A5004864001- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Enterobacteriaceae and Cronobacter Research
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Pharmaceutical and Antibiotic Environmental Impacts
- Respiratory viral infections research
- Vibrio bacteria research studies
- Bacterial Infections and Vaccines
- Bacterial biofilms and quorum sensing
- Infective Endocarditis Diagnosis and Management
- Antimicrobial Resistance in Staphylococcus
- Mycobacterium research and diagnosis
- Ear Surgery and Otitis Media
- Infections and bacterial resistance
- Antibiotics Pharmacokinetics and Efficacy
- Otolaryngology and Infectious Diseases
- SARS-CoV-2 and COVID-19 Research
- Respiratory and Cough-Related Research
- Antibiotic Use and Resistance
- SARS-CoV-2 detection and testing
- Viral gastroenteritis research and epidemiology
- Infectious Diseases and Tuberculosis
- Salmonella and Campylobacter epidemiology
- Bacillus and Francisella bacterial research
Nara Medical University
2016-2025
Nara Medical University Hospital
2022
Nara Prefecture General Medical Center
2022
National Archives and Records Administration
2022
Japan Society of Chemotherapy
2020
Kitasato University
1998-2020
Shandong Academy of Agricultural Sciences
2018
Osaka Ekisaikai Hospital
2018
Tohoku University
2005-2016
Kawagoe Technical High School
2016
Photocatalysts are promising materials for solid-state antiviral coatings to protect against the spread of pandemic coronavirus disease (COVID-19). This paper reports that copper oxide nanoclusters grafted with titanium dioxide (CuxO/TiO2) inactivated severe acute respiratory syndrome 2 (SARS-CoV-2) virus, including its Delta variant, even under dark condition, and further it illumination a white fluorescent bulb. To investigate inactivation mechanism, denaturation spike proteins SARS-CoV-2...
ABSTRACT In 1996, Serratia marcescens KU3838 was isolated from the urine of a patient with urinary tract infection at hospital in northern Japan and found to contain plasmid pKU501. Previously, we determined that pKU501 carries bla IMP genes for TEM-1-type β-lactamases as well producing both types (H. Yano, A. Kuga, K. Irinoda, R. Okamoto, T. Kobayashi, M. Inoue, J. Antibiot. 52:1135–1139, 1999). pKU502 is recombinant contains 1.5-kb DNA fragment, including metallo-β-lactamase gene, obtained...
The evidence of association between sexually transmitted infection and prostatic inflammation in human prostate cancer (PCa) is limited. Here, we sought to examine the potential with inflammatory environment carcinogenesis. We screened surgical biopsy specimens from 45 patients PCa against a panel infection-related organisms using polymerase chain reaction examined severity intraprostatic by pathologic examination. Among tested organisms, rate Mycoplasma genitalium (Mg) was significantly...
This study aimed to evaluate the prevalence and genetic characteristics of carbapenemase-producing Enterobacteriaceae (CPE) in hospital sewage river water Philippines, which has a typical tropical maritime climate. We collected 83 samples from 7 10 sites. CPE were identified using CHROMagar mSuperCARBA, Gram-negative strains matrix-assisted laser desorption ionization-time flight mass spectrometry (MALDI-TOF MS) or 16S rRNA gene sequencing. Resistance genes PCR DNA sequencing,...
Objective"Clinical Practice Guidelines for the Diagnosis and Management of Acute Otitis Media in Children—2018 update (2018 Guidelines)" aim to provide appropriate recommendations about diagnosis management children with acute otitis media (AOM), including recurrent (recurrent AOM), under 15 years age. These evidence-based were created consensus subcommittee members, taking into consideration unique characteristics bacteriology antimicrobial susceptibilities AOM pathogens Japan, as well...
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread across the world. Inactivating virus in saliva and oral cavity represents a reasonable approach to prevent human-to-human transmission because is easily transmitted through routes dispersed saliva. Persimmon-derived tannin condensed type of that strong antioxidant antimicrobial activity. In this study, we investigated antiviral effects persimmon-derived...
Trans-tympanic insertion of a new silicone plug seems to be useful for controlling the distressing symptoms patients with chronic patulous Eustachian tube (PET).To evaluate effectiveness blocking isthmus PET in whose were resistant other therapies > 6 months.The (total length 23-25 mm; tip diameter 1.0-2.0 mm) was inserted 44 ears 37 PET. It through tympanic orifice ET obstruct via an incision anterosuperior portion membrane.Insertion possible all except two ears, which it failed because...
