A5100619127- CRISPR and Genetic Engineering
- Sirtuins and Resveratrol in Medicine
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Diet and metabolism studies
- SARS-CoV-2 and COVID-19 Research
- Nanoparticle-Based Drug Delivery
- Advanced Battery Materials and Technologies
- Genetics, Aging, and Longevity in Model Organisms
- Advanced Drug Delivery Systems
- Microbial Metabolic Engineering and Bioproduction
- Advancements in Solid Oxide Fuel Cells
- Prion Diseases and Protein Misfolding
- Metabolism and Genetic Disorders
- Fuel Cells and Related Materials
- Fungal and yeast genetics research
- Genetic factors in colorectal cancer
- COVID-19 Clinical Research Studies
- Heat Transfer and Boiling Studies
- Transgenic Plants and Applications
- Advanced battery technologies research
- Clostridium difficile and Clostridium perfringens research
- RNA and protein synthesis mechanisms
- Melanoma and MAPK Pathways
- Protein Kinase Regulation and GTPase Signaling
Seoul National University
2024-2025
Korea Institute of Energy Research
2019-2025
Chung-Ang University
2012-2024
Biomed Research Institute
2023-2024
JINIS Biopharmaceuticals (South Korea)
2014-2023
Kyungpook National University
2022
UCLA Medical Center
2022
University of California, Los Angeles
2022
Korea Advanced Institute of Science and Technology
2009-2021
Harbor–UCLA Medical Center
2020-2021
Abstract In order to address the challenges associated with lithium–sulfur batteries high energy densities, various approaches, including advanced designs of sulfur composites, electrolyte engineering, and functional separators, are lately introduced. However, most approaches effective for cathodes limited contents, i.e., <80 wt%, imposing a significant barrier in realizing densities practical cell settings. Here, elemental sulfur‐mediated synthesis perfluorinated covalent triazine...
The prevailing amyloid hypothesis for Alzheimer's disease (AD) holds that beta-protein (Abeta) causes neuronal degeneration by forming neurotoxic fibrillar structures. Yet, many aspects of AD pathology and symptoms are not well explained this hypothesis. Here, we present evidence neurotoxicity soluble oligomeric Abeta closely corresponds to the selective neurodegeneration so distinctly manifest in AD. Selectivity was first observed vitro, where only human central nervous system cells were...
A variety of advanced electrode structures have been developed lately to address the intrinsic drawbacks lithium–sulfur batteries, such as polysulfide shuttling and low electrical conductivity elemental sulfur. Nevertheless, it is still desired find that those issues through an easy synthesis while securing large sulfur contents (i.e., > 70 wt %). Here, we report orthogonal, "one-pot" synthetic approach prepare a sulfur-embedded polybenzoxazine (S-BOP) with high content 72 %. This polymer...
Despite the high energy densities, lithium–sulfur (Li–S) batteries suffer from insufficient cycle life originating shuttling process involving lithium polysulfides (LiPSs). Various approaches have been introduced to resolve problem, but they are not usually effective for electrodes with sulfur contents. Here, we report an exfoliated 2D lepidocrocite titanium oxide nanosheet as a component cathodes suppress polysulfide dissolution markedly. In particular, Lewis acidity undercoordinated Ti...
The current gut microbiome research relies on the fecal under assumption that represents of entire gastrointestinal (GI) tract. However, there have been growing concerns about using feces as a proxy to study microbiome. Here, we comprehensively analyzed composition and metabolites in at 14 different locations GI tracts genetically homogenous sibling pigs evaluate validity whole intestinal microbes constituting each content their metabolic compositions were thoroughly investigated through...
Resveratrol has been clinically shown to possess a number of human health benefits. As result, many attempts have made engineer resveratrol production in major cereal grains but largely unsuccessful. In this study, we report the creation transgenic rice plant that accumulates 1.9 µg resveratrol/g its grain, surpassing previously reported anti-metabolic syndrome activity through synergistic interaction between and endogenous properties rice. Consumption our resveratrol-enriched significantly...
