A5075828120- Cytokine Signaling Pathways and Interactions
- Pulmonary Hypertension Research and Treatments
- Cancer Mechanisms and Therapy
- Bioactive Compounds and Antitumor Agents
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ferroptosis and cancer prognosis
- Fibroblast Growth Factor Research
- Respiratory Support and Mechanisms
- RNA modifications and cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- PI3K/AKT/mTOR signaling in cancer
- Inflammatory Bowel Disease
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Lung Cancer Treatments and Mutations
- Circular RNAs in diseases
- Kruppel-like factors research
- Cancer, Lipids, and Metabolism
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Congenital Diaphragmatic Hernia Studies
- Natural product bioactivities and synthesis
Wenzhou Medical University
2015-2025
First Affiliated Hospital of Wenzhou Medical University
2015-2025
Guangxi University
2025
Tianjin University
2025
Ningbo University
2025
Hangzhou Xixi hospital
2024
Guangxi Normal University
2024
Ningxia Medical University
2024
Ningxia Medical University General Hospital
2024
Jiangxi University of Traditional Chinese Medicine
2011-2022
Highlights•Salidroside improves chronic hypoxia-induced pulmonary arterial hypertension.•Salidroside reverses apoptosis resistance in PASMCs.•Salidroside modulates cell via mitochondria-dependent pathway upregulates adenosine A2a receptor expression under hypoxia conditionsAbstractPulmonary hypertension (PAH) is characterized by remodeling mainly due to excess cellular proliferation and of smooth muscle cells (PASMCs). Salidroside, an active ingredient isolated from Rhodiola rosea proposed...
Dendritic cells (DCs) play a pivotal role as initiators in the pathogenesis of inflammatory bowel disease and are regulated by JAK/STAT/SOCS signaling pathway. As potent anti-inflammatory compound, curcumin represents viable treatment alternative or adjunctive therapy management chronic (IBD). The mechanism treated IBD on DCs is not completely understood. In present study, we explored experimental colitis observing activation via pathway mice. Experimental was induced 2, 4, 6-trinitrobenzene...
Rhein is a lipophilic anthraquinone extensively found in medicinal herbs. Emerging evidence suggests that rhein has significant antitumor effects, supporting its potential use as an agent. The IL6/STAT3 signaling pathway been suggested attractive target for the discovery of novel cancer therapeutics.The human pancreatic cell lines AsPC-1, Patu8988T, BxPC-3 and PANC-1, immunodeficient mice were chosen models to study effects rhein. potent antiproliferative proapoptotic examined by viability,...
Shc SH2-domain binding protein 1 (SHCBP1), a specific to SH2 domain of Src homolog and collagen (Shc), takes part in the regulation various signal transduction pathways, which has been reported be associated with tumorigenesis progression. However, pathological mechanisms are not completely investigated. Thus, this study aimed comprehensively elucidate potential functions SHCBP1 multiple cancer types. The comprehensive analyses for tumors, including gene expression, diagnosis, prognosis,...
Lung cancer is the leading cause of cancer-related deaths worldwide, and ∼85% lung cancers are classified as nonsmall cell (NSCLC). These malignancies can proliferate indefinitely, in part due to dysregulation cycle resulting abnormal growth. The specific activation cyclin-dependent kinases 4 6 (CDK4/6) closely linked tumour proliferation. Approximately 80% human tumours exhibit abnormalities cyclin D-CDK4/6-INK4-RB pathway. Specifically, CDK4/6 inhibitors either monotherapy or combination...
This study proposes a flow field modeling analysis of kitchen environments with air-conditioning range hoods. The substructure approach is applied to resolve the challenges low computational efficiency and convergence difficulties associated simultaneous consideration hood cooling fan impeller rotation models. presented effectively enhances while ensuring accuracy. A was performed in Fluent obtain velocity contour plot at outlet monitoring surface. data were then mapped full model enable...
Baicalin, an important flavonoid in Scutellaria baicalensis Georgi extracts, exerts a variety of pharmacological effects. In this study, we explored the effects baicalin on chronic hypoxia-induced pulmonary arterial hypertension (PAH) and investigated mechanism underlying these Moreover, examined whether inflammatory response was mediated by A2A receptor (A2AR) stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine type 4 (CXCR4)-induced phosphatidyl inositol-3-kinase (PI3K) signaling vivo....
Non-small cell lung cancer (NSCLC) is the most common with high mortality across world, but it challenging to develop an effective therapy for NSCLC. Celastrol a natural bioactive compound, which has been found possess potential antitumor activity. However, underlying molecular mechanisms of celastrol activity in NSCLC remain elusive.Cellular function assays were performed study suppressive role human cells (H460, PC-9, and H520) bronchial epithelial BEAS-2B. Cell apoptosis levels analyzed...
Previous studies on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) have found that those who died in hospital had higher blood urea nitrogen levels and a worse nutritional status compared to survivors. However, the association between serum albumin ratio (BUN/ALB ratio) in-hospital short-term prognosis patients with AECOPD remains unclear. The aim this study was explore usefulness BUN/ALB as an objective predictor for 90-day all-cause mortality.We recorded laboratory...
