease death in African children; however, there no comparative genomic analysis between colonizing strains. This study investigated the relatedness KPn isolates South infants; evaluated relative invasiveness based on sequence types (ST), capsular (KL), lipopolysaccharide (O) loci by calculating case-carrier ratios (CCRs). There was less diversity amongst (22 ST, 17 K-loci) than (31...
Background. Chronic kidney disease (CKD) is renal dysfunction lead to fail in body's ability maintain metabolic, fluid electrolyte, and balance. It mostly results uremia or azotemia can be classified into stages 1 5 based on the deterioration of glomerular filtration rate (GFR. These complications deficiency erythropoietin (EPO) possible iron loss patients hemodialysis are considered main factors contributing anemia CKD patients. Aimes: This study aims evaluate prevalence aged 18 years...
Rare diseases cover a group of conditions characterized by low prevalence, affecting less than 1 in 2,000 people; 5000 to 7000 rare have been currently identified Europe. Most do not any curative treatment. They represent thus an important public health concern. CEMARA is based on n-tier architecture. Its main objective collect continuous and complete records patients with diseases, their follow-up through web-based Information System, analyse the epidemiological patterns. In France, 41 out...
Abstract Background Non-typhoidal salmonellae (NTS) have been associated with invasive disease, notably meningitis, in immunocompromised individuals. Infections of this nature carry high rates morbidity and mortality. Colistin resistance is a rare finding, more so an isolate such as cerebrospinal fluid (CSF). has important infection control implications failure to manage phenomenon may lead the loss our last line defence against multi-drug resistant Gram-negative organisms. To knowledge,...
We aimed to provide an analysis of A. baumannii complex (ABC) isolated from blood cultures in South Africa.ABC surveillance was conducted 1 April 2017 30 September 2019 at 19 hospital sites any age and sex. Organism identification performed using the MALDI-TOF MS antimicrobial susceptibility testing (AST), MicroScan Walkaway System. confirmed colistin resistance with Sensititre, FRCOL panel, selected for whole-genome sequencing.During study period, we identified 4822 cases ABC, which 2152...
Methodological approaches based on the nonlocal beam theory, differential quadrature and internal random coefficients methods are elaborated for parameters uncertainty effects dynamic behavior of viscoelastic Carbon NanoTubes (CNT) conveying viscous fluid. The general polynomial chaos superposition principle used several that may follow various distribution laws considered. A selecting procedure most influencing CNT is given. space multimodal time domains formulated frequency responses...
In the present study, sera of 56 children suffering from visceral Mediterranean leishmaniasis were analysed. The incidence circulating immune complexes (CIC) by ELISA technique using conglutinin binding assay was 39% before treatment, 28% after first and nil at end second one. C4 levels remain low even treatment. anti-leishmania antibodies (AAL) account for 95% cases treatment 84% rheumatoid factor (FR) also remains with more or less same frequency (74%) search a correlation between presence...
Patients' end-stage renal disease (ESRD) characteristics are changing. Improving the quality of care requires a steady adaptation treatment modalities together with equity access to dialysis facilities. We explored ability health system cope demand ESRD care. An analysis 5-year follow-up cohort patients in Limousin region, France, was performed. Data were entered Multi-Source Information System Renal Epidemiology and Network (REIN). The participation rate centres complete. analysed patient...