A5100678990- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Fibroblast Growth Factor Research
- MicroRNA in disease regulation
- Kruppel-like factors research
- Diet, Metabolism, and Disease
- Epigenetics and DNA Methylation
- Macrophage Migration Inhibitory Factor
- Mesenchymal stem cell research
- Organ Transplantation Techniques and Outcomes
- Glioma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Inflammatory Bowel Disease
- Microbial Metabolism and Applications
- Plant Reproductive Biology
- Hepatitis Viruses Studies and Epidemiology
- CAR-T cell therapy research
Wenzhou Medical University
2016-2025
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Fruit Research Institute
2021-2024
Guangzhou Medical University
2021-2023
Tsinghua University
2020
Beijing Tsinghua Chang Gung Hospital
2020
Chongqing Three Gorges Central Hospital
2019
Fudan University Shanghai Cancer Center
2015
Wenzhou University
2015
657 Oslo
2008-2014
The definition of acute-on-chronic liver failure (ACLF) based on cirrhosis, irrespective aetiology, remains controversial. This study aimed to clarify the clinicopathological characteristics patients with hepatitis B virus-related ACLF (HBV-ACLF) in a prospective and develop new diagnostic criteria prognostic score for such patients.The clinical data from 1322 hospitalised acute decompensation cirrhosis or severe injury due chronic (CHB) at 13 centres China were used criteria.Of assessed...
microRNA (miRNA) expression profiles varied greatly among current studies due to different technological platforms and small sample size. Systematic integrative analysis of published datesets that compared the miRNA between hepatocellular carcinoma (HCC) tissue paired adjacent noncancerous liver was performed determine candidate HCC associated miRNAs. Moreover, we further validated confirmed miRNAs in a clinical setting using qRT-PCR Tumor Cancer Genome Atlas (TCGA) dataset. A...
Abstract Background and Aims NAFLD represents an increasing health problem in association with obesity diabetes no effective pharmacotherapies. Growing evidence suggests that several FGFs play important roles diverse aspects of liver pathophysiology. Here, we report a previously unappreciated role FGF4 the liver. Approach Results Expression hepatic is inversely associated pathological grades both human patients mouse models. Loss Fgf 4 aggravates steatosis damage resulted from obesogenic...
Liver cirrhosis is one of the major consequences hepatitis B virus (HBV) infection, and transplantation autologous bone marrow mesenchymal stem cells (ABMSCs) promising therapies for patients with HBV-related liver (HBV-LC). However, mechanism unclear. The aim current study was to explore role Treg/Th17 in ABMSCs HBV-LC.In this prospective study, 56 were enrolled randomly assigned group control group. After 24-week follow-up, 39 completed (20 cases 19 group). Model End-Stage Disease scores,...
Abstract Fibroblast growth factor 21 (FGF21) is a hepatokine that regulates glucose and lipid metabolism in the liver. We sought to determine role of FGF21 hepatic steatosis mice exposed chronic alcohol treatment discern underlying mechanisms. Male knockout (FGF21 KO) control (WT) were divided into groups fed either Lieber DeCarli diet containing 5% or an isocaloric (control) for 4 weeks. One group WT received recombinant human (rhFGF21) last 5 days. Liver inflammation assessed. Primary...
MicroRNA-223-3p (miR-223-3p) is one of the potential microRNAs that have been shown to alleviate inflammatory responses in pre-clinical investigations and highly encased exosomes derived from bone mesenchymal stem cells (MSC-exosomes). MSC-exosomes are able function as carriers deliver into cells. Autoimmune hepatitis challenging liver diseases with no effective treatment other than steroid hormones. Here, we examined whether can transfer miR-223-3p treat autoimmune an experimental model. We...
Abstract Salvigenin is a Trimethoxylated Flavone enriched in Scutellariae Barbatae Herba and Radix demonstrated to have anti-tumor properties colon cancer. Notwithstanding, the function mechanism of hepatocellular carcinoma (HCC) are less well studied. Different doses were taken treat HCC cells. Cell viability, colony formation ability, cell migration, invasion, apoptosis, glucose uptake, lactate production levels detected. As shown by data, concentration dependently dampened proliferation,...
Kinesin family member 20A (KIF20A) is an essential regulator of cytokinesis. In this study, by performing a retrospective study based on data from the Cancer Genome Atlas (TCGA)-Liver and Hepatocellular Carcinoma (LIHC) cohort, we tried to assess independent prognostic value KIF20A in terms overall survival (OS) recurrence-free (RFS). Results showed that normal liver tissues had very low expression compared with other cohorts TCGA. However, primary HCC (N = 371) significantly elevated than...
Background Alcoholic liver disease (ALD) is exacerbated by disruptions in intestinal microecology and immune imbalances within the gut–liver axis. The present study assesses therapeutic potential of combining Akkermansia muciniphila ( A. ) with inosine alleviating alcohol-induced injury. Methods Male C57BL/6 mice, subjected to a Lieber-DeCarli diet 5% alcohol for 4 weeks, served as alcoholic injury model. Various analyzes, including quantitative reverse transcription polymerase chain...
Hepatitis B surface antigen (HBsAg) seropositivity is an important risk factor for hepatocellular carcinoma (HCC), and HBsAg-transgenic mice have been reported to spontaneously develop HCC. The major histocompatibility complex class I-related molecules A (MICA MICB) are NKG2D ligands that play roles in tumor immune surveillance. In the present study, we found HBsAg overexpression HepG2 cells led upregulation of 133 downregulation 9 microRNAs (miRNAs). Interestingly, several HBsAg-induced...