A5035358691- Respiratory viral infections research
- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Viral gastroenteritis research and epidemiology
- Vector-borne infectious diseases
- Escherichia coli research studies
- Viral Infections and Vectors
- Microbial infections and disease research
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- Enterobacteriaceae and Cronobacter Research
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Virology and Viral Diseases
- COVID-19 epidemiological studies
- Streptococcal Infections and Treatments
- Viral Infections and Immunology Research
- Antimicrobial Resistance in Staphylococcus
- Legionella and Acanthamoeba research
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Infections and Vaccines
- Hepatitis Viruses Studies and Epidemiology
- Bacteriophages and microbial interactions
Yamagata Prefectural Institute of Public Health
2016-2025
National Institute of Infectious Diseases
2023
Nagasaki University
2017
Hokkaido University
2000
Escherichia albertii is a recently recognized close relative of coli . This emerging enteropathogen possesses type III secretion system (T3SS) encoded by the locus enterocyte effacement, similar to enteropathogenic and enterohemorrhagic E. (EPEC EHEC). Shiga toxin-producing strains have also been identified. The genomic features , particularly differences from other species, not yet well clarified. Here, we sequenced genome 29 (3 complete 26 draft sequences) isolated multiple sources...
Abstract Spotted fever group (SFG) rickettsiae are obligate intracellular Gram-negative bacteria mainly associated with ticks. In Japan, several hundred cases of Japanese spotted fever, caused by Rickettsia japonica , reported annually. Other species also known to exist in ixodid ticks; however, their phylogenetic position and pathogenic potential poorly understood. We conducted a nationwide cross-sectional survey on questing ticks understand the overall diversity SFG Japan. Out 2,189...
The incidence of modified measles (M-Me), characterized by milder symptoms than those typical (T-Me), has been increasing in Japan. However, the outbreak dominated M-Me cases not thoroughly investigated worldwide. largest importation-related with genotype D8 occurred Yamagata Prefecture, Japan, from March to April 2017. This phenomenon was observed after Japan had achieved elimination 2015. We confirmed 60 detecting genome virus (MeV). Among cases, 38 were and 22 T-Me. Thirty-nine (65.0%)...
Abstract In many countries with low to moderate tuberculosis (TB) incidence, cases have shifted elderly persons. It is unclear, however, whether these are associated recent Mycobacterium transmission or represent reactivation of past disease. During 2009–2015, we performed a population-based TB investigation in Yamagata Prefecture, Japan, using in-depth contact tracing and 24-loci variable-number tandem-repeat typing optimized for Beijing family M. strains. We analyzed 494 strains, which 387...
Oz virus (OZV) was isolated from an Amblyomma tick in Japan and shown to cause lethal viral myocarditis humans. However, the natural reservoirs distribution of OZV remain unknown. We describe epidemiologic studies conducted by using serum samples collected mammals throughout Japan. The results showed that 27.5% wild boars, 56.1% Sika deer, 19.6% Japanese macaques, 51.0% Asian black bears were positive for virus-neutralizing antibodies against OZV. Approximately 2.8% dogs 1.0% cats also...
Hepatitis E virus (HEV) is a zoonotic pathogen with multiple hosts, posing significant public health risks, especially in regions like Japan where game meat consumption prevalent. This study investigated HEV infection and viral shedding wild boars, sika deer, Japanese serows across Japan. A total of 1896 serum samples were tested for anti-HEV antibodies, 1034 RNA, 473 fecal shedding. Anti-HEV antibodies detected boars from all seven prefectures studied, while RNA was Fukuoka, Oita, Miyazaki...
Abstract Regional disparities in the incidence of tuberculosis (TB) pose several challenges to effective TB control. This study aimed investigate such Osaka City, Japan, by analyzing relationship between and residents’ socioeconomic indicators. Using 42 indicators from 2010 population census, city was clustered into 15 social areas through a factor analysis, during 2012–2016 compared across 4,852 cases. Two geographically adjacent (Area D O) exhibited significantly higher rates, each with...
A survey of antibodies to bovine immunodeficiency virus (BIV) known as lentivirus and leukemia (BLV) was conducted with samples from water buffalo cattle populations in Pakistan. total 370 buffaloes 76 were tested, 10.3% 15.8%, respectively, found positive for anti-BIV p26 determined by Western blotting, while 0.8% no anti-BLV immunodiffusion test. BIV-seropositive have BIV proviral DNA the peripheral blood mononuclear cells nested polymerase chain reaction. This is first report infections buffaloes.
We detected a community outbreak of macrolide-resistant Mycoplasma pneumoniae infection that occurred predominantly among students at 2 schools in Yamagata, Japan.Throat swab specimens were collected from patients who clinically suspected to have M. after testing negative for influenza virus by nasopharyngeal rapid antigen test. performed cultures pneumoniae, and all isolates sequenced the presence mutation 23S rRNA gene.Of 96 between July 2009 January 2010, 83 attending junior high school A...
Abstract We aimed to verify the effectiveness of real-time reverse transcription (rRT) polymerase chain reaction (PCR) for detecting cases modified measles (M-Me) and predicting super-spreader candidates through experience a outbreak dominated by M-Me in Yamagata, Japan, during March–April 2017. applied rRT-PCR specimens from 35 M-Me, nine typical (T-Me) prodromal stage T-Me (P-Me). From among cases, peripheral blood mononuclear cells (PBMC) showed highest positive rate (80.0%), followed...
