A5031265107- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Long-Term Effects of COVID-19
- Cardiomyopathy and Myosin Studies
- COVID-19 epidemiological studies
- Trypanosoma species research and implications
- Immunotherapy and Immune Responses
- Protein Tyrosine Phosphatases
- Animal Virus Infections Studies
- Congenital heart defects research
- Cardiac Ischemia and Reperfusion
- COVID-19 and healthcare impacts
- Mosquito-borne diseases and control
- Malaria Research and Control
- Cardiac Fibrosis and Remodeling
- COVID-19 and Mental Health
- Heart Rate Variability and Autonomic Control
- RNA modifications and cancer
- Viral gastroenteritis research and epidemiology
- Cardiac Structural Anomalies and Repair
- Respiratory Support and Mechanisms
- Influenza Virus Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- CAR-T cell therapy research
Osaka Metropolitan University
2022-2025
University School
2024
Yokohama City University
2019-2024
St. Marianna University School of Medicine
2024
Louisiana State University Health Sciences Center Shreveport
2024
Metropolitan University
2023
Tokyo Metropolitan University
2022-2023
Osaka International University
2023
Osaka City University
2019-2022
The University of Tokyo
2012-2021
Abstract The fibrogenic response in tissue-resident fibroblasts is determined by the balance between activation and repression signals from tissue microenvironment. While molecular pathways which transforming growth factor-1 (TGF-β1) activates pro-fibrogenic mechanisms have been extensively studied are recognized critical during fibrosis development, factors regulating TGF-β1 signaling poorly understood. Here we show that macrophage hypoxia suppresses excessive a heart via oncostatin-m (OSM)...
Past SARS-CoV-2 infection is an important determinant of protection from reinfection and postvaccine immune responses. Our results show that different immunoassays, by design, harbor variable capability tracking under waning antibody concentrations.
Abstract Background Adults infected with Plasmodium spp. in endemic areas need to be re-evaluated light of global malaria elimination goals. They potentially undermine interventions but remain an overlooked aspect public health strategies. Methods This study aimed estimate the prevalence infections, identify underlying parasite species, and assess predicting factors among adults residing area from Democratic Republic Congo (DRC). A community-based cross-sectional survey subjects aged 18...
Abstract Background Cross-neutralizing capacity of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is important in mitigating (re-)exposures. Role antibody maturation, the process whereby selection higher affinity augments host immunity, to determine SARS-CoV-2 neutralizing was investigated. Methods Sera from convalescents at 2, 6, or 10 months postrecovery, and BNT162b2 vaccine recipients 3 25 weeks postvaccination, were analyzed. Anti-spike IgG...
We used 2 commercially available antibody tests to estimate seroprevalence of severe acute respiratory syndrome coronavirus infection in Japan during June 2020. Of 7,950 samples, 8 were positive by both assays. Using reliable conjunction is an effective method for estimating low prevalence settings.
Establishing vaccine-based population immunity has been the key factor in attaining herd protection. Thanks to expedited worldwide research efforts, potency of mRNA vaccines against coronavirus disease 2019 (COVID-19) is now incontestable.
Abstract To evaluate the antibody response following initial four doses of mRNA vaccines (BNT162b2 or mRNA-1273) in SARS-CoV-2-naïve healthy adults and investigate factors influencing titer increases, this prospective cohort study was conducted Japan from March 2021. The included participants who received either 1st 2nd (n = 467), 3rd dose 157), 4th 89). Blood samples were collected before up to 6 months after each dose, anti-receptor-binding domain levels measured. Multivariate analysis...
Abstract Recently, immune response to coronavirus disease (COVID-19) has attracted attention where an association between higher antibody titer and worsening severity been reported. However, our experiences with severe COVID-19 patients low titers led hypothesizing that suppressed humoral may be associated poorer prognosis in COVID19. In this study, COVID19 were measured at 7, 10, 12, 14 days after onset. Patients divided into survivors non-survivors. SARS-CoV-2 IgM non-survivors 0.06 AU...
Aim Elderly adults are at higher risk for severe COVID‐19 infection. This multicenter, prospective cohort study assessed immunogenicity after vaccinations in elderly residents compared with staff geriatric intermediate care facilities. Predictors of lower antibody titers were also examined. Methods Fifty‐four and 117 who had received three doses the mRNA vaccine between March 2021 September 2022 included. Anti‐receptor binding domain measured 3–4 weeks 6 months vaccinations. Adjusted...
