A5103035978- Cytokine Signaling Pathways and Interactions
- Cancer Mechanisms and Therapy
- Curcumin's Biomedical Applications
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- PI3K/AKT/mTOR signaling in cancer
- Pharmacological Effects of Medicinal Plants
- Medicinal Plant Pharmacodynamics Research
- Fibroblast Growth Factor Research
- Synthesis and biological activity
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Tuberculosis Research and Epidemiology
- Protein Tyrosine Phosphatases
- Phytochemistry and biological activity of medicinal plants
- Synthesis of Organic Compounds
- Ubiquitin and proteasome pathways
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- 14-3-3 protein interactions
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Renal Diseases and Glomerulopathies
- Pancreatitis Pathology and Treatment
- Mycobacterium research and diagnosis
Wenzhou Medical University
2016-2025
China Medical University
2013-2024
Wenzhou University
2019-2024
Nanjing Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2020-2023
Nanjing University of Science and Technology
2015
Nationwide Children's Hospital
2015
The Ohio State University
2015
Lung cancer is the leading cause of cancer-related deaths worldwide and non-small cell lung (NSCLC) accounts for over 80% cases. The RNA binding protein, QKI, belongs to STAR family plays tumor-suppressive functions in NSCLC. QKI-5 a major isoform QKIs predominantly expressed However, underlying mechanisms NSCLC progression remain unclear. We found that regulated microRNA (miRNA), miR-196b-5p, its expression was significantly up-regulated tissues. Up-regulated miR-196b-5p promotes migration,...
Rhein is a lipophilic anthraquinone extensively found in medicinal herbs. Emerging evidence suggests that rhein has significant antitumor effects, supporting its potential use as an agent. The IL6/STAT3 signaling pathway been suggested attractive target for the discovery of novel cancer therapeutics.The human pancreatic cell lines AsPC-1, Patu8988T, BxPC-3 and PANC-1, immunodeficient mice were chosen models to study effects rhein. potent antiproliferative proapoptotic examined by viability,...
Curcumin exhibits a surprisingly wide range of chemo-preventive and chemo-therapeutic activities. has undergone more than 40 clinical trials for the treatment inflammatory diseases various human cancers. However, phase I/II have shown that curcumin exhibit poor bioavailability in humans. Major reasons resulting low plasma tissue levels appear to be its absorption, fast metabolism, rapid systemic elimination. It is suggested β-diketone moiety responsible instability weak pharmacokinetic...
Triple-negative breast cancer (TNBC) is an aggressive subgroup of human cancer. Patients with TNBC have poor clinical outcome as they are non-responsive to current targeted therapies. There urgent need identify new therapeutic targets and develop more effective treatment options for patients. Osthole, a natural product from C. monnieri, has been shown inhibit certain cells. However, the mechanisms action well its effect on cells not currently known.We investigated osthole in cultured...
Signal transducer and activator of transcription 3 (STAT3) is an oncogene, which upregulates in approximately 70% human cancers. Autophagy evolutionarily conserved process maintains cellular homeostasis eliminates damaged components. Moreover, the STAT3 signaling pathway, may be triggered by cancer cells, has been implicated autophagic process. In this study, we found that anthelmintic flubendazole exerts potent antitumor activity three colorectal (CRC) cell lines nude mouse model. The...
Several studies have implicated the feedback activation of signal transducer and activator transcription 3 (STAT3) as a new cancer drug‐resistance mechanism linked it to failure epidermal growth factor receptor (EGFR)‐targeted therapies. In this study, we discovered that Alantolactone, natural sesquiterpene lactone, potently inhibited human pancreatic cells suppressed constitutively activated STAT3. contrast, Alantolactone had little effect on EGFR pathway. Moreover, combination an...
Non-small-cell lung cancer (NSCLC) comprises about 85% of all cancers and is usually diagnosed at an advanced stage with poor prognosis. The IL-6/STAT3 signaling pathway plays a pivotal role in NSCLC biology. Rhein lipophilic anthraquinone extensively found medicinal herbs. Emerging evidence suggests that has significant antitumor effects, supporting the potential uses as agent.
K-Ras mutations are frequently detected in pancreatic and colon cancers, which associated with the resistance to MEK inhibitors targeting Ras pathway. Identifying underlying mechanisms for acquired is essential future clinical development of inhibitors. Here, we identified that Signal Transducer Activator Transcription 3 (STAT3) was significantly activated following inhibition using AZD6244, PD98059 Trametinib mutant cancer cells. The STAT3 activation may be important inhibitor these We have...
Abstract: Niclosamide, an anthelmintic drug approved by the US Food and Drug Administration against cestodes, is used to treat tapeworm infection. In this study, we show that niclosamide can potentially inhibit signal transducer activator of transcription 3 (STAT3) in colon cancer cell lines. Combined inhibition epidermal growth factor receptor STAT3 erlotinib synergistically induces apoptosis antiproliferation Our findings suggest combination provides effective therapeutic approach...
Abstract The attenuated degradation of articular cartilage by cartilage-specific deletion fibroblast growth factor receptor 1 (FGFR1) in adult mice suggests that FGFR1 is a potential target for treating osteoarthritis (OA). goal the current study was to investigate effect novel non-ATP-competitive inhibitor, G141, on catabolic events human chondrocytes and explants progression murine model OA. G141 screened identified via cell-free kinase-inhibition assay. In vitro study, decreased mRNA...
Objective: Nanoparticles can efficiently carry and deliver anticancer agents to tumor sites. Mounting evidence indicates that many types of cancer cells, including colon cancer, have a weakly acidic microenvironment increased levels reactive oxygen species. The construction nano drug delivery vehicles "activatable" in response the is new antitumor therapeutic strategy. Methods: Cinnamaldehyde (CA) was designed link directly with dextran form polymer through an acid cleavable acetal bond....
Activation of epidermal growth factor receptor (EGFR) has been reported in a variety cancer types, including colorectal (CRC), and represents potential chemotherapeutic drug target. EGFR tyrosine kinase inhibitors (EGFR-TKIs) have increasingly applied the clinical treatment CRC, but development resistance during greatly limited their application. Signal transducer activator transcription 3 (STAT3) its mediated signal transduction pathway play an important role occurrence, metastasis are...