A5035984140- Genomics, phytochemicals, and oxidative stress
- Muscle metabolism and nutrition
- Kruppel-like factors research
- Air Quality and Health Impacts
- Immune cells in cancer
- Venomous Animal Envenomation and Studies
- Air Quality Monitoring and Forecasting
- Liver Disease Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
- Silymarin and Mushroom Poisoning
- Phosphodiesterase function and regulation
- Wound Healing and Treatments
- Innovations in Medical Education
- Quinazolinone synthesis and applications
- Marine Sponges and Natural Products
- NF-κB Signaling Pathways
- Curcumin's Biomedical Applications
- Glycosylation and Glycoproteins Research
- Photosynthetic Processes and Mechanisms
- Bioactive Compounds and Antitumor Agents
- Phytochemicals and Antioxidant Activities
- Pomegranate: compositions and health benefits
- Muscle Physiology and Disorders
- Toxic Organic Pollutants Impact
- PI3K/AKT/mTOR signaling in cancer
Chungnam National University
2020-2025
Kyungpook National University
2023-2025
Inje University
2023
University of California, Los Angeles
2018
Rutaecarpine (RUT) is a bioactive alkaloid isolated from the fruit of Evodia rutaecarpa that exerts cellular protective effect. However, its effects on endothelial cells and mechanism action are still unclear. In this study, we demonstrated RUT nitric oxide (NO) synthesis via synthase (eNOS) phosphorylation in underlying molecular mechanisms. treatment promoted NO generation by increasing eNOS phosphorylation. Additionally, induced an increase intracellular Ca2+ concentration...
Oral squamous cell carcinoma (OSCC) is a prevalent oral and maxillofacial cancer with high mortality as OSCC cells readily invade tissues metastasize to cervical lymph nodes.Although imatinib exhibits potential anticancer remarkable clinical activities that therapeutically affect several types, its specific impact on has yet be fully explored.Therefore, this study investigated the effect of underlying mechanisms.The Cell Counting Kit-8 was used determine viability.Then, morphological...
Oral squamous cell carcinoma (OSCC) is an aggressive cancer with limited treatment options. Parishin A, a natural compound derived from
ABSTRACT This study aimed to identify the effects of major metal components present in particulate matter (PM)2.5 on reproductive system, sperm function, and embryo development. Through intratracheal instillation, male mice were exposed various concentrations components, including calcium oxide (Ca), iron (Fe), aluminum (Al), zinc (Zn), lead (Pb), a mixture these metals, PM2.5 collected from porcine farm. After 14 days, testicular inflammation abnormal morphology observed mice. These results...
Endothelial cells play a crucial role in cardiovascular health by maintaining vascular homeostasis, regulating blood flow and wall permeability, protecting against external stressors. Oxidative stress, particularly excessive reactive oxygen species (ROS), disrupts cellular homeostasis contributes to endothelial cell dysfunction. Rutaecarpine (RUT), an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa, has cytoprotective potential. However, the molecular mechanism underlying...
Skeletal muscle is a heterogeneous tissue composed of variety functionally different fiber types. Slow-twitch type I fibers are rich with mitochondria, and mitochondrial biogenesis promotes shift towards more slow fibers. Leucine, branched-chain amino acid (BCAA), regulates slow-twitch expression function. The BCAA content increased in porcine whole-blood protein hydrolysates (PWBPH) but the effect PWBPH on conversion unknown. Supplementation (250 500 mg/kg for 5 weeks) time to exhaustion...
Deinoxanthin, a xanthophyll derived from Deinococcus species, is unique organic compound that provides greater antioxidant effects compared to other carotenoids due its superior scavenging activity against singlet oxygen and hydrogen peroxide. Therefore, it has attracted significant attention as next-generation great potential natural ingredient in food supplements. Although the microbial identification of deinoxanthin been identified, mass production not yet achieved. Here, we report, for...
Betulinic acid (BA) is a natural pentacyclic triterpenoid with protective effects against inflammation, metabolic diseases, and cardiovascular diseases. We have previously shown that BA prevents endothelial dysfunction by increasing nitric oxide (NO) synthesis through activating synthase (eNOS) in human cells. However, the effect of on eNOS expression remains unclear. Thus, aim our study was to investigate intracellular pathways associated regulate significantly increased time-...
The white-rot fungi Ceriporia lacerata is used in bioremediation, such as lignocellulose degradation, nature. Submerged cultures and extracts of C. mycelia (CLM) have been reported to contain various active ingredients, including β-glucan extracellular polysaccharides, exert anti-diabetogenic properties mice cell lines. However, the immunostimulatory effects not yet reported. This study aimed identify immunomodulatory effects, underlying mechanisms thereof, submerged CLM using RAW264.7...
Inflammatory diseases are caused by excessive inflammation from pro-inflammatory mediators and cytokines produced macrophages. The Nrf2 signaling pathway protects against inflammatory inhibiting via the regulation of antioxidant enzymes, including HO-1 NQO1. We investigated anti-inflammatory effect impressic acid (IPA) isolated Acanthopanax koreanum on lipopolysaccharide (LPS)-induced underlying molecular mechanisms in RAW264.7 cells. IPA attenuated LPS-induced production reactive oxygen...
Background: Oral cancer is one of the most prevalent malignant tumors worldwide. Silibinin has been reported to exert therapeutic effects in various models. However, its mechanism action oral remains unclear. We aimed examine molecular processes underlying silibinin vitro and vivo as well potential anticancer effects. Next, we investigated both outcomes treatment on cancer. Methods: To investigate growth cells, cell proliferation anchorage-independent colony formation tests were conducted...
Patients with chronic hepatitis C virus (HCV) infection risk complications of cirrhosis, liver failure, and hepatocellular carcinoma (HCC). Previously, our proteomic examination hepatocytes carrying a HCV-replicon revealed that deregulation cytoskeletal dynamics may be potential mechanism viral-induced HCC growth. Here, we demonstrate the effect HCV replication on microtubule regulator stathmin (STMN1) in cells. We further explore how altered activity or synthesis affects cellular...
A number of studies have utilized blood waste as a bioresource by enzymatic hydrolysis to obtain amino acids, such branched-chain which can increase muscle mass or prevent loss during weight loss. Although significantly high content acids has been reported in porcine whole-blood protein hydrolysate (PWBPH), the effects PWBPH on skeletal differentiation and exercise function remain unclear. In this study, we investigated endurance ICR mice C2C12 mouse myoblasts gastrocnemius (Gas) mice....
Educational evaluation involves data collection and the analysis of various education-related factors to make decisions that improve educational quality. Systematic is essential for enhancing quality education. This study reports a case student-conducted process medical school’s student support system procedure devising improvement plans. Sixteen Inje University College Medicine students participated in Education Evaluation Committee (IUCM-EEC) understand as learners actively achieve...