A5006677486- Lipid metabolism and biosynthesis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Magnetic properties of thin films
- Magnetic Properties of Alloys
- Photosynthetic Processes and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Rare-earth and actinide compounds
- Magnetic Properties and Applications
- Immune Response and Inflammation
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Plant biochemistry and biosynthesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Algal biology and biofuel production
- Congenital Diaphragmatic Hernia Studies
- Sulfur Compounds in Biology
- Metallic Glasses and Amorphous Alloys
- Respiratory viral infections research
- IL-33, ST2, and ILC Pathways
- Antibiotic Resistance in Bacteria
- Plant nutrient uptake and metabolism
Tohoku University
2016-2025
St. Marianna University School of Medicine
2025
Graduate School USA
2023
Japan Medical Association
2023
Kanazawa University
2006-2021
Nihon University
2021
Tokai University
1991-2020
Saitama International Medical Center
2016
University of Fukui
2016
Lung Institute
2014
Abstract Tissue repair often occurs in organs damaged by an inflammatory response. Inflammatory stimuli induce a rapid and massive release of cells including neutrophils from the bone marrow. Recently, many studies suggested that marrow have potential to differentiate into variety cell types. However, whether marrow-derived progenitor (BMPCs), or how much impact suppression BMPCs has on injured organ is not clear. Here we show LPS, component Gram-negative bacterial walls, lung airways,...
<h3>Rationale</h3> The influence of COPD exacerbation on the endothelium is not completely understood. Circulating endothelial microparticles (EMPs) are membrane vesicles in circulating blood that shed by activated or apoptotic cells. <h3>Objective</h3> To compare EMP numbers stable patients with those during and after exacerbation. <h3>Methods</h3> We examined 80 patients, 27 exacerbated COPD, 20 healthy non-COPD volunteers. EMPs were defined as CD144+ MPs (VE-cadherin EMPs), CD31+/CD41−...
Idiopathic pulmonary fibrosis (IPF) is a disease with poor prognosis. Although the median survival 3 years, clinical course varies to large extent among IPF patients. To date, there has been no definitive prognostic marker. Extracellular vesicles (EVs) are known hold nucleic acid, including microRNAs, and regulate gene expression in recipient cells. Moreover, EVs have shown express distinct surface proteins or enveloped microRNAs depending on parent cell pathological condition. We aimed...
Abstract Background The excess and persistent accumulation of fibroblasts due to aberrant tissue repair results in fibrotic diseases such as idiopathic pulmonary fibrosis. Recent reports have revealed significant changes microRNAs during fibrosis evidence support a role for myofibroblast differentiation the epithelial-mesenchymal transition context It has been reported that microRNA-21 is up-regulated myofibroblasts promotes transforming growth factor-beta signaling by inhibiting Smad7....
Supersulphides are inorganic and organic sulphides with sulphur catenation diverse physiological functions. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal cysteine persulphide synthase (CPERS). Here, we identify protective of supersulphides in viral airway infections (influenza COVID-19), aged lungs chronic lung diseases, including obstructive pulmonary disease (COPD), idiopathic fibrosis (IPF). We develop method for breath...
Despite standard treatment with systemic corticosteroids and/or antifungal triazoles, a substantial proportion of patients allergic bronchopulmonary aspergillosis (ABPA) experience frequent relapses and require long-term despite unfavorable adverse effects. We investigated the efficacy safety anti-interleukin (IL)-5/IL-5 receptor α chain (Rα) monoclonal antibodies (mAbs) in ABPA complicated by asthma. cases treated anti-IL-5/IL-5Rα mAbs were collected from 132 medical institutes 2018...
<b>Background:</b> Tissue repair often occurs in organs damaged by various inflammatory diseases including pneumonia. Inflammatory stimuli induce a rapid and massive release of cells from the bone marrow. Recent studies have suggested that marrow potential to differentiate into variety cell types. It has been shown administration lipopolysaccharide (LPS) murine lungs induces endothelial progenitor (EPCs) circulation, derived EPCs contribute lung after injury mice. This study was undertaken...