Despite the potential protective role of gut microbiome against COVID-19, specific microbes conferring resistance to COVID-19 have not yet been identified. In this work, we aimed identify and validate at species level that provide protection SARS-CoV-2 infection. To conducted a fecal microbiota transplantation (FMT) from an individual with no history infection or immunization into lethal hamster model. FMT COVID-19-resistant donor resulted in significant phenotypic changes related...
Recent findings on the association of gut microbiota with various diseases, including obesity, prompted us to investigate possibility using a certain type bacteria as safe therapeutic for obesity. Lactobacillus mutants enhanced capacity in absorption free fatty acids (FFAs) were isolated show reduced FFAs by administered host, attributing inhibition body weight gain and fat accumulation well amelioration blood profiles. Consequently, high throughput screening natural FFAs-absorbing...
Although CRISPR-dCas13, the RNA-guided RNA-binding protein, was recently exploited as a translation-level gene expression modulator, it has still been difficult to precisely control level due lack of detailed characterization. Here, we develop synthetic tunable CRISPR interference (Tl-CRISPRi) system based on engineered guide RNAs that enable precise and predictable down-regulation mRNA translation. First, optimize Tl-CRISPRi for specific multiplexed repression genes at translation level. We...
Three new sesterterpenoids, phorbaketals A (1), B (2), and C (3) which have a spiroketal of the hydrobenzopyran moiety, were isolated from Korean marine sponge Phorbas sp. Their complete structures elucidated by spectral chemical methods. They exhibited moderate cytotoxicity against human colorectal, hepatoma, lung cancer cell lines. Furthermore, cultivation bacterial fraction afforded compound 1.
Abstract Obesity is the most prevalent disease in world which poses a serious risk for various chronic diseases. However, currently there are not any therapeutic agents that reduce body weight without causing side effects. In order to prevent and/or treat obesity and related diseases through nutraceutical approach, we created resveratrol-enriched transgenic rice accumulating 1.4 μg/g of resveratrol its grain, DJ-526. Feeding mice with DJ-526 showed excellent anti-obesity effect reduction...
Protein therapeutics are emerging as essential technologies due to their functional and chemical properties. However, application is currently limited delivery by oral injection methods—the former being inefficient the latter invasive potentially tissue damaging. Researchers are, therefore, exploring noninvasive systems for proteins through skin, including transdermal topical delivery. The large molecular size of presents a key challenge skin penetration, hindering ability penetrate dense...
OPINION article Front. Microbiol., 06 July 2018Sec. Food Microbiology Volume 9 - 2018 | https://doi.org/10.3389/fmicb.2018.01510
One of the main characteristics cancer tissues is poor development neovascularization that results in a limited blood circulation. Because this phenomenon, it harder for to diffuse their elevated heat into other parts body. The scientific principle radiofrequency hyperthermia relies on quality which with higher temperature becomes more apparent. Despite obvious necessity selectively tissue hyperthermia, proper thermosensitizer has not been developed until now. Here, we show transferrin...
Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is currently causing a worldwide threat with its unusually high transmission rates and rapid evolution into diverse strains. Unlike typical viruses, SARS-CoV-2 frequently causes systemic infection by breaking the boundaries of systems. The development animal models recapitulating clinical manifestations COVID-19 utmost importance not only for vaccines antivirals but also understanding pathogenesis. However, there has been developed an...
Transdermal or topical skin delivery of protein therapeutics is currently limited due to the large molecular size proteins and dense structure skin. Although some nanoparticles enhancers have been used increase penetration stability, few studies examined effect combination on penetration. Here, we introduce Polycaprolactone (PCL) Pluronic F-127-based polymeric (PNPs) load different-sized proteins, including insulin (INS), trypsin inhibitor (TI), horseradish peroxidase (HRP), bovine serum...
This study analyzes flow uniformity in U-flow pattern and Z-flow solid oxide fuel cell (SOFC) stacks, assessing their performance under different stack heights rates of fuel/air usage. Both configurations achieved satisfactory distribution the anode region at 1 kWe scale, especially with design demonstrating enhanced stability. However, as height increased, particularly 3 kWe, decreased significantly. In cathode region, was highly sensitive to changes air utilization rate, lower causing more...