A5101856577- Sphingolipid Metabolism and Signaling
- Lipid Membrane Structure and Behavior
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Muscle Physiology and Disorders
- Genetic Neurodegenerative Diseases
- Nicotinic Acetylcholine Receptors Study
- Advanced Graph Neural Networks
- Cancer, Lipids, and Metabolism
- Diet, Metabolism, and Disease
- Heat shock proteins research
- Medicinal Plants and Neuroprotection
- Mesenchymal stem cell research
- Caching and Content Delivery
- Multiple Sclerosis Research Studies
- Inflammasome and immune disorders
- Neuroscience and Neuropharmacology Research
- Natural product bioactivities and synthesis
- S100 Proteins and Annexins
Yunnan University
2024
Wenzhou University
2022-2024
China Medical University
2024
Harbin Institute of Technology
2024
Washington University in St. Louis
2021-2023
Wenzhou Medical University
2015-2022
Mallinckrodt (United States)
2022
The People's Hospital of Guangxi Zhuang Autonomous Region
2021
Beijing HuiLongGuan Hospital
2021
Nanjing University of Science and Technology
2014-2015
The interactions among the gut, liver, and immune system play an important role in liver disease. Probiotics have been used for treatment prevention of many pathological conditions, including diseases. Comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOF MS) was herein, conjunction with chemometric data analysis, to identify metabolites significantly affected by probiotics mice fed or without alcohol. metabolomics analysis indicates that levels fatty...
Lung adenocarcinoma (LUAD) is associated with poor prognosis. Identifying novel cancer targets and helpful therapeutic strategies remains a serious clinical challenge. This study detected differentially expressed genes in The Cancer Genome Atlas (TCGA) LUAD data collection. We also identified predictive DNA biomarker, G protein-coupled receptor 37 (GPR37), which was verified as prognostic biomarker critical role tumor progression. In human specimens microarray analyses, we determined that...
DNA methylation is one of the essential epigenetic mechanisms that are closely correlated with underlying cell growth, differentiation and transformation in eukaryotes. Global changes landscape considered to be a hallmark cancer. The initiation progression cancer mediated through modifications along genetic alterations. Aberrant promoter regions an abnormality human genome highly characteristic In this review, we aimed summarize our current understanding alterations investigate potential use...
Sphingosine-1-phosphate receptor 1 (S1PR1) is ubiquitously expressed among all tissues and plays key roles in many physiological cellular processes. In the central nervous system (CNS), S1PR1 different types of cells including neurons, astrocytes, oligodendrocyte precursor cells. has been recognized as a novel therapeutic target multiple sclerosis other diseases. We previously reported promising S1PR1-specific radioligand, [11C]CS1P1 (previously named [11C]TZ3321), which under clinical...
Sphingosine-1-phosphate receptor 1 (S1PR1) is recognized as a novel therapeutic and diagnostic target in neurological disorders. We recently transferred the S1PR1 radioligand [11C]CS1P1 into clinical investigation for multiple sclerosis. Herein, we reported design, synthesis evaluation of F-18 radioligands. combined structural advantages our two lead radioligands synthesized 14 new compounds, then performed radiochemistry on most promising compounds. Compound 6h potent (IC50 = 8.7 nM)...
N 6 -methyladenosine (m A) is the most abundant chemical modification in eukaryotic cells. It a post-transcriptional of mRNA, dynamic reversible process catalyzed by methyltransferase, demethylase, and binding proteins. Ferroptosis, unique iron-dependent cell death, regulated various metabolic events, including many disease-related signaling pathways. And different ferroptosis inducers or inhibitors have been identified that can induce inhibit onset through targets mechanisms. They potential...
This study evaluated the safety, dosimetry, and characteristics of 3-((2-fluoro-4-(5-(2'-methyl-2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1,2,4-oxadiazol-3-yl)benzyl)(methyl-
A promising sphingosine-1-phosphate receptor 1 PET radiotracer [ 18 F]FS1P1 was synthesized using a facile multiple step F-18 radiochemistry procedure.
Piperine (1-piperoylpiperidine) is the major pungent component of black pepper (Piper nigrum) and exhibits a spectrum pharmacological activities. The molecular bases for many piperine’s biological effects are incompletely defined. We noted that chemical structure piperine generally conforms to pharmacophore model small bioactive molecules activate mitofusin (MFN)-mediated mitochondrial fusion. Piperine, but not its isomer chavicine, stimulated fusion in MFN-deficient cells with EC50 ~8 nM....
The role of circular RNA (circRNA) pappalysin 1 (circ-PAPPA; hsa_circ_0088233) in prostate cancer (PCa) cells was explored the current study. Circ-PAPPA abundance markedly enhanced PCa. interference restrained cell viability, proliferation, motility and glycolysis while elevated apoptosis rate PCa cells. negatively regulated microRNA-515-5p (miR-515-5p) abundance. MiR-515-5p silencing largely diminished circ-PAPPA knockdown-mediated effects directly bound to FKBP prolyl isomerase 1A...
Sphingosine-1-phosphate receptor 1 (S1PR1) plays a crucial role in infectious diseases. Targeting S1PR1 provides protection against pathogens, such as influenza viruses. This study is aimed at investigating response to bacterial infection by assessing expression S. aureus-infected mice. A rodent local muscle model was developed injecting aureus the lower hind limb of Balb/c The changes and blocking treatment were assessed using ex vivo biodistribution positron emission tomography (PET) after...
Circular RNAs (circRNAs) have been reported to play an important role in the progression of numerous types human cancer. The aim present study was determine effects circRNA_0074027 (circ_0074027) gastric cancer (GC), and elucidate underlying mechanisms action. For this purpose, expression circ_0074027 GC cell lines detected using reverse transcription‑quantitative PCR. on proliferation migration cells were investigated Cell Counting Kit‑8 (CCK‑8) Transwell assays, respectively. RNA...
Drug resistance is a key factor affecting the treatment of gastric cancer. The cancer cells to anticancer drugs, such as cisplatin (DDP), remains major challenge patient recovery. present study aimed investigate roles C‑terminal‑binding protein 1 (CTBP1) in DDP and determine its regulatory effect on DNA repair RAD51 homolog (RAD51). DDP‑resistant human AGS HGC cell lines, AGS/DDP HGC‑27/DDP, respectively, were established CTBP1 expression was detected by western blotting. In addition, Cell...
Objective. To observe the clinical effects of Jiawei Danggui Beimu Kushen pills in treating prostate cancer and their influence on expression serum specific antigen. Methods. A total 234 patients were selected randomly divided into observation group control group, with 117 cases each group. The was given oral bicalutamide tablets, while treated basis treatment efficacy, IPSS score, TCM syndrome VAS quality-of-life immune function two groups compared before after treatment. PSA f-PSA levels...