Neutrophils are usually the first circulating leukocytes to respond during bacterial pneumonia. Their expression of oxidants, proteases, and other mediators present in granules is well documented, but their ability produce through transcription translation after migration an inflammatory site has been appreciated only more recently. Interferon (IFN)-γ a cytokine with many functions important host defense immunity.To examine function IFN-γ pneumonias.IFN-γ mRNA protein were measured digests...
Bacterial pneumonia is a common public health problem associated with significant mortality, morbidity, and cost. Neutrophils are usually the earliest leukocytes to respond bacteria in lungs. rapidly sequester pulmonary microvasculature migrate into lung parenchyma alveolar spaces, where they perform numerous effector functions for host defense. Previous studies showed that migrated neutrophils produce IFN-γ early during induced by Streptococcus pneumoniae production of regulates bacterial...
Oxidative stress is a major aetiological factor driving chronic obstructive pulmonary disease (COPD). Recently recognised as potent antioxidants, reactive persulfide and polysulfide species are biosynthesised by cystathionine β-synthase γ-lyase. The production of in the lungs patients with COPD remain unknown.The aim this study was to examine persulfides polysulfides, such glutathione (GSSH), cysteine (CysSSH) trisulfide (GSSSH), lung-resident cells epithelial lining fluid (ELF) obtained...
The subcellular localization and several biochemical activities of nonspecific lipid transfer protein (nsLTP) were investigated. A section a castor bean cotyledon cell was labeled with anti-nsLTP serum followed by A-gold. Gold particles more abundant in the glyoxysome matrix vessel wall than other areas. Cell fractionation analysis 6-day-old cotyledons sucrose density gradient centrifugation demonstrated that 13% nsLTP distributed glyoxysomal fraction, identified on basis catalase as marker,...
Thiolactomycin, an antibiotic with the structure of (4S)-(2E,5E)-2,4,6-trimethyl-3-hydroxy-2,5,7-octatriene-4-++ +thiolide, selectively inhibits type II fatty acid synthases. The mode thiolactomycin action on synthase system Escherichia coli was investigated. Of six individual enzymes system, [acyl-carrier-protein] (ACP) acetyltransferase and 3-oxoacyl-ACP were inhibited by thiolactomycin. On other hand, not affected this antibiotic. inhibition reversible. As to ACP acetyltransferase,...
When the upper leaf surface of spinach (Spinacia oleracea L.) plants was treated with [1-(14)C]acetate and grown for 2 days, (14)C effectively incorporated into acyl moieties lipids in ratios approximately their composition by mass. Fumigation ozone (0.5 microliter per liter) caused a redistribution among lipid classes, i.e. marked increase content triacylglycerol (TG) 1,2-diacylglycerol (1,2-DG) decrease label monogalactosyldiacylglycerol (MGDG) without affecting distribution fatty acids....
The amino acid sequence of two nonspecific lipid‐transfer proteins (nsLTP) B and C from germinated castor bean seeds have been determined. Both the consist 92 residues, as for nsLTP previously reported, their calculated M r values are 9847 9593 nsLTP‐B nsLTP‐C, respectively. sequences compared to known nsLTP‐A same source, 68% 35% similar, No variation was found at positions cysteine indicating that they might be involved in disulfide bridges.
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Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, and its possible involvement in pathophysiology of COPD viral-induced exacerbations has been demonstrated. IL-33 shown be increased airway epithelial cells from patients, but regulating mechanism expression remains largely unknown. In current study, we examined whether oxidative stress, which participates pathogenesis COPD, affects also evaluated effect during viral infection. The stress IL-33, signal pathway was after...
Molecular species and fatty acid distribution of triacylglycerol (TG) accumulated in spinach (Spinacia oleracea L.) leaves fumigated with ozone (0.5 microliter per liter) were compared those monogalactosyldiacylglycerol (MGDG). Analysis positional the acids MGDG TG by enzymatic digestion method showed that hexadecatrienoate (16:3) was restricted to sn-2 position glycerol backbone both TG, whereas alpha-linolenate (18:3) preferentially located at sn-1 MGDG, and/or sn-3 positions suggesting...