A5020560255- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- Infection Control in Healthcare
- Antimicrobial Resistance in Staphylococcus
- COVID-19 Clinical Research Studies
- Streptococcal Infections and Treatments
- Infection Control and Ventilation
- Clostridium difficile and Clostridium perfringens research
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 detection and testing
- Microscopic Colitis
- COVID-19 and Mental Health
- Data-Driven Disease Surveillance
- Disaster Response and Management
- Antifungal resistance and susceptibility
- Pneumonia and Respiratory Infections
- Infective Endocarditis Diagnosis and Management
- Long-Term Effects of COVID-19
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- Antibiotic Use and Resistance
- Enterobacteriaceae and Cronobacter Research
- Misinformation and Its Impacts
St. Marianna University School of Medicine
2015-2025
Japan Society of Chemotherapy
2025
Tohoku University
2006-2019
Kawasaki Municipal Hospital
2015-2017
Osaka Prefectural Government
2013
Tohoku University Hospital
2008-2011
VA Maryland Health Care System
2011
Okayama Prefecture
2011
Yokohama City Seibu Hospital
2007
Hy-Line (United States)
2005
Identifying and understanding reasons for being unsure or unwilling regarding intention to be vaccinated against coronavirus disease (COVID-19) may help inform future public health messages aimed at increasing vaccination coverage. We analyzed a broad array of individual's psychological dispositions with regard decision-making about COVID-19 in Japan.A nationally representative cross-sectional web survey was conducted 30053 Japanese adults aged 20 years older the end February 2021. In...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of disease 2019 (COVID-19), is an enveloped, single-stranded RNA virus. Favipiravir orally administrable antiviral drug whose mechanism action to selectively inhibit RNA-dependent polymerase. A preliminary trial in COVID-19 patients reported significant improvements across a multitude clinical parameters, but these findings have not been confirmed adequate well-controlled trial. We conducted randomized, single-blind,...
Coronavirus disease 2019 (COVID-19) is spreading worldwide; there a need to address its sequelae known as Long COVID. This study evaluated postvaccination changes in symptoms and antibody titers patients with Patients visiting the outpatient department specializing COVID at our hospital were enrolled. Changes before 14-21 days after first vaccination. Antibody measured using ARCHITECT SARS-CoV-2 IgG II Quant same time. included 42 (median age: 45 years; 17 [40.5%] men). Median pre- 456...
Trust in governments and public institutions as a determinant of health outcomes has gained increased attention since the COVID-19 pandemic. Provided historically low confidence vaccines Japan, investigating role trust information sources actual vaccination uptake behavior will be invaluable for future vaccine promotion policymaking. Therefore, objective this study was to elucidate determinants evaluate relationship between different Japan. For study, we leveraged longitudinal series...
We previously reported an outbreak in a neurosurgery ward of catheter-associated urinary tract infection with multidrug-resistant (MDR) Pseudomonas aeruginosa strain IMCJ2.S1, carrying the 6'-N-aminoglycoside acetyltransferase gene [aac(6')-Iae]. For further epidemiologic studies, 214 clinical isolates MDR P. showing resistance to imipenem (MIC >or= 16 microg/ml), amikacin 64 and ciprofloxacin 4 microg/ml) were collected from 13 hospitals same prefecture Japan. also 70 that sensitive one or...
In the absence of widespread testing, symptomatic monitoring efforts may allow for understanding epidemiological situation spread coronavirus disease 2019 (COVID-19) in Japan. We obtained data from a social networking service (SNS) messaging application that monitors self-reported COVID-19 related symptoms real time Fukuoka Prefecture, aimed at not only prefecture, but also highlighting usefulness approaches rely on self-reporting using SNS during pandemic, and informing assessment Japan's...
Background: The World Health Organization declared the novel coronavirus outbreak (COVID-19) to be a pandemic on March 11, 2020. Large-scale monitoring for capturing current epidemiological situation of COVID-19 in Japan would improve preparation and prevention massive outbreak.
Toxigenic culture and cytotoxicity assays are standard tests for detecting C. difficile infection (CDI). Others include immunochromatographic strips, a rapid diagnostic test that detects glutamate dehydrogenase (GDH toxins simultaneously, the nucleic acid amplification (NAAT) toxin-producing genes. NAAT may not be available in some facilities, so 2-step method can adopted where GDH-positive toxin-negative specimens selected first, then toxigenic is performed these specimens. The testing...