(1-3)-β-D-glucan (BDG) is a cell-wall polysaccharide component found in most fungi. The measurement of BDG useful diagnostic marker for invasive fungal infections. However, it well known that interfering substances can result false positive reactions. We encountered patient who underwent lung transplantation and presented with highly elevated values, despite having no evidence infection. therefore hypothesized values were originated from the gauze products used during surgery. While contain...
Carbapenems serve as a last resort for the clinical treatment of multidrug-resistant infections. Therefore, rapid spread carbapenemase-producing strains represents serious public health threat, further limiting antibiotic choices. The current findings hypervirulent Klebsiella pneumoniae isolates in Japan demonstrate potential broad and transfer these genes, necessitating close surveillance.
ABSTRACT To investigate how bacterial pathogens spread from child to in a day care center, we monitored six children, two boys and four girls, born between August 1995 November 1997, attending center analyzed nasopharyngeal samples them using pulsed-field gel electrophoresis (PFGE). We obtained cultures all of the affected children almost unaffected September 1998 March 1999 after some presented simultaneously with purulent rhinorrhea. Moreover, when was found have acute otitis media,...
Acinetobacter baumannii presents a clinical challenge when it is non-susceptible to carbapenems. The prevalence of carbapenem-non-susceptible A. in Japan unclear, as previous studies have been limited scope. We investigated the spread and performed comparison with findings from overseas. A total 305 non-duplicate isolates spp. 176 medical facilities all geographical regions were tested for susceptibility antimicrobial agents by agar dilution method. Isolates MICs imipenem ≥4 mg/L underwent...
The prevalence of ESBL has been increasing worldwide. In this study, we investigated the molecular characteristics among clinical isolates Escherichia coli from a Japanese tertiary hospital. A total 71 consecutive and nonduplicate ESBL-positive E. collected at Tohoku University Hospital between January 2008 March 2011 were studied. antimicrobial susceptibility profile these strains was determined. PCR sequencing performed to identify genes for β-lactamase (bla(TEM), bla(SHV),...
Extended-spectrum β-lactamases (ESBLs) have become a problem among AmpC-producing Enterobacteriaceae and the emergence of concomitant quinolone resistance in β-lactamase-producing isolates poses global threat. In this study we investigated prevalence regional variation ESBLs Japanese clinical Citrobacter spp. analysed plasmid-mediated (PMQR) determinants ESBL-producing spp.A total 348 collected throughout Japan were studied. Screening boronic acid disc test performed to detect with...
Coughing plays an important role in influenza transmission; however, there is insufficient information regarding the viral load cough because of lack convenient and reliable collection methods. We developed a portable airborne particle-collection system to measure load; it equipped with air sampler draw pass through gelatin membrane filter connected cone-shaped, megaphone-like device guide airflow membrane. The was dissolved medium, measured using quantitative real-time reverse...
Objectives To identify risk factors and clinical outcomes in patients with bacteremia due to extended-spectrum beta-lactamase (ESBL) or carbapenemase-producing Escherichia coli, as well determine the prevalence genetic background of such isolates. Methods Case control study was performed E. coli between January 2008 May 2013 (n = 115) at a tertiary university hospital Japan. Cases had ESBL-producing (ESBL-EC) whereas controls non-ESBL-producing (non-ESBL-EC) A retrospective chart review...
Two cerium molybdates (Ce2Mo3O12 and γ-Ce2Mo3O13) were prepared using either polymerizable complex method or hydrothermal process. The obtained powders almost single-phase with different valence. Both samples found to have antiviral activity against bacteriophage Φ6. Especially, γ-Ce2Mo3O13 exhibited high both Φ6 SARS-CoV-2 coronavirus, which causes COVID-19. A synergetic effect of Ce molybdate ion was inferred along the specific surface area as key factors for activity.
Stutzerimonas is a recently proposed genus comprising strains formerly classified as Pseudomonas stutzeri. The includes at least 16 identified species. nitrititolerans, previously known was initially isolated from bioreactor. Only one case of human infection has been reported to date, and its pathogenicity remains unknown. We present community-acquired S. nitrititolerans bacteremia in 77-year-old Japanese man with sacral pressure ulcer. On admission for cerebral infarction, empirical...