A5051555588- Cancer and Skin Lesions
- Dermatology and Skin Diseases
- Cancer Immunotherapy and Biomarkers
- Nonmelanoma Skin Cancer Studies
- Autoimmune Bullous Skin Diseases
- Hedgehog Signaling Pathway Studies
- Eosinophilic Disorders and Syndromes
- Cutaneous lymphoproliferative disorders research
- Inflammatory Myopathies and Dermatomyositis
- Dermatological and Skeletal Disorders
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Skin and Cellular Biology Research
- melanin and skin pigmentation
- Tumors and Oncological Cases
- Skin Protection and Aging
- Hair Growth and Disorders
- Genomics, phytochemicals, and oxidative stress
- Skin Diseases and Diabetes
- Contact Dermatitis and Allergies
- Plant Reproductive Biology
- Cutaneous Melanoma Detection and Management
- Sarcoma Diagnosis and Treatment
- Wound Healing and Treatments
University of Tsukuba
2012-2025
Osaka University
2021-2025
University of Colorado Anschutz Medical Campus
2016-2018
University of Colorado Denver
2017
Gates (United States)
2017
Fukushima Medical University
2016
Kyoto University
2016
Toranomon Hospital
2012
Anti-programmed cell death protein 1 monoclonal antibodies (αPD-1mAbs) have been shown to be effective for advanced malignant melanoma. Treatment with αPD-1mAbs can also cause immune-related adverse events (irAEs). However, clinical predictive factors treatment responses or irAE risk remain unclear. To identify useful blood biomarkers response and occurrence of irAEs treatment. We retrospectively collected data from patients melanoma treated at the University Tsukuba Hospital. Clinical...
Aberrant immune responses to viral pathogens contribute pathogenesis, but our understanding of pathological caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019...
Objectives To investigate whether autoimmunity to transcriptional intermediary factor 1 (TIF1)γ, a ubiquitous nuclear autoantigen for myositis-specific autoantibodies detected in patients with dermatomyositis (DM) is pathogenetic inflammatory myopathy. Methods Wild-type, β 2 -microglobulin-null, perforin-null, Igμ‐null and interferon α/β receptor (IFNAR)-null mice were immunised recombinant human TIF1γ whole protein. A thymidine incorporation assay was performed using lymph node T cells from...
Recent clinical trials have demonstrated the efficacy of immune checkpoint inhibitors (ICIs) for treating melanoma. However, these previous studies comprised mainly Caucasian populations, in which cutaneous melanoma (CM) is major type. In contrast, Asian populations a distinct profile and show much higher frequencies acral lentiginous (ALM) mucosal (MCM). Compared with CM, ALM MCM poorer response to ICIs, but mechanisms not been fully understood. To evaluate status each subtype, we examined...
Abstract Recent studies have highlighted that human resident memory T cells (T RM ) are functionally distinct from circulating cells. Thus, it can be postulated skin age differently blood-circulating We assessed T-cell density, diversity, and function in individuals of various ages to study the immunologic effects aging on two different countries. No decline density was noted with advancing age, frequency epidermal CD49a + CD8 increased elderly regardless ethnicity. diversity antipathogen...
Non-melanoma skin cancer is the most frequently occurring type of worldwide and caused by epidermal carcinogenesis malignant progression that involve dysregulated expression proto-oncogenes tumor suppressor genes. The proto-oncogene pituitary tumor-transforming gene 1 (PTTG1) a ubiquitously expressed transcription factor can promote enhanced proliferation cultured keratinocytes. To investigate potential roles PTTG1 in progression, was analysed immunohistochemistry along with Ki67, keratin 10...
Although recent clinical trials have revealed that immune checkpoint inhibitors significantly improved the overall survival (OS) of patients with advanced melanoma, these previous studies comprised mainly white populations, in which superficial spreading melanoma (SSM) and lentigo maligna are major types melanoma. In contrast, Asians manifest a distinct clinicopathological type from whites show much higher frequencies acral lentiginous (ALM) mucosal been shown to be less susceptible...
Abstract Background Although basal cell carcinoma (BCC) is the most common type of skin cancer, incidence metastasis exceedingly low. Objective Case presentation a arising on dorsum foot with inguinal and pelvic lymph node metastases. Method literature review. Result On basis our review Japanese literature, risk factors for BCC are occurrence genitalia, diameter more than 3 cm, deep invasion tumor cells into extradermal structures, infiltrative/morpheic histological type. Conclusion from...
Loricrin is a major component of the epidermal cornified cell envelope and expressed only in terminally differentiated keratinocytes. This differentiation-specific expression pattern suggests specific regulatory mechanisms for activation loricrin gene transcription Here, we identified positive element proximal promoter region involved its A database search indicated that this sequence contained GATA-3 binding motif. Constructs with point mutations motif showed decreased reporter activity,...