Several studies have implicated the feedback activation of signal transducer and activator transcription 3 (STAT3) as a new cancer drug‐resistance mechanism linked it to failure epidermal growth factor receptor (EGFR)‐targeted therapies. In this study, we discovered that Alantolactone, natural sesquiterpene lactone, potently inhibited human pancreatic cells suppressed constitutively activated STAT3. contrast, Alantolactone had little effect on EGFR pathway. Moreover, combination an...
The primary pulmonary lymphoma (PPL), with a low incidence, was highly misdiagnosed in clinic. present study analyzes the clinical features, laboratory and imaging data, pathologic characteristics, summarizes misdiagnosis reasons of PPL cases, aims to provide better understanding increase accuracy early diagnosis minimize PPL. data 19 cases were collected from first affiliated hospital Wenzhou medical university (PRC) April 2010 May 2016. All confirmed by pathology. process described. This...
Abstract Background Cyclin-dependent kinase 9 (CDK9) is a promising prognostic marker and therapeutic target in cancers. Bufalin an effective anti-tumour agent; however, the clinical application of bufalin limited due to its high toxicity. Acetyl-bufalin, prodrug, was designed synthesised with higher efficiency lower Methods Three non-small-cell lung cancer (NSCLC) cell lines, xenograft model patient-derived (PDX) were used examine effects acetyl-bufalin. CDK9/STAT3 involvement investigated...
Background and Purpose Pulmonary arterial hypertension (PAH) is a pulmonary vasculature obstructive disease that leads to right heart failure death. Maresin 1 an endogenous lipid mediator known promote inflammation resolution. However, the effect of on PAH remains unclear. Experimental Approach The serum concentration was assessed using UPLC. A mouse model established by combining Sugen 5416 injection hypoxia exposure. After treatment with 1, ventricular systolic pressure (RVSP) function...
Lung adenocarcinoma (LUAD) is associated with poor prognosis. Identifying novel cancer targets and helpful therapeutic strategies remains a serious clinical challenge. This study detected differentially expressed genes in The Cancer Genome Atlas (TCGA) LUAD data collection. We also identified predictive DNA biomarker, G protein-coupled receptor 37 (GPR37), which was verified as prognostic biomarker critical role tumor progression. In human specimens microarray analyses, we determined that...
AIM:To explore probable mechanism underlying the therapeutic effect of Astragalus polysaccharide (APS) against experimental colitis. METHODS:Thirty-two Sprague-Dawley rats were randomly divided into four groups.Colitis was induced with 2, 4, 6-trinitrobenzene sulfonic acid (TNBS).The colitis treated 400 mg/kg APS for 7 d.The evaluated by colonic weight, weight index colon, length, and macroscopic histological scores.The levels regulatory T (Treg) cells in Peyer's patches measured flow...
Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a bifunctional enzyme located in the mitochondria. It has been reported to be overexpressed several malignancies. However, relationship between expression of MTHFD2 and non-small cell lung cancer (NSCLC) remains largely unknown. In this study, we found that was significantly NSCLC tissues lines. Knockdown resulted reduced growth tumorigenicity vitro vivo. Besides, mRNA protein level cycle genes, such as CCNA2, MCM7 SKP2, decreased...
Kinesin family member 20A (KIF20A) is an essential regulator of cytokinesis. In this study, by performing a retrospective study based on data from the Cancer Genome Atlas (TCGA)-Liver and Hepatocellular Carcinoma (LIHC) cohort, we tried to assess independent prognostic value KIF20A in terms overall survival (OS) recurrence-free (RFS). Results showed that normal liver tissues had very low expression compared with other cohorts TCGA. However, primary HCC (N = 371) significantly elevated than...
Non-small-cell lung cancer (NSCLC) comprises about 85% of all cancers and is usually diagnosed at an advanced stage with poor prognosis. The IL-6/STAT3 signaling pathway plays a pivotal role in NSCLC biology. Rhein lipophilic anthraquinone extensively found medicinal herbs. Emerging evidence suggests that has significant antitumor effects, supporting the potential uses as agent.
Twelve novel 7'-hydroxy lignan glucosides (1-12), including two benzofuran-type neolignans, 8-O-4' dibenzylbutyrolactone lignans, and six tetrahydrofuranoid together with known (13-18), were isolated from the fruit of Arctium lappa L. (Asteraceae), commonly as Arctii Fructus. Their structures elucidated using spectroscopy (1D 2D NMR, MS, IR, ORD, UV) on basis chemical evidence. The absolute configurations compounds 1-12 confirmed rotating frame nuclear overhauser effect (ROESY), circular...
Abstract Asiaticoside (AS) has been reported to have protective effect on pulmonary fibrosis (PF). In this study, we aimed explore the potential mechanism of therapeutic role AS and its relationship with A2AR in PF. Adenosine 2A receptor gene knockout (A2AR −/− ) mice wild‐type (WT) were used establish bleomycin (BLM)‐induced PF models then treated (50 mg/kg/d). Pulmonary inflammation observed model much higher severity than that WT significantly alleviated lung fibrosis; however, it was...