The incidence of streptococcal toxic shock syndrome (STSS) due to group B Streptococcus (GBS) has been increasing annually in Japan and is becoming a serious challenge. Furthermore, recent years, penicillin- or clindamycin-resistant strains used treating have reported. However, no report analyzed >100 isolates causing syndrome. Therefore, we aimed perform serotyping antimicrobial susceptibility testing 268 isolated from cases involving nonpregnant adult patients between 2014 2021. most...
Climate change, by its influence on the ecology of vectors might affect occurrence vector-borne diseases. This study examines effects meteorological factors in Japan scrub typhus, a mite-borne zoonosis caused Orientia tsutsugamushi. Using negative binomial regression, we analysed relationships between (including temperature, rainfall, snowfall) and spring-early summer cases typhus Yamagata Prefecture, Japan, during 1984-2014. The average temperature July August previous year, cumulative...
Multiple-locus variable-number tandem-repeat analysis (MLVA) typing was performed for Mycoplasma pneumoniae strains isolated between 2004 and 2014 in Yamagata, Japan. The results were examined by considering the combination of P1 type prevalence macrolide resistance-associated mutations. Four-locus (Mpn13-16) MLVA classified 347 into 9 types, including 3 major types: 3-5-6-2, 4-5-7-2, 4-5-7-3. All 3-5-6-2 (77 strains) 2 variants (2a or 2c), while types 4-5-7-2 (181 4-5-7-3 (75 1. circulated...
To determine the timing of emergence macrolide-resistant mutations after macrolide treatment in individuals with Mycoplasma pneumoniae infections.Between October 2011 and December 2013, serial pharyngeal swab specimens were collected before from 21 otherwise healthy children infected M. without mutations. The copy numbers a gene proportion clones showing macrolide-resistance determined for each specimen.After (10-15 mg kg-1 day-1 clarithromycin 5-10 days or 10 azithromycin 3 days), fever...
In this paper, we examine 2 case reports for different reptile-related Salmonella enterica subspecies serotypes. 1, a 5-year-old boy presented with gastroenteritis caused by S. serovar Poona. The suspected source of infection was turtle kept at the patient's home. 2, 4-year-old Abony. Pulsed-field gel electrophoresis analysis suggested that tortoise home infection. This paper presents review literature and an examination cases regarding turtle-associated salmonellosis in Japan.
山形県で2004 年から2013 年の10 年間に分離されたMycoplasma pneumoniae 358 株を対象として，マクロライド系抗菌薬（以下，マクロライド）耐性遺伝子変異およびp1 遺伝子型解析を実施した． その結果，M. にマクロライド耐性をもたらす23S リボゾーマルRNA（以下，rRNA）ドメインVの点変異を6種類検出した（A2063G 変異81 株，A2063T 変異43 株，A2063C 変異1 株，A2064C 株，C2617G 変異4 株およびC2617A 株）．変異株は2008 年以前には2 株のみであったが，2009 年はA2063T 変異を多く検出し，2010 年以降はA2063G 変異が増加した．2009 年以降の年間の変異検出率は20.4％（2011 年）から76.4％（2009 年）の間で推移した． また，本県で分離されたM. のp1 遺伝子型は，1型（278株）および3種類の2型亜種（2a 型〈10 株〉，2b 型〈5 株〉および2c 型〈65 株〉）に分けられた．2012 年以前は1 型菌が多く，年間の1...
To clarify the spread of Mycoplasma pneumoniae infections in semi-closed settings such as schools and family homes using molecular typing methods.We retrospectively searched for school- family-based clusters M. based on information regarding patients from whom strains had been isolated between 2011 2013 Yamagata, Japan. The profile, including P1 type four-locus (Mpn13, 14, 15 16) multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) type, was obtained our previous study.We...
The appropriate choice of antibiotics against Mycoplasma pneumoniae infection has become difficult, as the prevalence macrolide-resistant M. increased.Throat swab specimens were collected from children with clinically suspected while visiting an outpatient clinic. Cultures for done, and all isolates sequenced presence a mutation in 23S rRNA.Of 80 between February 2012 March 2013, 27 (34%) positive on culture. Macrolide-resistant was detected 24 (89%): 23 had A2063G transition, one C2617G...
To identify the vector species for Shimokoshi type Orientia tsutsugamushi, a survey of larval trombiculid mites was conducted in Yamagata Prefecture, Japan from April to May 2012. In all, 2889 were obtained 21 Apodemus speciosus rodent hosts, 2600 which morphologically classified into eight three genera. After screening O. tsutsugamushi DNA individual using real-time PCR targeting 16S ribosomal RNA gene, serotype-specific nested PCRs 56 kDa protein gene performed, followed by sequencing...
Corynebacterium ulcerans is attracting attention as an emerging zoonosis that causes lymphadenitis, dermatitis and respiratory infections. We report here what appears to be the first case of subcutaneous abscess formation in upper extremity due toxigenic C. Japan. Awareness fact can cause a subcutaneous, elastic-hard, less-mobile mass with heat, redness pain extremities important for differential diagnosis.
Sir, Mycoplasma pneumoniae is a common cause of upper and lower respiratory tract infections, especially in children young adults. M. infections can be treated with macrolides, which are generally considered to the first-choice antibiotics for children. However, prevalence macrolide-resistant has gradually increased worldwide reached rate 90% China. In Japan, it been reported that isolates 65.5% 2010 89.5% 2011. resistance macrolides caused by point mutations domain V 23S rRNA gene interfere...