A5019800005- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Ear Surgery and Otitis Media
- Asthma and respiratory diseases
- Nasal Surgery and Airway Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Magnetism in coordination complexes
- Allergic Rhinitis and Sensitization
- Organic and Molecular Conductors Research
- Tracheal and airway disorders
- Ear and Head Tumors
- Organometallic Complex Synthesis and Catalysis
- Occupational exposure and asthma
- Metal complexes synthesis and properties
- Oral and Maxillofacial Pathology
- Crystallization and Solubility Studies
- Congenital Ear and Nasal Anomalies
- Respiratory and Cough-Related Research
- Facial Nerve Paralysis Treatment and Research
- Dysphagia Assessment and Management
- Pituitary Gland Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Occupational and environmental lung diseases
- Meningioma and schwannoma management
- Fullerene Chemistry and Applications
Central Japan Railway (Japan)
2022-2024
Nishi Niigata Chuo National Hospital
2018-2024
National Hospital Organization
2022-2024
Niigata University
2007-2022
Showa University
2011-2021
National Institute for Agro-Environmental Sciences
1984-2021
The Japanese Society of Gastroenterological Surgery
2020
The University of Texas Health Science Center at Houston
2020
Toho University
2006-2019
Niigata University Medical and Dental Hospital
2002-2019
Eosinophils and nasal polyps are believed to affect the surgical outcome of chronic rhinosinusitis (CRS). CRS is classified based on presence in western countries. The majority patients with (CRS NP) characterized by predominantly eosinophilic inflammation. However, Asian NP show characteristics indicative neutrophilic Therefore, eosinophils or more important for classification CRS?A prospective cohort study conducted from April 2007 March 2008 mucosal eosinophilia. recurrence rate was...
Chronic rhinosinusitis (CRS) is one of the most frequent chronic diseases in US, and little understood about its pathogenesis. This study was conducted to characterize, retrospectively, clinical, objective immunological parameters that accompany recurrence CRS during long-term follow-up after surgery.Fifty-six patients with who had undergone endoscopic sinus surgery were followed up for 5 years surgery. The chosen as follows: history asthma and/or allergic rhinitis, peripheral eosinophilia...
To investigate whether endoscopic stapes surgery is safer and less invasive than conventional using an operating microscope.Retrospective study.The subjects were 15 patients (15 ears) who underwent for otosclerosis or congenital stapedial fixation. Another 35 (41 in whom microscopic was performed by the same surgeon assigned to control group. The procedures fundamentally as those surgery, unless there no anterior posterior auricular skin incision. two surgical techniques compared with...
Endoscopic medial maxillectomy (EMM) is a safe and effective procedure for treatment of inverted papilloma (IP) originating from the maxillary sinus. However, EMM usually removes inferior turbinate nasolacrimal duct. The has critical function in conditioning nasal airflow, resection ducts risk epiphora. We developed newly derived surgical technique, endoscopic modified (EMMM), which enables preservation duct.A retrospective case series six patients with IP nine mucoceles sinus after...
Abstract Dichloromethylene diphosphonate (MDPCl2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately transferred to lysosomes, then released from into lysosomes enzymatic digestion of the liposomal lipid layers. From 4 h after ingesting liposome-encapsulated MDPCl2 murine macrophages vivo and vitro acquired ultrastructural features apoptosis, such as condensed nuclear chromatin, fragmentation, cell shrinkage, blebbing plasma membrane. Murine...
Acquired multidrug resistance to anti-cancer agents has been associated with overexpression of the P-glycoprotein and other members ATP-binding cassette superfamily. The present studies demonstrate that SCC-25 cells selected for alkylating agent cisplatin (CDDP) overexpress anti-apoptotic Bcl-x<sub>L</sub> protein. In contrast parental cells, SCC-25/CDDP-resistant variant failed exhibit activation caspase-3, cleavage protein kinase C δ, characteristics apoptosis in response CDDP. Similar...
In the period from 1980 through 1989, we treated 25 (20 postoperative and five primary) cases of mucoceles posterior ethmoidal sinus and/or sphenoidal accompanied by visual disturbances. The mucocele developed 15 to years after initial surgery. Manifestations include headache, ophthalmalgia, double vision, exophthalmos in addition a decrease acuity. degree improvement acuity an operation depends on before operation, mode development mucocele, time onset disease until Opening endonasal...
Abstract The molecular status of the epidermal growth factor receptor (EGFR) has not been as well studied in head and neck squamous cell carcinoma (HNSCC) lung cancer. We examined frequencies EGFR mutations expression/phosphorylation protein HNSCC patients. Moreover, we tried to elucidate associations between patient characteristics disease-free survival. In this prospective cohort study, clinical data samples were obtained from 82 consecutive patients who had treated with targeting therapy....