Although several assays are used to measure anti-receptor-binding domain (RBD) antibodies induced after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination, the not fully comparable in practice. This study evaluated immunogenicity of BNT162b2 mRNA vaccine healthy adults using two immunoassays. prospective cohort included SARS-CoV-2-naïve adults, predominantly healthcare workers, aged 20–64 years, who received doses between March and May 2021. Blood samples were collected...
Evidence to guide rescue therapy in refractory Kawasaki disease (KD) is lacking. The aim of this study was determine the most important variables predicting non-response KD.We retrospectively analyzed 171 patients diagnosed with KD resistant initial i.v. immunoglobulin (IVIG). Participants received consisting IVIG monotherapy or plus prednisolone. Characteristics and laboratory were compared between non-responders responders. Multivariate logistic regression analysis performed independent...
We describe the results of testing health care workers, from a tertiary hospital in Japan that had experienced coronavirus disease 2019 (COVID-19) outbreak during first peak pandemic, for severe acute respiratory syndrome 2 (SARS-CoV-2)-specific antibody seroconversion. Using two chemiluminescent immunoassays and confirmatory surrogate virus neutralization test, serological revealed surprising 42% overlooked COVID-19 diagnoses (27/64 cases) occurred when case detection relied solely on...
Two SARS-COV-2 XBB sub-variants, FL.1 and GE.1, have been increasing in prevalence worldwide, but limited information is available about their ability to evade the immune system. GE.1 possess additional mutations located spike RBD compared XBB.1.5, raising concerns of increased neutralization escape. In this study, we assessed neutralizing eleven FDA-approved monoclonal antibody combinations against different omicron variants, including BA.2.75, BA.2.76, BA.4/5, CH.1.1. Among antibodies,...
Aims: Cell–cell interactions between hepatocytes and other liver cells are key to maintaining homeostasis. Cytoglobin (CYGB), expressed exclusively by hepatic stellate (HSC), is essential in mitigating mitochondrial oxidative stress. CYGB absence causes hepatocyte (Hep) dysfunction evokes hepatocarcinogenesis through an elusive mechanism. deficiency speculated hinder nitric oxide dioxygenase (NOD) activity, resulting the elevated formation release of NO. Hence, we hypothesized that NO...
Concomitant heart failure is associated with poor clinical outcome in dialysis patients. The arteriovenous shunt, created as vascular access for hemodialysis, increases ventricular volume-overload, predisposing patients to developing cardiac dysfunction. integral function of mitochondrial respiration critically important the cope hemodynamic overload. involvement, however, activity or reactive oxygen species (ROS) pathogenesis ventricular-overload-induced has not been fully elucidated. We...
The gold standard for coronavirus disease (COVID-19) diagnosis has been the detection of severe acute respiratory syndrome 2 (SARS-CoV-2) RNA by nucleic acid amplification testing (NAAT). On other hand, serological COVID-19 may offer advantages in detecting possibly overlooked infections NAAT.To evaluate seroconversion NAAT-negative pneumonia patients, immunoglobulin M (IgM) and IgG targeting spike protein SARS-CoV-2 were semiquantified an immunofluorescence assay. Seroconversion was...
Coronavirus disease 2019 (COVID-19) sequelae, also known as long COVID, can present with various symptoms. Among these symptoms, autonomic dysregulation, particularly postural orthostatic tachycardia syndrome (POTS), should be evaluated. However, previous studies on the treatment of POTS complicated by COVID-19 are lacking. Therefore, this study aimed to investigate course COVID POTS.
Variants in the LZTR1 (leucine-zipper-like transcription regulator 1) gene (OMIM #600574) have been reported recessive Noonan syndrome patients. In vivo evidence from animal models to support its causative role is lacking.By CRISPR-Cas9 genome editing, we generated lztr1-mutated zebrafish (Danio rerio). Analyses of histopathology and downstream signaling were performed investigate pathogenesis cardiac extracardiac abnormalities syndrome.A frameshift deletion allele was created lztr1. Crosses...
Sepiapterin reductase deficiency (SRD), an extremely rare but treatable neurotransmitter disease, is enzyme defect in the final step of tetrahydrobiopterin (BH4) synthesis.1 Unlike other forms BH4-deficient dopa-responsive dystonia, SRD uniquely does not manifest hyperphenylalaninemia and thus slips through detection by newborn screening. Owing to its variable presenting features need for a sensitive method CSF analysis, diagnosis may be compromised mild phenotypes.2