A5072564891- Dermatology and Skin Diseases
- Dermatologic Treatments and Research
- Surgical Sutures and Adhesives
- Connexins and lens biology
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Lymphatic System and Diseases
- melanin and skin pigmentation
- Photodynamic Therapy Research Studies
- Vaccine Coverage and Hesitancy
- Acne and Rosacea Treatments and Effects
- Neonatal and Maternal Infections
- Hair Growth and Disorders
- Zoonotic diseases and public health
- Wound Healing and Treatments
- RNA regulation and disease
- Iron Metabolism and Disorders
- Immune Response and Inflammation
- Trace Elements in Health
- Barrier Structure and Function Studies
- Contact Dermatitis and Allergies
- Angiogenesis and VEGF in Cancer
- Pressure Ulcer Prevention and Management
- Virology and Viral Diseases
- Advanced machining processes and optimization
International Drug Development
2023
Maruho (Japan)
2018-2023
Kyoto Research Park
2020-2021
Toyama City Hospital
2020
Aisin (United States)
2020
The incidence of streptococcal toxic shock syndrome (STSS) due to group B Streptococcus (GBS) has been increasing annually in Japan and is becoming a serious challenge. Furthermore, recent years, penicillin- or clindamycin-resistant strains used treating have reported. However, no report analyzed >100 isolates causing syndrome. Therefore, we aimed perform serotyping antimicrobial susceptibility testing 268 isolated from cases involving nonpregnant adult patients between 2014 2021. most...
Abstract Ozenoxacin is a topical quinolone showing potent antimicrobial activities against Gram-negative and Gram-positive bacteria widely used for the treatment of inflammatory acne. However, anti-inflammatory ozenoxacin have not been examined so far. In present study, we investigated in vitro vivo effects ozenoxacin. The production interleukin (IL)-6 IL-8 by human epidermal keratinocytes stimulated heat-killed Cutibacterium acnes was significantly inhibited at concentrations from 1 to 30...
Tight junctions (TJs) play important roles in epidermal barrier function and their dysfunction is involved the pathogenesis of various skin diseases, including atopic dermatitis (AD). Mucopolysaccharide polysulphate (MPS) active ingredient a moisturizing agent used to treat xerosis patients with AD; however, its mechanism action on TJ remains unclear. To elucidate effects MPS TJs, adult human keratinocyte (HEKa) cells were exposed MPS, subjected Western blotting quantitative PCR analyses for...
BackgroundMucopolysaccharide polysulfate (MPS) is a heparinoid and MPS-containing formulations are widely used as moisturizers for dry skin to treat peripheral vascular insufficiency. Although MPS has therapeutic effects in diseases with microvascular abnormalities, the of on function remain incompletely understood.ObjectiveThe aim this study was evaluate functional activities human pericytes (HPC) dermal endothelial cells (HDMEC) vitro, permeability skin.MethodsThe protein expression...
C3H/HeJ mouse models progress gradually in hair loss from acute to chronic phase and reflect the symptoms of patients with alopecia areata (AA). However, underlying pathological characteristics alteration associated disease progression autoantigens remain unclear.We aimed at elucidating differences between chronic-AA model.We analyzed populations PBMCs, skin-draining lymph node (SDLN) cells, cutaneous cells AA mice using flow cytometry. The cytokine chemokine expressions serum skin were...
The long-term use of topical corticosteroids (TCS) is associated with side effects such as skin atrophy and barrier deterioration. Moisturizers, mucopolysaccharide polysulfate (MPS), have been reported to prevent relapses in atopic dermatitis (AD) when used combination TCS. However, the mechanisms underlying positive MPS TCS AD are poorly understood. In present study, we investigated clobetasol 17-propionate (CP) on tight junction (TJ) function human epidermal keratinocytes (HEKa) 3D...
When selecting external medicines for the treatment of skin diseases, it is thought to be very important consider differences in characteristics their bases, because bases may influence clinical efficacy medicines. In this study, we investigated whether three kinds white petrolatum, macrogol ointment, and aqueous gel affect wound healing. vitro moisture permeability tests demonstrated that these have different coatability water retentivity, with rank order intensity as petrolatum>macrogol...