Rationale: Recent studies suggest that host immune responses to environmental fungi may play an important role in the development of allergic diseases, such as human asthma. Epithelium is considered active participant inflammation. We previously reported aspartate protease from Alternaria induces activation and degranulation eosinophils are mediated through protease-activated receptor 2 (PAR-2). However, our current knowledge on innate epithelium very limited. investigated mechanisms these...
Coordination polymers showing redox activity have been constructed by using ferrocene-based bidentate ligands, 1,1'-(4-dipyridinethio)ferrocene (1) and 1,1'-(2-dipyridinethio)ferrocene (2). The ligand of 1 formed an AgI coordination polymer, 1·AgPF6·(CH3CN)2 (3). This complex showed a 1-D double-chain structure, with weak interchain Ag···Ag interaction. Combination M(hfac)2 (M = Mn, Cu, Zn) afforded chain complexes, 1·M(hfac)2 Mn (5), Cu (6), Zn (7)). 2·CuPF6 (8) twisted helix-like structure.
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Abstract Background Deregulation of the EGFR signaling pathway is one most frequently observed genetic abnormalities that drives cancer development. Although mutations in downstream components pathway, including KRAS, BRAF and PIK3CA, have been reported numerous cancers, extensive mutation copy number analysis these genes clinical samples has not performed for head neck squamous cell carcinoma (HNSCC). Methods We examined alterations PIK3CA 115 specimens HNSCC obtained from surgically...
The lack of protocols to predict the physical stability has been one most important issues in use amorphous solid dispersions. In this paper, crystallization behaviors pharmaceutical glasses, which have large variations their tendencies, investigated. Although each compound appears a wide variation time, initiation time for could be generalized as function only Tg/T, where Tg and T are glass transition temperature storage temperature, respectively. All compounds was mainly governed by had...
The pathophysiology of chronic rhinosinusitis (CRS) is not fully understood. In Europe and the United States, major subsets CRS classification are based on presence or absence polyps. Although nasal polyps (NPs) a critical factor, many other factors also contribute to pathogenesis CRS. aim this study was investigate diverse phenotypes using cluster analysis.This multicenter examining clinical data from patients treated at five hospitals. design retrospective analysis prospectively collected...
Fragility is a measure of the departure from non-Arrhenius behavior for supercooled liquids and glasses, various simple methods are available its quantification. However, obtained values usually do not agree with each other. One purposes this study was to compare fragility by different methodologies. Thermodynamic (FT) concept that evaluated heat capacity change at glass transition temperature (Tg). Dynamic using three methodologies in study: extrapolation configurational entropy (Sc)...
Sinus fungus ball is defined as noninvasive chronic fungal rhinosinusitis occurring in immunocompetent patients with regional characteristics. The clinical and imaging characteristics of paranasal sinus were retrospectively investigated 104 Japanese patients. All underwent endoscopic surgery. Preoperative computed tomography (CT), magnetic resonance (MR) imaging, age, sex, chief complaint, causative fungus, outcome analyzed. Patients aged from 25 to 79 years (mean 58.8 years). Female...
Rationale: Sirolimus has been shown in a randomized, controlled clinical trial to stabilize lung function patients with lymphangioleiomyomatosis (LAM) treated for 12-month time period; however the pretreatment decline after drug was discontinued indicated that continued exposure is required suppress disease progression.Objectives: To elucidate durability and tolerability of long-term sirolimus treatment Asian LAM.Methods: We conducted single-arm, open-label, investigator-initiated safety...
Forty-seven mucocoeles of the ethmoid and/or sphenoid sinuses (33 males, 14 females) were operated on during 10-years period from 1980 through 1989. Thirty-seven cases post-operative mucocoele, while remaining 10 so-called primary mucocoeles. None had a history facial trauma. In majority cases, mucocoele develops 15-24 years after initial surgery. Paranasal sinus surgery in young patients (teenagers) may lead to due scarring surgical wound. The principal symptoms include globe displacement,...
The prevalence of patients with chronic rhinosinusitis (CRS) refractory to traditional therapy appears be on the increase. In these cases, CRS tends associated bronchial asthma (BA), especially, aspirin-intolerant (AIA). On other hand, arachidonic acid metabolites have been extensively investigated in pathogenesis BA. We sought assess role prostaglandin D2 (PGD2) and E2 (PGE2) recalcitrant pathophysiology CRS. Samples were prepared from nasal polyps mucosa 40 undergoing endoscopic sinus...