Abstract Background Cross-neutralizing capacity of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is important in mitigating (re-)exposures. Role antibody maturation, the process whereby selection higher affinity augments host immunity, to determine SARS-CoV-2 neutralizing was investigated. Methods Sera from convalescents at 2, 6, or 10 months postrecovery, and BNT162b2 vaccine recipients 3 25 weeks postvaccination, were analyzed. Anti-spike IgG...
(1-3)-β-D-glucan (BDG) is a cell-wall polysaccharide component found in most fungi. The measurement of BDG useful diagnostic marker for invasive fungal infections. However, it well known that interfering substances can result false positive reactions. We encountered patient who underwent lung transplantation and presented with highly elevated values, despite having no evidence infection. therefore hypothesized values were originated from the gauze products used during surgery. While contain...
On April 7, 2020, the Japanese government declared a state of emergency regarding novel coronavirus (COVID-19). Given nation-wide spread in major cities and rapid increase number cases with untraceable infection routes, large-scale monitoring for capturing current epidemiological situation COVID-19 Japan is urgently required.A chatbot-based healthcare system named COOPERA (COvid-19: Operation Personalized Empowerment to Render smart prevention And AN care seeking) was developed surveil...
Understanding COVID-19 risk perception may help inform public health messaging aimed at encouraging preventive measures and improving countermeasures against the pandemic. We conducted an online survey of 29,708 Japanese adults in February 2021 estimated associations between a broad array individual factors. Two logistic regressions were constructed to estimate factors associated with (defined as responding that one might become infected within next 6 months), severe illness among those who...
Acinetobacter baumannii presents a clinical challenge when it is non-susceptible to carbapenems. The prevalence of carbapenem-non-susceptible A. in Japan unclear, as previous studies have been limited scope. We investigated the spread and performed comparison with findings from overseas. A total 305 non-duplicate isolates spp. 176 medical facilities all geographical regions were tested for susceptibility antimicrobial agents by agar dilution method. Isolates MICs imipenem ≥4 mg/L underwent...
The prevalence of ESBL has been increasing worldwide. In this study, we investigated the molecular characteristics among clinical isolates Escherichia coli from a Japanese tertiary hospital. A total 71 consecutive and nonduplicate ESBL-positive E. collected at Tohoku University Hospital between January 2008 March 2011 were studied. antimicrobial susceptibility profile these strains was determined. PCR sequencing performed to identify genes for β-lactamase (bla(TEM), bla(SHV),...
Extended-spectrum β-lactamases (ESBLs) have become a problem among AmpC-producing Enterobacteriaceae and the emergence of concomitant quinolone resistance in β-lactamase-producing isolates poses global threat. In this study we investigated prevalence regional variation ESBLs Japanese clinical Citrobacter spp. analysed plasmid-mediated (PMQR) determinants ESBL-producing spp.A total 348 collected throughout Japan were studied. Screening boronic acid disc test performed to detect with...
We investigated whether reduced lymphocyte count, could predict the development of severe COVID-19. also examined ciclesonide prevent COVID-19 among patients with predictors. This was a retrospective cohort study. Of 30 included patients, 12, 14, and 4 were allocated to pneumonia, non-severe non-pneumonia groups, respectively. The group low level counts sixth day after onset significantly intubated approximately three days later. incidence pneumoniae requiring intubation are lower in treated...
The mechanism of allergic reactions to COVID-19 mRNA vaccines has not been clarified. Polyethylene glycol (PEG) is a potential antigen in the components vaccines. However, there little evidence that allergy after vaccination related PEG. Furthermore, role polysorbate (PS) as an also objective this study was investigate whether PEG and PS allergies are reasonable causes symptoms by detecting PEG-specific PS-specific antibodies.
Antifungal agents are not always efficient in resolving vulvovaginal candidiasis (VVC), a common genital infection caused by the overgrowth of Candida spp., including albicans, or preventing recurrent infections. Although lactobacilli (which dominant microorganisms constituting healthy human vaginal microbiota) important barriers against VVC, Lactobacillus metabolite concentration needed to suppress VVC is unknown.We quantitatively evaluated concentrations determine their effect on 27...