A5101512949- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Pituitary Gland Disorders and Treatments
- Organ Transplantation Techniques and Outcomes
- Intestinal and Peritoneal Adhesions
- Colorectal and Anal Carcinomas
- Gastroesophageal reflux and treatments
- Adrenal and Paraganglionic Tumors
- Hernia repair and management
- Radiomics and Machine Learning in Medical Imaging
- Pancreatitis Pathology and Treatment
- Surgical Sutures and Adhesives
- Pressure Ulcer Prevention and Management
- COVID-19 diagnosis using AI
- Pediatric Hepatobiliary Diseases and Treatments
- Infectious Disease Case Reports and Treatments
First Affiliated Hospital of Wenzhou Medical University
2007-2021
Wenzhou Medical University
2009-2021
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020-2021
Medical University of Vienna
2009
First Affiliated Hospital Zhejiang University
2009
General Department of Preventive Medicine
2008
Liver cirrhosis is one of the major consequences hepatitis B virus (HBV) infection, and transplantation autologous bone marrow mesenchymal stem cells (ABMSCs) promising therapies for patients with HBV-related liver (HBV-LC). However, mechanism unclear. The aim current study was to explore role Treg/Th17 in ABMSCs HBV-LC.In this prospective study, 56 were enrolled randomly assigned group control group. After 24-week follow-up, 39 completed (20 cases 19 group). Model End-Stage Disease scores,...
Fibroblasts play a pivotal role in the process of cutaneous wound repair, whereas their migratory ability under diabetic conditions is markedly reduced.In this study, we investigated effect basic fibroblast growth factor (bFGF) on human dermal migration high-glucose environment.bFGF significantly increased by increasing percentage fibroblasts with high polarity index and reorganizing F-actin.A significant increase intracellular reactive oxygen species (ROS) was observed following bFGF...
The present study aimed at identifying the clinical, radiological and pathological characteristics of retroperitoneal paragangliomas, determining association between tumor features prognosis patients following surgery. A total 34 with who underwent resection November 1999 December 2015, were included in retrospective study. patients' demographics, clinical symptoms signs, functional status, surgical procedure, intraoperative results, pathology, postoperative survival time recorded analyzed....
Clinicians have been faced with the challenge of differentiating between severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) infected pneumonia (NCP) and influenza A (IAP), a seasonal disease that coincided outbreak. We aim to develop machine-learning algorithm based on radiomics distinguish NCP from IAP by texture analysis computed tomography (CT) imaging. Forty-one 37 patients admitted January February 6, 2019 two hospitals in Wenzhou, China. All had undergone chest CT...
Accurate diagnosis of intrahepatic cholangiocarcinoma (ICC) caused by lithiasis (IHL) is crucial for timely and effective surgical intervention. The aim the present study was to develop a nomogram identify ICC associated with IHL (IHL-ICC).The included 2,269 patients IHL, who received pathological after hepatectomy or diagnostic biopsy. Machine learning algorithms including Lasso regression random forest were used important features out available features. Univariate multivariate logistic...
RATIONALE/HYPOTHESIS: Forkhead box protein P1 (FOXP1) is one member of the forkhead P (FOXP) subfamily, which are transcription factors that mediate signaling and affect gene regulation, elevated expression FOXP1 has been reported to correlate with poor prognosis diffuse large B-cell lymphoma (DLBCL). Recently, it was also found occurs in mucosa-associated lymphoid tissue (MALT) lymphomas.FOXP1 its relationship morphology a series 43 gastric MALT lymphomas were investigated...
Basic fibroblast growth factor (bFGF) and nerve (NGF) are essential for proper development, survival, growth, maintenance of neurons in the central peripheral nervous systems. However, because bFGF NGF have short half-life rapid diffusion rate, they limited clinical efficacy. Thus, there is an urgent need to develop effective delivery system protect from proteolysis while maintaining their normal bioactivities.To more efficiently deliver NGF, we used a coacervate (synthesized with heparin...
Cholangiocarcinoma (CCA) is a fatal disease with dismal survival rates. Long non-coding RNA (lncRNA) expression profiling as potential prognostic biomarkers play critical roles in tumor initiation, development, and poor prognosis. Identifying specific lncRNA to predict the prognosis of CCA patients early stages very important for improving patient's survival. In current study, we aimed establish novel risk-stratification signature panel CCA. The initial discovery was identified Cancer Genome...
This study was conducted with the intent to develop and validate a radiomic model capable of predicting intrahepatic cholangiocarcinoma (ICC) in patients lithiasis (IHL) complicated by imagologically diagnosed mass (IM).A developed training cohort 96 IHL-IM from January 2005 July 2019. Radiomic characteristics were obtained arterial-phase computed tomography (CT) scans. The score (rad-score), based on features, built logistic regression after using least absolute shrinkage selection operator...
Accurate preoperative diagnosis of intrahepatic cholangiocarcinoma (ICC) among patients with imagiologically lithiasis (IHL) complicated by mass is crucial for timely and effective surgical intervention. The aim the present study was to develop a nomogram identify ICC associated IHL (IHL-ICC).Data were obtained from total 252 consecutive mass. Multivariate logistic regression analysis conducted clinicopathologic imagiological characteristics that potentially ICC. A developed based on results...
AIM:To analyze the factors influencing radical (R0) resection rate and surgical outcome for malignant tumor of pancreatic body tail. METHODS:The clinical operative data followup results 214 tail cancer patients were analyzed retrospectively. RESULTS:One hundred twenty/214 underwent treatment; overall was 59.2% (71/120), R0 40.8% (49/120).Compared with non-R0 treatment, receiving an had smaller size (P < 0.01), cystadenocarcinoma less lymph node metastasis peri-pancreatic organ involvement...
Abstract Aim Radical surgery of rectal cancer is associated with significant morbidity, and some patients low‐lying lesions must accept a permanent colostomy. The objective this study was to evaluate the outcome local excision followed by adjuvant radiotherapy for curative purposes. Method One hundred seven carcinoma performed were analysed retrospectively. Results procedures trans‐anal resection in 83 patients, trans‐sacral 16, trans‐sphincteric five, trans‐vaginal three. overall...
Objective. The aim of this study was to develop and describe an experimental canine model portal hypertension with hypersplenism. Material methods. Twenty-five dogs were used randomly divided into three groups: group I (control group, n = 5), II (PVS, 10) III (PVS + SVS, 10). Portal vein stenosis (PVS) performed in II; the first prepared by PVS additional splenic 3 weeks later SVS). pressure (PVP), length spleen fluctuation hematocyte counts measured recorded at appointed times. Surgery...