A5082119803- Virus-based gene therapy research
- Cell death mechanisms and regulation
- Corneal Surgery and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Bacterial Genetics and Biotechnology
- Pharmacogenetics and Drug Metabolism
- Fibroblast Growth Factor Research
- Computational Drug Discovery Methods
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Herpesvirus Infections and Treatments
- Medical Imaging Techniques and Applications
- Ion Channels and Receptors
- Neuroblastoma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- NF-κB Signaling Pathways
- Cancer Research and Treatments
- bioluminescence and chemiluminescence research
- CRISPR and Genetic Engineering
- Connexins and lens biology
- Liver physiology and pathology
- DNA Repair Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Phytochemicals and Antioxidant Activities
- Radiopharmaceutical Chemistry and Applications
Hainan Normal University
2025
University of California, Davis
1992-2024
Eli Lilly (United States)
2015-2022
Washington University in St. Louis
2019-2022
Siemens (United States)
2009-2013
Siemens Healthcare (United States)
2013
Sun Yat-sen University
2006
University of California, Los Angeles
1995-2004
Institute for Molecular Medicine
2002
Cleveland Clinic
1997-1999
We wished to develop a highly selective positron emission tomography (PET) imaging agent targeting PHF-tau in human Alzheimer's disease (AD) brains.To screen potential tau binders, AD brain sections were used as source of native paired helical filament (PHF)-tau and Aβ rather than synthetic aggregates or fibrils generated vitro measure the affinity selectivity [(18)F]T807 Aβ. Brain uptake biodistribution mice also tested.In autoradiography results show that exhibits strong binding...
We are developing assays for noninvasive, quantitative imaging of reporter genes with positron emission tomography (PET), application both in animal models and human gene therapy. report here a method to improve the detection lower levels PET expression by utilizing mutant herpes simplex virus type 1 thymidine kinase (HSV1-sr39tk) as gene. The HSV1-sr39tk was identified from library site-directed mutants. Accumulation (net uptake) radioactively labeled substrates [8- 3 H]penciclovir ([8-...
Senile plaques and neurofibrillary tangles are prominent neuropathological hallmarks in Alzheimer's disease considered to be targets for therapeutic intervention as well biomarkers diagnostic vivo imaging agents. While there a n
Gene therapy protocols are hampered by the inability to monitor location, magnitude, and duration of ectopic gene expression following DNA delivery. Consequently, it is difficult establish quantitative correlations and/or causal relationships between therapeutic phenotypic responses in treated individuals. One approach "therapeutic gene" indirectly incorporate reporter genes that can be imaged vivo into bicistronic transcription units, along with genes. Expression dopamine D2 receptor (D2R)...
We have previously validated the use of micro-positron emission tomography (microPET) for monitoring expression a single PET reporter gene in rat myocardium. now report bicistronic adenoviral vector (Ad-CMV-D2R80a-IRES-HSV1-sr39tk) linking 2 genes, mutant dopamine type receptor (D2R80a) and herpes simplex virus 1 thymidine kinase (HSV1-sr39tk), with aid an internal ribosomal entry site (IRES).Rat H9c2 cardiomyoblasts transduced increasing titers Ad-CMV-D2R80a-IRES-HSV1-sr39tk (0 to 2.5x10(8)...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExpression and characterization of human lactoferrin in yeast Saccharomyces cerevisiaeQianwa. Liang Tom. RichardsonCite this: J. Agric. Food Chem. 1993, 41, 10, 1800–1807Publication Date (Print):October 1, 1993Publication History Published online1 May 2002Published inissue 1 October 1993https://pubs.acs.org/doi/10.1021/jf00034a053https://doi.org/10.1021/jf00034a053research-articleACS PublicationsRequest reuse permissionsArticle...
Four new p-terphenyl derivatives named phenylcandilides C-F, together with nine known analogues, were isolated from the deep-sea cold-seep-derived fungus Aspergillus candidus HNNU0546. Compounds 10 and 12 exhibited antibacterial activity against Staphylococcus aureus MIC values of 21.6 23.6 µM, respectively. Compound 5 showed antifungal an EC50 value 3.0 µM phytopathogenic Alternaria sp., while compound 6 inhibitory Curvularia australiensis sp. same
[18F]-labeled positron emission tomography (PET) radioligands permit in vivo assessment of Alzheimer's disease biomarkers, including aggregated neurofibrillary tau (NFT) with [18F]flortaucipir. Due to structural similarities flortaucipir some monoamine oxidase A (MAO-A) inhibitors, this study aimed evaluate binding MAO-A and MAO-B any potential impact on PET interpretation.[18F]Flortaucipir autoradiography was performed frozen human brain tissue slices, imaging conducted rats. Dissociation...
The transient receptor potential channel subfamily member 5 (TRPC5) is a calcium permeable cation widely expressed in the brain. Accumulating evidence indicates that it plays crucial role psychiatric disorders including depression and anxiety. Positron emission tomography (PET) combined with TRPC5 specific radioligand may provide unique tool to investigate functions of animal disease models guide drug development targeting TRPC5. To develop PET radiotracer, potent inhibitor HC608 was chosen...